Gastric lesions in generalized neurofibromatosis

Hoare, A M; Elkington, S. G.

doi:10.1002/bjs.1800630610

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…Including our current study, a total of 15 NF‐1 patients with non‐neuromatous non‐adenomatous GI polyps have been reported in the English‐language literature since 1949 . The clinicopathological features of these cases, including our cases, are summarised in Table .…”

Section: Resultsmentioning

confidence: 97%

“…Including our current study, a total of 15 NF-1 patients with non-neuromatous non-adenomatous GI polyps have been reported in the English-language literature since 1949. 7,[9][10][11][12][13][14][15][16][17] The clinicopathological features of these cases, including our cases, are summarised in Table 2. All patients presented with GI symptoms and/or chronic iron deficiency anaemia in cases with a detailed clinical history.…”

Section: I T E R a T U R E R E V I E Wmentioning

confidence: 99%

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Juvenile‐like (inflammatory/hyperplastic) mucosal polyps of the gastrointestinal tract in neurofibromatosis type 1

et al. 2014

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NF-1-associated inflammatory polyps probably represent specific GI manifestations of this disorder, and should be considered, particularly in patients with GI symptoms. They should be distinguished from inflammatory fibroid polyps and from juvenile-like changes associated with ganglioneuroma/ganglioneuromatosis and neurofibroma/neurofibromatosis. Their aetiology remains obscure, but different mechanisms, including NF-1 inactivation, NF-1-associated vasculopathy, and localised mucosal prolapse/damage caused by motility disorders, might be involved.

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Section: Resultsmentioning

confidence: 97%

Section: I T E R a T U R E R E V I E Wmentioning

confidence: 99%

Juvenile‐like (inflammatory/hyperplastic) mucosal polyps of the gastrointestinal tract in neurofibromatosis type 1

et al. 2014

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“…Neural tumors constitute about 5%-10% of benign gastric tumors (32). The majority are nerve sheath tumors (neurinomas, schwannomas, or neuromas).…”

Section: Neural Tumorsmentioning

confidence: 99%

Dedicated Multidetector CT of the Stomach: Spectrum of Diseases

Ba‐Ssalamah¹,

Prokop²,

Uffmann³

et al. 2003

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Multidetector computed tomography (CT) offers new opportunities in imaging of the gastrointestinal tract. When thin collimation is used, near-isotropic imaging of the stomach is possible, allowing high-quality multiplanar reformation and three-dimensional reconstruction of gastric images. Proper distention of the stomach and optimally timed administration of intravenous contrast material are required to detect and characterize disease. In contrast to gastroscopy and double-contrast studies of the stomach, CT provides information about both the gastric wall and the extragastric extent of disease. Preoperative staging of gastric carcinoma appears to be the main clinical indication for multidetector CT. In addition, multidetector CT allows detection of other gastric malignancies (lymphoma, carcinoid tumors, metastases, gastrointestinal stromal tumors) and benign gastric tumors (neural tumors, polyps). Gastric inflammation (gastritis, ulcers, Ménétrier disease) and miscellaneous gastric conditions (emphysema, gastric outlet obstruction, varices) can also be visualized with multidetector CT. Multidetector CT is a valuable tool for the evaluation of gastric wall disease and serves as an adjunct to endoscopy.

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“…Gastric/GEJ lesions are extremely rare with only seven cases reported in the literature for both pediatric and adult populations [ 11 – 14 ]. More specifically, only six cases of gastric/GEJ polyps were reported in NF-I patients including three pediatric NF-1 patients with all polyps locating at the GEJ and three adult NF-I patients with all polyps in the stomach [ 11 , 12 ]. No GEJ juvenile-like polyps have been previously described in adult NF-I patients.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Juvenile-Like Polyp with Neurofibroma at the Gastroesophageal Junction in an Adult with Neurofibromatosis Type I

Aijaz

Draganov

Iqbal

et al. 2017

Case Reports in Pathology

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A 23-year-old Caucasian male with Neurofibromatosis Type I (NF-I) was found to have a submucosal nodule at the gastroesophageal junction (GEJ) and underwent endoscopic submucosal dissection. Histological examination revealed two different lesions within the nodule. The dominant lesion was inflammatory/hyperplastic (juvenile-like) polyp with obliterative vasculopathy while the smaller lesion was a neurofibroma. Gastric/GEJ lesions in NF-I are very rare with only seven cases reported in the literature. Three cases of juvenile-like gastric polyps (located in the antrum, greater curvature, and fundus) have been reported in adult NF-I patients. An inflammatory polyp associated with a neurofibroma has only been described once in the pediatric literature but never in an adult. Our case is unique from those previously described in the literature due to the age of the patient, the presence of 2 histologically separate lesions in one endoscopically evident lesion, and the presence of obliterative vasculopathy in the juvenile-like polyp.

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Gastric lesions in generalized neurofibromatosis

Cited by 11 publications

References 16 publications

Juvenile‐like (inflammatory/hyperplastic) mucosal polyps of the gastrointestinal tract in neurofibromatosis type 1

Juvenile‐like (inflammatory/hyperplastic) mucosal polyps of the gastrointestinal tract in neurofibromatosis type 1

Dedicated Multidetector CT of the Stomach: Spectrum of Diseases

Coexistence of Juvenile-Like Polyp with Neurofibroma at the Gastroesophageal Junction in an Adult with Neurofibromatosis Type I

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