Gastric juice piR‐1245: A promising prognostic biomarker for gastric cancer

Zhou, Xiaorong; Liu, Jianhong; Meng, Anming; Zhang, Lihong; Wang, Min; Fan, Hong; Peng, Wei; Lu, Jianwei

doi:10.1002/jcla.23131

Cited by 25 publications

(28 citation statements)

References 31 publications

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“…Such a meager outcome is conditioned by knowledge of its carcinogenesis which, differently from other digestive tumors such as colorectal cancer, is far from being exhaustive and affects the identification of reliable diagnostic and prognostic biomarkers as well as the discovery of more efficient cures [30-32]. In this regard, recently numerous studies on cytologic and molecular analyses of the intragastric environment have provided interesting results [10-25, 33-35]. On the one hand, compared to the GL0 counterpart, the presence of cancer cells exfoliated into the gastric lumen (GL1) has been associated with an aggressive GC phenotype and credited as an independent prognostic factor of bad prognosis of affected patients [17-19].…”

Section: Discussionmentioning

confidence: 99%

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Combined Analysis of Intragastric Malignant Exfoliation and Ca 72.4 Concentration in Stomach Adenocarcinoma: The “GL1 Ca 72.4” Parameter

et al. 2020

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Introduction/Objective: Differently from other digestive malignancies, gastric cancer (GC) pathobiology is still little known and understood. Recently, cytopathology and molecular biology on gastric juice/gastric lavage (GJ/GL) of GC patients have provided novel and interesting results in terms of screening, diagnosis, prognosis, and therapy. However, entertaining cytologic examination and molecular test as a unified solo-run test is previously unreported. Our aim was to assess the new parameter “GL Ca 72.4” for GC patients. Methods: Between April 2012 and July 2013, GJ/GL obtained from 37 surgical GC patients were tested for the presence/absence (GL1/GL0) of exfoliated malignant cells along with the intragastric concentration of Ca 72.4 (normal value <6.49 ng/mL: Ca 72.4n; elevated level ≥6.49 ng/mL: Ca 72.4+). Results: At a median follow-up of 79.3 months, all the GC alive patients were “GL0 Ca 72.4n.” The “GL1 Ca 72.4+” parameter, in comparison with GL0 Ca 72.4n, strongly correlated with deeper tumor invasion (p = 0.027), severe nodal metastasis (p = 0.012), worst metastatic node ratio (p = 0.041), higher number of metastatic lymph nodes (30 vs. 20 nodes, p = 0.014), angiolymphatic invasion (p = 0.044), advanced stage (p = 0.034), and adjuvant therapy (p = 0.044). The Kaplan-Meier model showed that GL1 Ca 72.4+ subjects had shorter overall survival (OS) than GL0 Ca 72.4n cases (9.7 vs. 43.2 months, respectively, p = 0.042). At univariate analysis, the GL1 Ca 72.4+ parameter resulted a significant prognostic factor for OS (p = 0.023). Conclusions: The combined cyto-molecular parameter “GL1 Ca 72.4+” appears to be a strong indicator of aggressive tumor behavior and a significant prognostic factor of poor survival for GC patients.

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Section: Discussionmentioning

confidence: 99%

“…Categorical, ordinal, and continuous variables were compared using the χ 2 , Kruskal-Wallis, and Student t tests, respectively. Overall survival (OS) was evaluated as previously described [25]. Survival curves were created and compared resorting to the Kaplan-Meier method and the log-rank test, respectively.…”

Section: Methodsmentioning

confidence: 99%

Combined Analysis of Intragastric Malignant Exfoliation and Ca 72.4 Concentration in Stomach Adenocarcinoma: The “GL1 Ca 72.4” Parameter

et al. 2020

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“…Focusing on piRNAs, in a recent study, Zhou et al evaluated the role of piR-1245 as an indicator for GC. They obtained and AUC of 0.885 with a sensitivity value of 90.9%, obtaining better values than the traditional indicators for GC (CEA and CA724) [105].…”

Section: Other Noncoding Rnasmentioning

confidence: 94%

Biomarkers for Gastric Cancer Screening and Early Diagnosis

et al. 2021

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Gastric cancer is one of the most common cancers worldwide, with a bad prognosis associated with late-stage diagnosis, significantly decreasing the overall survival. This highlights the importance of early detection to improve the clinical course of these patients. Although screening programs, based on endoscopic or radiologic approaches, have been useful in countries with high incidence, they are not cost-effective in low-incidence populations as a massive screening strategy. Additionally, current biomarkers used in daily routine are not specific and sensitive enough, and most of them are obtained invasively. Thus, it is imperative to discover new noninvasive biomarkers able to diagnose early-stage gastric cancer. In this context, liquid biopsy is a promising strategy. In this review, we briefly discuss some of the potential biomarkers for gastric cancer screening and diagnosis identified in blood, saliva, urine, stool, and gastric juice.

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“…Interestingly, the expression of piR-1245 in gastric juice is higher in patients than in control individuals, with an AUC value of 0.885 [ 15 ]. Moreover, the expression of piR-1245 in gastric juice has the potential to be a noninvasive biomarker for gastric cancer detection and prognosis.…”

Section: Pirnas As Diagnostic and Prognostic Biomarkers In Cancermentioning

confidence: 99%

The biogenesis and biological function of PIWI-interacting RNA in cancer

et al. 2021

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Small non-coding RNAs (ncRNAs) are vital regulators of biological activities, and aberrant levels of small ncRNAs are commonly found in precancerous lesions and cancer. PIWI-interacting RNAs (piRNAs) are a novel type of small ncRNA initially discovered in germ cells that have a specific length (24–31 nucleotides), bind to PIWI proteins, and show 2′-O-methyl modification at the 3′-end. Numerous studies have revealed that piRNAs can play important roles in tumorigenesis via multiple biological regulatory mechanisms, including silencing transcriptional and posttranscriptional gene processes and accelerating multiprotein interactions. piRNAs are emerging players in the malignant transformation of normal cells and participate in the regulation of cancer hallmarks. Most of the specific cancer hallmarks regulated by piRNAs are involved in sustaining proliferative signaling, resistance to cell death or apoptosis, and activation of invasion and metastasis. Additionally, piRNAs have been used as biomarkers for cancer diagnosis and prognosis and have great potential for clinical utility. However, research on the underlying mechanisms of piRNAs in cancer is limited. Here, we systematically reviewed recent advances in the biogenesis and biological functions of piRNAs and relevant bioinformatics databases with the aim of providing insights into cancer diagnosis and clinical applications. We also focused on some cancer hallmarks rarely reported to be related to piRNAs, which can promote in-depth research of piRNAs in molecular biology and facilitate their clinical translation into cancer treatment.

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Gastric juice piR‐1245: A promising prognostic biomarker for gastric cancer

Cited by 25 publications

References 31 publications

Combined Analysis of Intragastric Malignant Exfoliation and Ca 72.4 Concentration in Stomach Adenocarcinoma: The “GL1 Ca 72.4” Parameter

Combined Analysis of Intragastric Malignant Exfoliation and Ca 72.4 Concentration in Stomach Adenocarcinoma: The “GL1 Ca 72.4” Parameter

Biomarkers for Gastric Cancer Screening and Early Diagnosis

The biogenesis and biological function of PIWI-interacting RNA in cancer

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