Gastric peroral endoscopic myotomy for refractory gastroparesis: first human endoscopic pyloromyotomy (with video)

Early human experience with per-oral endoscopic pyloromyotomy (POP)

“…Subsequently, the first clinical experience of submucosal endoscopic esophageal myotomy was reported in Japan for patients with achalasia [13,14]. Since that time, the procedure has been performed worldwide resulting in a rapidly increasing body of literature documenting the safety and efficacy of the technique [15][16][17][18]. It is hypothesized that this technique can be adapted to perform complete endoluminal dissection of the pylorus via a submucosal tunnel for patients with gastric emptying disorders.…”

Endoscopic pyloromyotomy for postesophagectomy gastric outlet obstruction

“…Recently, endoscopic pyloromyotomy, also called gastric peroral endoscopic myotomy (POEM), has been reported, in pigs and in a patient with refractory diabetic gastroparesis [2,3]. We report a case of postesophagectomy delayed gastric emptying that was successfully treated with endoscopic pyloromyotomy.…”

Peroral endoscopic pyloromyotomy for primary pyloric stenosis

“…The standard treatment is balloon dilation, pyloroplasty, or occasionally surgical distal gastrectomy [1]. Peroral endoscopic pyloromyotomy (POP) has been used to improve gastric emptying in selected patients with refractory gastroparesis due to diabetes [2,3] or with gastric outlet obstruction following esophagectomy [4]. To the best of our knowledge, this is the first case in which POP was used to treat PPS.…”