Gastric Metastasis of Lung Cancer Mimicking an Adrenal Tumor

Hung, Tsung I; Chu, Kuang-En; Chou, Yenn Hwei; Yang, Kuo-Ching

doi:10.1159/000360845

Cited by 5 publications

(3 citation statements)

References 5 publications

(7 reference statements)

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“…Squamous cell carcinoma (28.5%), adenocarcinoma (27.6%) and large cell carcinoma (20.9%) are the three most common histological types of NSCLC to develop distant metastasis (5). Small intestinal metastasis from NSCLC is unusual (11)(12)(13)(14). Recently, the incidence of GI metastasis from lung cancer has been reported to be <2% (14).…”

Section: Discussionmentioning

confidence: 99%

Lung carcinoma with small intestinal metastases and gastrointestinal bleeding: A rare case report

et al. 2023

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The occurrence of small intestinal metastases from primary lung cancer is rare. This report documents the case of a 57-year-old male patient initially diagnosed with non-metastatic lung adenocarcinoma, who presented with abdominal pain 6 months later. Postoperative pathological analysis confirmed the final diagnosis to be small intestinal metastasis from primary lung cancer. Thoracoscopic surgery and systemic chemotherapy were the preferred treatment options. However, the lung tumor spread to the small intestine, causing intestinal obstruction. As the patient could not tolerate anti-tumor therapy, only symptomatic treatment was provided. The patient experienced massive gastrointestinal bleeding and died the next day. Although small intestinal metastasis from lung cancer is rare and difficult to diagnose accurately, it should be considered when encountering a patient with lung cancer exhibiting abdominal symptoms and associated imaging findings. At this point, a pathological diagnosis should be performed immediately to determine the nature and source of the tumor. Furthermore, individualized treatment should be conducted in strict accordance with oncology guidelines. Of note, early detection and treatment are critical to ensure favorable outcomes.

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Section: Discussionmentioning

confidence: 99%

Lung carcinoma with small intestinal metastases and gastrointestinal bleeding: A rare case report

et al. 2023

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“… 3 The most frequent sites for distant metastasis of lung cancer are the liver, adrenal glands, bones, and brain. 4 In contrast, metastasis of lung cancer to the GI tract is a relatively rare event in the clinical setting. Rates of metastasis to the esophagus and the stomach are low, with reported incidences of 6.4% to 7.8% and 0.2% to 1.7%, respectively, based on clinical and autopsy findings.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Esophageal and Gastric Metastases from Lung Cancer

et al. 2015

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We report of a patient with metastatic adenocarcinoma of the esophagus and stomach from lung cancer. The patient was a 68-year-old man receiving radiotherapy and chemotherapy for stage IV lung cancer, without metastases to the gastrointestinal (GI) tract at the time of the initial diagnosis. During the treatment period, dysphagia and melena newly developed. Upper GI endoscopy revealed geographic erosion at the distal esophagus and multiple volcano-shaped ulcers on the stomach body. Endoscopic biopsy was performed for each lesion. To determine whether the lesions were primary esophageal and gastric cancer masses or metastases from the lung cancer, histopathological testing including immunohistochemical staining was performed, and metastasis from lung cancer was confirmed. The disease progressed despite chemotherapy, and the patient died 5 months after the diagnosis of lung cancer. This is a case report of metastatic adenocarcinoma in the esophagus and stomach, which are very rare sites of spread for lung cancer.

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“…81 Regarding the treatment of gastric metastases of the pulmonary origin, although non-invasive chemotherapy treatments were the most common choice, patients who received surgery, particularly partial gastrectomy, but also esophagogastrostomy and laparotomy, tended to have relatively much longer survival time. 77,90,95 However, this conclusion is not definitive, since in some cases surgeries may be avoided when the patient's condition is extremely severe and the number of cases with given surgical treatments is scarce. So the potential benefit of surgeries to the expected lifespan of the patients needs further investigation.…”

Section: Lung Cancermentioning

confidence: 99%

Metastasis to the stomach: a systematic review

Ibrahimli,

Aliyev,

Majidli

et al. 2023

F1000Res

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Background: This study reviews the literature on gastric metastases (GM) in terms of diagnosis, treatment, and outcomes. The goal of this study was to provide clinicians with a reliable and beneficial source to understand gastric metastases arising from various primary tumors and to present the growing literature in an easily accessible form. Methods: Articles published in English language from implementation of MEDLINE and Cochrane databases until May 2022 were considered for the systematic review. Articles other than English language, letters to the editor, posters, and clinical images were excluded. Hematogenous and lymphogenic metastases were included whereas direct tumoral invasion and seeding were excluded. Articles and abstracts were analyzed and last selection was done after cross-referencing and by use of defined eligibility criteria. Results: In total 1,521 publications were identified and 170 articles were finally included totaling 186 patients with GM. The median age of patients was 62 years. Gynecologic cancer was the most common cancer type causing GM (67 patients), followed by lung cancer (33 patients), renal cancer (20 patients), and melanoma (19 patients). One of the main treatment methods performed for metastasis was resection surgery (n=62), sometimes combined with chemotherapy (ChT) or immunotherapy. ChT was the other most used treatment method (n=78). Also, immunotherapy was amongst the most preferred treatment options after surgery and ChT (n=10). Conclusions: As 172 case reports were screened in the systematic review from different journals, heterogeneity was inevitable. Some articles missed important information such as complete follow-up or clinical information. Moreover, since all of the included articles were case reports quality assessment could not be performed. Among 172 case reports reviewed, resection surgery was performed the most and was sometimes combined with ChT and immunotherapy. Further research about what type of treatment has the best outcomes for patients with gastric metastases is needed.

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Gastric Metastasis of Lung Cancer Mimicking an Adrenal Tumor

Cited by 5 publications

References 5 publications

Lung carcinoma with small intestinal metastases and gastrointestinal bleeding: A rare case report

Lung carcinoma with small intestinal metastases and gastrointestinal bleeding: A rare case report

Simultaneous Esophageal and Gastric Metastases from Lung Cancer

Metastasis to the stomach: a systematic review

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