Gastric Microbiota Gender Differences in Subjects with Healthy Stomachs and Autoimmune Atrophic Gastritis

Pivetta, Giulia; Dottori, Ludovica; Fontana, Federico; Cingolani, Sophia; Ligato, Irene; Dilaghi, Emanuele; Milani, Christian; Ventura, Marco; Borro, Marina; Esposito, Gianluca; Annibale, Bruno; Lahner, Edith

doi:10.3390/microorganisms11081938

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Women with healthy stomachs had reduced biodiversity but a two-fold higher gastric bacterial abundance compared to men. On the contrary, the bacterial abundance of AAG patients was not characterized by significant gender differences, possibly because of hypochlorhydria that halved the bacterial abundance in women and had a minimum impact on it in men [91].…”

Section: Aag and Hypochlorhydria: What Are The Consequences On The Ga...mentioning

confidence: 89%

“…The composition of the gastric microbiota depends on many different factors. Pivetta et al [91] observed that there were differences between men's and women's gastric microbiota in both healthy stomachs and stomachs affected by AAG. Particularly, in healthy people, there was a lower biodiversity in females compared to that of males; instead, in patients affected by AAG, there was a significantly lower biodiversity in the males than in the females.…”

Section: Aag and Hypochlorhydria: What Are The Consequences On The Ga...mentioning

confidence: 99%

See 1 more Smart Citation

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Vavallo,

Cingolani,

Cozza

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

Autoimmune atrophic gastritis is an immune-mediated disease resulting in autoimmune destruction of the specialized acid-producing gastric parietal cells. As a consequence, in autoimmune atrophic gastritis, gastric acid secretion is irreversibly impaired, and the resulting hypochlorhydria leads to the main clinical manifestations and is linked, directly or indirectly, to the long-term neoplastic complications of this disease. In the last few years, autoimmune atrophic gastritis has gained growing interest leading to the acquisition of new knowledge on different aspects of this disorder. Although reliable serological biomarkers are available and gastrointestinal endoscopy techniques have substantially evolved, the diagnosis of autoimmune atrophic gastritis is still affected by a considerable delay and relies on histopathological assessment of gastric biopsies. One of the reasons for the diagnostic delay is that the clinical presentations of autoimmune atrophic gastritis giving rise to clinical suspicion are very different, ranging from hematological to neurological–psychiatric up to gastrointestinal and less commonly to gynecological–obstetric symptoms or signs. Therefore, patients with autoimmune atrophic gastritis often seek advice from physicians of other medical specialties than gastroenterologists, thus underlining the need for increased awareness of this disease in a broad medical and scientific community.

show abstract

Section: Aag and Hypochlorhydria: What Are The Consequences On The Ga...mentioning

confidence: 89%

Section: Aag and Hypochlorhydria: What Are The Consequences On The Ga...mentioning

confidence: 99%

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Vavallo,

Cingolani,

Cozza

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Gender Differences in Quality of Bowel Preparation for Colonoscopy

Maida,

Vitello,

Zullo

et al. 2024

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

Objective: Bowel cleansing is a key element for a quality colonoscopy. Despite recent advances, not all predictors of successful cleansing are fully known. This post hoc analysis of an RCT aims to explore gender differences in bowel cleansing quality. Methods: The “OVER” trial was a multicenter phase-4 RCT including 478 patients randomized 1:1 to receive split-dose 1L polyethylene glycol plus ascorbate (PEG+ASC) or 4L-PEG. In this post hoc analysis, multivariable logistic regression models were designed to assess predictors of cleansing success (CS) and adenoma detection rate (ADR) by gender. Results: Of the 478 randomized patients, 50.2% were males and 49.8% females. Overall, CS was comparable between females and males (87.1% vs 88.4, P = 0.6), whereas CS in the right (95.7% vs 90.9, P = 0.049) and transverse colon (98.6% vs 93.9, P=0.011) was significantly higher in females. At multivariable regression analysis for CS outpatient setting (OR = 5.558) and higher withdrawal time (OR = 1.294) were independently associated with CS in females, whereas screening/surveillance indication (OR = 6.776) was independently associated with CS in males. At multivariable regression analysis for ADR, running time <5 hours (OR = 3.014) and higher withdrawal time (OR = 1.250) were independently associated with ADR in females, whereas older age (OR = 1.040) and higher withdrawal time (OR = 1.093) were independently associated with ADR in males. Conclusions: This study showed different results in bowel preparation quality and different predictors of CS and ADR by gender. These findings suggest the need for further research to explore gender-specific approaches for bowel preparation.

show abstract

Autoimmune gastritis studies and gastric cancer: True renaissance or bibliometric illusion

Isakov

2024

World J Gastroenterol

View full text Add to dashboard Cite

A bibliometric analysis of studies dedicated to autoimmune gastritis (AIG) recently published demonstrated a noteworthy surge in publications over the last three years. This can be explained by numerous publications from different regions of the world reporting the results of several studies that stimulated reassessment of our view of AIG as a precancerous condition. Follow-up studies and retrospective analyses showed that the risk of gastric cancer (GC) in AIG patients is much lower than expected if the patients ever being infected with Helicobacter pylori (H. pylori ) were excluded. The low prevalence of precancerous lesions, such as the incomplete type of intestinal metaplasia, may explain the low risk of GC in AIG patients because the spasmolytic polypeptide-expressing metaplasia commonly observed in AIG does not involve clonal reprogramming of the gastric gland and can be considered as an adaptive change rather than a true precancerous lesion. However, changes in gastric secretion due to the progression of gastric atrophy during the course of AIG cause changes in the gastric mic-robiome, stimulating the growth of bacterial species such as streptococci, which may promote the development of precancerous lesions and GC. Thus, Streptococcus anginosus exhibited a robust proinflammatory response and induced the gastritis-atrophy-metaplasia-dysplasia sequence in mice, reproducing the well-established process for carcinogenesis associated with H. pylori . Prospective studies in H. pylori -naïve patients evaluating gastric microbiome changes during the long-term course of AIG might provide an explanation for the enigmatic increase in GC incidence in the last decades in younger cohorts, which has been reported in economically developed countries.

show abstract

Gastric Microbiota Gender Differences in Subjects with Healthy Stomachs and Autoimmune Atrophic Gastritis

Cited by 3 publications

References 29 publications

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Gender Differences in Quality of Bowel Preparation for Colonoscopy

Autoimmune gastritis studies and gastric cancer: True renaissance or bibliometric illusion

Contact Info

Product

Resources

About