A 2-year-old, male German Shepherd dog with a history of chronic diarrhea was presented for restlessness and vomiting 4 hours after chewing a plastic container with methylene-diphenyl-diisocyanate (MDI)-based glue. Clinical examination revealed dehydration, fever and a large painful rigid mass in the cranial abdomen. Abdominal radiography showed a radiopaque, round, cranial abdominal mass, along with air-filled loops proximally and distally. Except for leukocytosis, high blood haematocrit and increased total proteins, blood and serum analysis tests were normal. After initial stabilization, the foreign body was removed, along with part of the jejunum, through enterectomy and enteroanastomosis. On macroscopic evaluation, the foreign body was embedded in the intestinal mucosa. The dog recovered uneventfully. To the authors' knowledge, this is the first reported case of intestinal obstruction after MDI-based glue ingestion in a dog.