Gastric foveolar metaplasia and gastric heterotopia in the duodenum: no evidence of an etiologic role for Helicobacter pylori

Genta, Robert M.; Kinsey, R. Shawn; Singhal, Anuradha; Suterwala, Smita

doi:10.1016/j.humpath.2010.04.010

Cited by 81 publications

(34 citation statements)

References 25 publications

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“…In our study, the presence of H. pylori infection and microscopic duodenitis were strongly related to each other, a finding that supports the limited evidence in the literature [21,22]. On the other hand, the presence of H. pylori infection also increased the severity of duodenitis and the latter resulted in aggravating the symptom severity in FD patients.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies reported various evidence in supporting [21,22] or fading out [18,23] the impact of H. pylori infection on producing histopathological duodenitis, but none of these studies concentrated solely on FD patients in this regard. Also, a meta-analysis focusing on eradication of H. pylori infection in FD patients continued to provoke controversies in treating H. pylori or not [28].…”

Section: Discussionmentioning

confidence: 99%

“…However, to the best of our knowledge, there is no study that evaluates the microscopic histopathological characteristics of the duodenum and its relationship to H. pylori infection and symptoms of patients with functional dyspepsia and almost all of the previous studies concentrated on gross histopathological changes in duodenal tissue [18][19][20][21][22][23]. Therefore, we decided to evaluate the relationship between microscopic duodenal tissue changes and H. pylori infection with symptoms of patients with functional dyspepsia to clarify the role of microscopic duodenitis in these patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Helicobacter pylori Infection and Microscopic Duodenal Histopathological Changes on Clinical Symptoms of Patients with Functional Dyspepsia

et al. 2011

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Helicobacter pylori Infection and Microscopic Duodenal Histopathological Changes on Clinical Symptoms of Patients with Functional Dyspepsia

et al. 2011

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“…One the other hand, HGM is the most reported epithelial heterotopia [11]. It is particularly found in the esophagus, duodenum, and ileum (Meckel's diverticulum) [12], with widely variable range of prevalence estimated from 0.1% atond 13.8% in the esophagus [13, 14] and 0.5% to 8.9% in the duodenum [15, 16]. …”

Section: Discussionmentioning

confidence: 99%

A Mass of Pancreatic and Gastric Heterotopia Causing a Small Bowel Obstruction in a 61-Year-Old Male

Alfrejat

Khalil

Jackobs

et al. 2017

Case Reports in Gastrointestinal Medicine

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Heterotopic tissue is a congenital anomaly that has been previously reported. Gastric and pancreatic heterotopia are among the most studied ones. Herein, we describe a case of a combined pancreatic and gastric heterotopia that formed a mass and caused a small intestine obstruction in a 61-year-old male. We also did a brief literature review of cases with gastric and pancreatic heterotopia in adult patients.

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“…One study showed that, compared to patients with normal duodenum, H. pylori infection is more common in patients with duodenal inflammation, which is a prerequisite of duodenal ulcer development, whereas patients with DGM had similar levels of H. pylori infection. 19 Thus, active duodenitis, but not DGM, is significantly associated with H. pylori infection. In addition, a study of H. pylori-positive patients with a duodenal ulcer or nonulcer dyspepsia failed to detect a significant correlation between gastric pH and the extent of DGM.…”

Section: Discussionmentioning

confidence: 96%

Helicobacter pyloriInfection and Duodenal Gastric Metaplasia in Healthy Young Adults

Seo

Park

et al. 2013

Korean J Gastroenterol

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Background/Aims: Duodenal ulcers occur relatively frequently in adolescents, like in adults, and may relate to Helicobacter pylori infection and duodenal gastric metaplasia (DGM). This study investigated the association between H. pylori infection and DGM in healthy adults aged 20-29. Methods: Between 1995 and 2005, endoscopic biopsies of the duodenum, antrum and body were taken from healthy, young volunteers, who were first-year medical students, faculty staff, residents, and research assistants of Gyeongsang National University in Jinju, Korea. Urease tests were performed and the extent of DGM and histopathological grades according to the Updated Sydney System were determined. Results: In total, 662 subjects were enrolled (429 males and 233 females). The median age was 22.3 years. The overall incidence of DGM was 11.5% but DGM was more frequent in males (15.4%) than in females (4.3%) (p＜0.0001). While H. pylori positivity rates changed significantly during the 1995-2005 period (p＜0.01), the incidences of DGM did not. DGM was observed in 7.2% and 14.9% of subjects who were and were not colonized with H. pylori, respectively. DGM was also associated with less severe chronic gastritis and the absence of active gastritis in both the antrum and body, and the absence of follicles in the antrum (p<0.05). Conclusions: These findings suggested that DGM is not rare in healthy young adults and is unrelated to gastric H. pylori infection. (Korean J Gastroenterol 2013;61:191-195)

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Gastric foveolar metaplasia and gastric heterotopia in the duodenum: no evidence of an etiologic role for Helicobacter pylori

Cited by 81 publications

References 25 publications

Impact of Helicobacter pylori Infection and Microscopic Duodenal Histopathological Changes on Clinical Symptoms of Patients with Functional Dyspepsia

Impact of Helicobacter pylori Infection and Microscopic Duodenal Histopathological Changes on Clinical Symptoms of Patients with Functional Dyspepsia

A Mass of Pancreatic and Gastric Heterotopia Causing a Small Bowel Obstruction in a 61-Year-Old Male

Helicobacter pyloriInfection and Duodenal Gastric Metaplasia in Healthy Young Adults

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