Gastric Pyogenic Granuloma Detected due to Abdominal Symptoms and Treated with Endoscopic Resection

Shibata, Tomoyuki; Ichikawa, Yasuo; Okubo, Masaaki; Tahara, Tomomitsu; Ishizuka, Takamitsu; Hirata, Ichiro

doi:10.2169/internalmedicine.52.1133

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…[13][14][15] miR-145 represses mediators of EMT, such as insulinlike growth factor 1 receptor (IGF1R), fascin-1, and paxillin, to suppress cell proliferation and metastasis in colorectal cancer. [16][17][18] Importantly, miR-145 is also an essential component of the p53 regulatory network. 19 p53 is a critical repressor of c-myc mediated through miR-145 induction.…”

Section: Introductionmentioning

confidence: 99%

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer

et al. 2018

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Epithelial-to-mesenchymal transition (EMT) has been closely linked with therapy resistance and cancer stem cells (CSCs). However, EMT pathways have proven challenging to therapeutically target. MicroRNA 145 (miR-145) targets multiple stem cell transcription factors and its expression is inversely correlated with EMT. Therefore, we hypothesized that miR-145 represents a therapeutic target to reverse snail family transcriptional repressor 1 (SNAI1)-mediated stemness and radiation resistance (RT). Stable expression of SNAI1 in DLD1 and HCT116 cells (DLD1-SNAI1; HCT116-SNAI1) increased expression of Nanog and decreased miR-145 expression compared to control cells. Using a miR-145 luciferase reporter assay, we determined that ectopic SNAI1 expression significantly repressed the miR-145 promoter. DLD1-SNAI1 and HCT116-SNAI1 cells demonstrated decreased RT sensitivity and, conversely, miR-145 replacement significantly enhanced RT sensitivity. Of the five parental colon cancer cell lines, SW620 cells demonstrated relatively high endogenous SNAI1 and low miR-145 levels. In the SW620 cells, miR-145 replacement decreased CSC-related transcription factor expression, spheroid formation, and radiation resistance. In rectal cancer patient-derived xenografts, CSC identified by EpCAM+/aldehyde dehydrogenase (ALDH)+ demonstrated high expression of SNAI1, c-Myc, and Nanog compared with non-CSCs (EpCAM+/ALDH-). Conversely, patient-derived CSCs demonstrated low miR-145 expression levels relative to non-CSCs. These results suggest that the SNAI1:miR-145 pathway represents a novel therapeutic target in colorectal cancer to overcome RT resistance.

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Section: Introductionmentioning

confidence: 99%

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer

et al. 2018

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“…Pyogenic granuloma involves the mucosa, extends to the submucosa, and presents as a polypoid, strawberry‐red excrescence 18,20 . On CT, pyogenic granuloma of the stomach displays strong enhancement by contrast medium 19 . Based on our review of the literature, no study has reported on pyogenic granuloma of the stomach in dogs.…”

Section: Discussionmentioning

confidence: 96%

“…18,20 On CT, pyogenic granuloma of the stomach displays strong enhancement by contrast medium. 19 Based on our review of the literature, no study has reported on pyogenic granuloma of the stomach in dogs. In this study, pyogenic granuloma was found to form symmetric thickening lesions that involved both the mucosa and outer layers.…”

Section: Discussionmentioning

confidence: 99%

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Contrast‐enhanced CT features of pyloric lesions in 17 dogs: Case series

Tanaka¹,

Wada

Noguchi³

et al. 2022

Vet Radiology Ultrasound

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Pyloric outflow obstructions can be caused by several types of lesions. When a thickened gastric wall and pyloric mass are detected, malignant neoplasia must be differentiated from chronic hypertrophic pyloric gastropathy. CT can characterize gastric tumors. However, based on the authors’ review of the literature, there is limited information about the CT findings of pyloric lesions. The purpose of this retrospective case series study was to assess the CT findings of canine pyloric lesions. The following CT parameters were recorded: anatomical area, involved area, lesion shape, growth patterns of wall thickening lesions, enhancement pattern of the lesion in the early and delayed phases, lymphomegaly, and pulmonary metastasis. Seventeen dogs were included in this study and had the following final diagnoses: hyperplasia (five dogs), adenoma (five dogs), adenocarcinoma (three dogs), gastrointestinal stromal tumor (GIST; two dogs), polyposis (one dog), and pyogenic granuloma (one dog). Hyperplasia, adenoma, and polyposis formed mass lesions that involved the mucosal layer. Lymphomegaly was detected in two Jack Russell terriers with hyperplasia; however, the causes were unknown because we did not perform biopsies. All adenocarcinomas formed wall‐thickened lesion that involved the outer layer, with lymphomegaly. All GISTs formed mass lesion that involved the outer layer. The pyogenic granulomas formed symmetric wall‐thickened lesion that involved the mucosal and outer layers. CT facilitated the characterization of canine pyloric lesions using contrast enhancement, based on the involved area and lesion shape. However, polyposis may require caution in diagnosis based on CT findings alone.

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“…Other presentations are rarely reported and depend on the anatomical location of the PG. For instance, esophageal lesions can present with dysphagia [ 13 ], stomach lesions as gastritis [ 26 ], small intestine lesions as intussusception [ 25 , 27 ], or rectum lesions as tenesmus [ 28 ]. Four (8%) patients were asymptomatic and their PG lesions were found incidentally.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia

Meeks

Kamal

Hammami

et al. 2016

Case Reports in Gastrointestinal Medicine

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Pyogenic granuloma (PG), more accurately known as lobular capillary hemangioma, is a benign vascular tumor that usually occurs in the skin or oral mucosa. This lesion is rarely reported in the gastrointestinal tract but is known to bleed if not resected. We herein describe a case series with the clinical, endoscopic, and histologic findings of four cases of gastrointestinal PG at our institution. In addition, we provide a review of the literature and summation of all reported cases of PG specific to the gastrointestinal tract. Based on our experience, we suggest that the actual incidence of gastrointestinal PG may in fact be higher than reported because PG can be unrecognized or improperly diagnosed. It is important for the clinician to properly recognize this lesion as a source of anemia and its propensity to bleed during biopsy or resection.

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Gastric Pyogenic Granuloma Detected due to Abdominal Symptoms and Treated with Endoscopic Resection

Cited by 4 publications

References 8 publications

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer

Contrast‐enhanced CT features of pyloric lesions in 17 dogs: Case series

Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia

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