Gastric mucosal blood flow measured by laser-Doppler velocimetry

Kiel, Jeffrey W.; Riedel, G. L.; DiResta, Gene R.; Shepherd, A. P.

doi:10.1152/ajpgi.1985.249.4.g539

Cited by 39 publications

(17 citation statements)

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“…Accordingly, LDF has proven useful for measurement of blood flow changes in the cerebral cortex (6,24), gastrointestinal canal (12,18,21,23),myocardial and skeletal muscle (1,10,14),skin (3,11,26), and renal cortex (22). So far, only a few Received December 30,1991; accepted January 18,1993.…”

Section: Discussionmentioning

confidence: 99%

Laser doppler flowmetry for estimation of bone blood flow: Studies of reproducibility and correlation with microsphere technique

Lausten

Kiaer

Dahl

1993

Journal Orthopaedic Research

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The blood flow in the femoral condyles of six pigs was measured by the microsphere technique and by laser Doppler flowmetry (LDF) before and after clamping of the external iliac artery. A significant decrease in the bone blood flow was found with both microsphere and LDF measurements, and a high correlation was found between the two methods. After release of the arterial clamp, the LDF values rapidly returned to approximately the same values as before clamping. In a second part of the study, the LDF output signal was studied in the intertrochanteric area of eight patients. The reproducibility of two LDF measurements at the same location was within 15%. The temporal variability of the LDF signal during 10 min of recording showed only slight variations. It is concluded that LDF is relative in nature and that the mean LDF output signal is suitable for monitoring dynamic responses of the bone blood flow to various stimuli. Several consecutive measurements have to be performed if the blood flow at different locations of a specific bone are to be compared with each other.

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Section: Discussionmentioning

confidence: 99%

Laser doppler flowmetry for estimation of bone blood flow: Studies of reproducibility and correlation with microsphere technique

Lausten

Kiaer

Dahl

1993

Journal Orthopaedic Research

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“…The laser Doppler technique has been widely used to estimate gastrointestinal mucosal perfusion [7, 19, 20, 21, 22]. After the patient fasted overnight, we performed a routine endoscopic examination and measured the gastric mucosal blood flow (GMBF) by passing the endoscopic probe (PF-309; Perimed, Stockholm, Sweden) of the laser Doppler flowmeter (Periflux PF-3; Perimed) through the biopsy channel of the fiberscope.…”

Section: Methodsmentioning

confidence: 99%

Role of Vascular Endothelial Growth Factor in Portal Hypertensive Gastropathy

Tsugawa¹,

Hashizume

Migou³

et al. 2000

Digestion

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Background and Aims: Portal hypertensive gastropathy (PHG) is now recognized as a distinct entity; however, the angiogenesis in the portal hypertensive gastric mucosa has yet to be elucidated. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved in both physiological and pathological angiogenesis. The aim of this study was thus to examine the function of VEGF in the portal hypertensive and non-portal hypertensive gastric mucosa. Method: Forty-five cirrhotic patients were divided into 3 groups as follows. Group I included 15 patients without PHG who were treated with 1.5 g teprenone/day for 8 weeks: PHG(–)-t. Group II included 15 patients with PHG who were not treated with teprenone: PHG(+)-n. Group III included 15 patients with PHG who were treated with teprenone for 8 weeks: PGH(+)-t. The gastric mucosal blood flow (GMBF), the concentration of gastric mucosal VEGF and hexosamine and the endoscopic findings were studied both before and after medication. Results: Before teprenone treatment, the GMBF in the antrum, fundus, fornix were significantly higher in PHG(+)-n than PHG(–)-t. After treatment, the GMBF in the fundus and fornix significantly decreased more than before treatment in the PHG(+)-t. After treatment, the GMBF in the antrum increased significantly more than before treatment in PHG(–)-t. The gastric VEGF and hexoxamine concentration in the antrum were significantly higher in PHG(+)-n than in PHG(–)-t. After treatment, the gastric VEGF and hexosamine concentration in the antrum significantly decreased in PHG(+)-t while no change in concentration was recognized in PHG(+)-n. In the endoscopic findings, a decrease in the PHG score was recognized in 2 patients in PHG(+)-t. Conclusion: Portal hypertensive gastric mucosal change was thus found to trigger a high concentration of VEGF and hexosamine. Such increased activity of VEGF and hexosamine may thus account for the presence of active congestion in PHG.

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“…In view of conflicting re sults with previous techniques in assessing gastric hemodynamics, newer methods have been used to measure gastric mucosal blood flow in patients with PHG. Laser Doppler flowmetry and reflectance spectrophotometry are two approaches recently validated as reli able techniques to assess gastrointestinal mu cosal perfusion [72,73], Using both methods some investigators have confirmed the pres ence of increased gastric mucosal perfusion in PHG, being greater in patients with severe PHG [12,13]. Contrary to these findings, Iawo et al [74] and Kotzampassi et al [75] reported a reduced gastric mucosal blood flow in patients with PHG.…”

Section: Gastric Mucosai Hemodynamics and Microcirculationmentioning

confidence: 99%

Portal Hypertensive Gastropathy

Trevino

Brady²,

Schenker

1996

Dig Dis

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Portal hypertensive gastropathy (PHG) is part of a complex syndrome which occurs as a complication of chronic liver disease and portal hypertension (PHTN). At endoscopy, the gastric mucosa shows that mosaic-like pattern and red marks, which are the source of gastric bleeding. Only the severe form of gastropathy is liable to bleed. The pathogenesis of PHG and the hemodynamic changes in PHTN are not completely understood, but chronic increase in portal pressure is a prerequisite for the development of this disorder. It has been suggested that an overproduction of endogenous vasodilators and a reduced vascular sensitivity to endogenous vasoconstrictors contribute to these circulatory disturbances. H₂ receptor antagonists and sucralfate are ineffective in the management of bleeding PHG. Two small studies reported that propranolol is effective in arresting mucosal hemorrhage from severe PHG. Other feasible alternatives include transjugular intrahepatic portal-systemic shunt (TIPS) and portal-systemic shunt procedure.

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Gastric mucosal blood flow measured by laser-Doppler velocimetry

Cited by 39 publications

References 0 publications

Laser doppler flowmetry for estimation of bone blood flow: Studies of reproducibility and correlation with microsphere technique

Laser doppler flowmetry for estimation of bone blood flow: Studies of reproducibility and correlation with microsphere technique

Role of Vascular Endothelial Growth Factor in Portal Hypertensive Gastropathy

Portal Hypertensive Gastropathy

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