Gastric Plication and Sleeve Gastrectomy in an Experimental Model of Obesity: New Insights into Weight Loss, Intake and Metabolic Results

Cabrera, Andrea Rugerio; Vives, Margarita; López, Alicia Molina; París, Marta; Raga, E; Sánchez, A Prieto; Sabench, Fàtima; Déjardin, Daniel del Castillo

doi:10.1007/s11695-018-3340-7

Cited by 2 publications

(3 citation statements)

References 43 publications

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“…Clinical and experimental studies showed improvements in the control of blood glucose levels after bariatric surgery, 37,53 and/or after gastric plication. 54,55 Our findings also revealed higher lipid levels in obese animals compared to control groups, while HDL-c levels were lower. Shortterm 30 days after surgery were not enough to ameliorate the lipid profile, probably due to insulin resistance and proinflammatory adipokines.…”

Section: Histopathologysupporting

confidence: 65%

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Gastric plication surgery changes gastrointestinal and metabolic parameters in an obesity‐induced high‐fat diet model

Machado,

Gama,

Beckmann

et al. 2023

Neurogastroenterology Motil

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BackgroundObesity treatment includes less invasive procedures such as gastric plication (GP) surgery; however, its effects on gastrointestinal (GI) motility parameters are underestimated. We aimed to verify the metabolic and gastrointestinal effects of GP surgery in the rat obesity model.MethodsA high‐fat diet‐induced obesity was used. Animals were allocated to four experimental groups: control sham (n = 6); control GP (n = 10); obese sham (n = 6); and obese GP (n = 10). Nutritional and murinometric parameters, gastric motility, glucose tolerance, histopathology, fat depots, leptin, and lipoproteins levels were evaluated 30 days after surgery. Data were analyzed by ANOVA followed by post Tukey or Kruskal–Wallis test followed by Dunn's multiple comparisons test.Key ResultsGastric plication decreased leptin levels, feed efficiency, and body weight gain. GP does not improve lipid profile in obese animals and however, ameliorates glucose tolerance in control and obese rats. GP did not improve the gastric emptying time or normalize the frequency of contractions disturbed by obesity. Surgery provides a remodeling process in the mucosa and muscularis mucosa layers, evidenced by leukocyte infiltration mainly in the mucosa layer.Conclusions & InferencesOur study revealed the influence of the gastrointestinal tract on obesity is underestimated with pieces of evidence pointing out its important role as a target for surgical treatment.

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Section: Histopathologysupporting

confidence: 65%

“…Besides, both hyperglycemia and slow GE lead to satiety combined with high feed efficiency. Clinical and experimental studies showed improvements in the control of blood glucose levels after bariatric surgery, 37,53 and/or after gastric plication 54,55 …”

Section: Discussionmentioning

confidence: 99%

Gastric plication surgery changes gastrointestinal and metabolic parameters in an obesity‐induced high‐fat diet model

Machado,

Gama,

Beckmann

et al. 2023

Neurogastroenterology Motil

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show abstract

“…; Roux-en-Y Gastric bypass surgery). 12 Postoperative Vomiting is often triggered by different things, such as anxiety, illness, perioperative stimuli, anesthesia, drug interactions, marginal ulceration, staple line failure, stenosis/obstruction, gastrogastric fistula, gastrojejunostomy anastomotic stricture, pouch dilation, and pouch gastritis. 13 In our study 100 patients who underwent LBS were included in this retrospective clinical trial over a 6 months period to evaluate the percentage of Postoperative Vomiting occurrence after surgery for two months of follow up.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Vomiting as a Complication for Laparoscopic Bariatric Surgeries: A Retrospective Study

Marzouk

Ibrahim

Afifi

et al. 2019

Ain Shams Journal of Surgery

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Introduction:Vomiting is a postoperative complication in all bariatric surgical interventions since the focus of the procedure is related to the stomach, research efforts are required to reveal the best management course for this issue. Aim of the work:The primary study objective is to assess the percentage of postoperative vomiting occurrence after laparoscopic bariatric surgeries for two months, its causes with investigations and ways of management. Patients and methods:The current research study is a retrospective clinical research trial that recruited 100 cases. All study subjects have undergone Laparoscopic Bariatric Surgeries over a 6 months period in Ain Shams University Hospitals during the period from December 2017 to June 2018.Results: A large percentage of patients (39%) developed Postoperative Vomiting during the first 48 postoperative hours. While (4%) of cases who continued to suffer from Vomiting during the postoperative 2 months. Conclusions:Postoperative vomiting after Laparoscopic Bariatric Surgeries (LBS) represents a considerable complication which occurs commonly. Vomiting of medical causes responds well to centrally acting antiemetic and to a lesser extent, endoscopic and surgical interventions were required for technical problems.

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Gastric Plication and Sleeve Gastrectomy in an Experimental Model of Obesity: New Insights into Weight Loss, Intake and Metabolic Results

Cited by 2 publications

References 43 publications

Gastric plication surgery changes gastrointestinal and metabolic parameters in an obesity‐induced high‐fat diet model

Gastric plication surgery changes gastrointestinal and metabolic parameters in an obesity‐induced high‐fat diet model

Postoperative Vomiting as a Complication for Laparoscopic Bariatric Surgeries: A Retrospective Study

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