Gastric GIST or gastric schwannoma—A diagnostic dilemma in a young female

Abstract

HighlightsGastric Schwannoma is a rare neoplasm of stomach.It mimic clinically and radiologically with Gastric GIST.Immunohistochemical study can differentiate these two tumors.

Retrorectal schwannoma in a middle-aged female: A case report

“…Grossly, schwannomas can resemble GI stromal tumors (GISTs) as they are tan to white and well-circumscribed with a fibrous capsule [12] However, the histopathological picture can sometimes mimic other mesenchymal tumors such as GIST, leiomyoma, and leiomyosarcoma and these can be differentiated by the help of immunohistochemical (IHC) staining [13] . Histologically, schwannoma is positive for S-100 and negative for CD117, desmin, and actin [14] , [15] .…”

Laparoscopic resection of gastric schwannoma: A case report

“…Schwannomas are rare, benign mesenchymal tumors of the peripheral nerve sheath that arise from the Schwann cells; approximately 221 cases of gastric schwannomas have been reported worldwide [2] and they account for only 0.2% of all gastric tumors [3]. They occur most commonly between the fifth and sixth decades of life and tend to have a higher incidence in the female population [4].…”

“…They occur most commonly between the fifth and sixth decades of life and tend to have a higher incidence in the female population [4]. Although most gastric schwannomas are asymptomatic, some patients may experience dyspepsia, early satiety, fullness of stomach, heartburn, or abdominal discomfort as manifestation of the disease [3].…”

Gastric schwannoma: report of two cases and review of the literature

“…CT, MRI, and EUS of upper gastrointestinal, remaining as complimentary imaging studies in patients presenting without specific findings and the definitive diagnosis of gastric schwannomas is determined on the pathology report. Gastric schwannomas are uniquely different from other schwannomas in that they show similar attenuation on CT scans and that degenerative changes such as cystic changes are uncommon [7]. Furthermore, this homogenous enhancement pattern may also aid differentiating between gastric schwannomas and GISTs, since GISTs frequently show heterogeneous enhancement due to degenerative changes [7].…”

“…Gastric schwannomas are uniquely different from other schwannomas in that they show similar attenuation on CT scans and that degenerative changes such as cystic changes are uncommon [7]. Furthermore, this homogenous enhancement pattern may also aid differentiating between gastric schwannomas and GISTs, since GISTs frequently show heterogeneous enhancement due to degenerative changes [7]. MRI may provide further information about the exact location of the tumor and its relation to the surrounding structures.…”