Gastric Lipase: Localization in the Human Stomach

Abrams, Cynthia K.; Hamosh, Margit; Lee, Thomas C.; Ansher, Alan F.; Collen, Martin J.; Lewis, James H.; Benjamin, Stanley B.; Hamosh, Paul

doi:10.1016/s0016-5085(88)80063-5

Cited by 86 publications

(43 citation statements)

References 25 publications

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“…Whereas (a) may be due to the large variability in the exocrine reserve capacity of the pancreas, (b) may be due to the action of nonpancreatic lipases. Nonpancreatic lipases may stem from the lingual serous glands and the gastric mucosa, where lipase activi- ty is higher in the upper greater curvature than in the upper lesser curvature and lowest in the antral area of both curvatures [6]. Accordingly, patients with exocrine pancreatic insufficiency may absorb more than 50% of dietary fat despite the absence of measurable pancreatic lipase activity.…”

Section: Definition Of Exocrine Pancreatic Insufficiencymentioning

confidence: 99%

Appropriate pancreatic function tests and indication for pancreatic enzyme therapy following surgical procedures on the pancreas

Lankisch

2001

Pancreatology

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Section: Definition Of Exocrine Pancreatic Insufficiencymentioning

confidence: 99%

Appropriate pancreatic function tests and indication for pancreatic enzyme therapy following surgical procedures on the pancreas

Lankisch

2001

Pancreatology

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“…Dietary triglycerides are not absorbed per se but must be hydrolyzed to free fatty acids and monoglyceride by gastric lipase and pancreatic lipase before uptake. At least three proteins, gastric lipase, pancreatic lipase, and colipase, are involved in the triglyceride absorption process from the small intestine to the enterocytes through to the brush border [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Supplementation of <i>Areca catechu</i> L. Extract Alters Triglyceride Absorption and Cholesterol Metabolism in Rats

Byun¹,

Kim²,

Jeon³

et al. 2001

Ann Nutr Metab

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Areca extracts have already been found to exhibit a strong inhibitory activity on cholesterol absorption in high-cholesterol-fed rats. Accordingly, this study was performed to determine whether Areca extracts also exert an inhibitory activity on triglyceride absorption in triglyceride-fed rats. Male rats were fed a diet containing corn oil (10%, w/w) with or without an Areca nut extract supplement (0.5%, w/w). The supplementation of the Areca extract significantly lowered the absorption of triglyceride and the plasma lipid concentration. The absorbed triglyceride that appeared in the blood after an oral dose of [9,10(n)-³H] triglyceride was significantly lower in the rats supplemented with the Areca nut extract, compared with the control group. The supplementation also significantly lowered the small intestinal pCEase (pancreatic cholesterol esterase) activity by 22.5% compared to the control group. The hepatic and intestinal ACAT (acyl-CoA:cholesterol acyltransferase) activities were significantly decreased in the Areca group compared with the control group. Hence, further studies are needed to elucidate the structure and chemical properties of the active compound in the water-soluble Areca extract that lowers cholesterol absorption.

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“…Dans ces conditions, l'activité de la lipase gastrique s'élève, ce qui atténue quelque peu la maldigestion des lipides. En revanche, d'autres travaux de notre équipe ont certes souligné les anomalies de la sécrétion biliaire et les dérangements de transport des lipides dans la muqueuse [11], mais de plus que la déficience en AG d'absorption intestinale des lipides tout en intégrant dans un corpus de concepts la masse des connaissances nouvellement acquises. En rassemblant les acquis les plus importants des dernières années auxquels notre équipe a d'ailleurs contribué, nous souhaitons illustrer la place que mérite l'intestin grêle, soit celle d'un organe exerçant des fonctions régulatrices et complexes pour moduler l'absorption et le métabolisme des lipides du régime alimentaire.…”

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