Gastric erosions following sympathetic denervation in the maternally deprived rat

Melinek, Menachem; Ackerman, Sigurd H.; Sharpless, Nansie S.; Hofer, Myron A.; Weiner, Herbert

doi:10.1016/0024-3205(79)90490-9

Cited by 5 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Details of this mechanism are not known nor is it known why under such conditions (S-SX) the lesion index is slightly elevated. An increase in gastric erosions after S-SX is, however, not a new observation [Melinek et al, 1979], Since with HSV sympathectomy is obligatorily involved [Holle, 1974], the rise in ulcer index following HSV in rats [Hanisch andSchwille, 1982] possibly can be explained on this basis.…”

Section: Discussionmentioning

confidence: 99%

Basal Gastric Secretion, Mucosal Blood Flow and Associated Fasting Blood Hormones in the Rat

Hanisch¹,

Schwille²,

Engelhardt³

1982

Eur Surg Res

View full text Add to dashboard Cite

After various types of sympathectomy (surgical, chemical, isolated adrenod-emedullation; AMX, combined procedurs) in the rat, basal gastric secretion, gastric mucosal blood flow (MBF), associated glucose and a variety of hormones in the blood were measured. With the exception of the ineffective surgical sympathectomy, all the other forms variously influence gastric secretion qualitatively (volume, acidity, pepsin) and quantitatively (output per unit time). Chemical sympathectomy has an augmenting effect both on acid (volume, acidity, output) and on pepsin. In general the MBF parallels acid, but the MBF is decreased after AMX despite stable or increased gastric secretion. Sympathectomy, except procedures involving AMX or AMX + surgical sympathectomy, increases spontaneous gastric mucosal lesions. With AMX glucose is diminished, but is elevated following surgical and chemical sympathectomy. Gastrin, insulin and somatostatin are always higher than in sham-operated controls, glucagon after surgical sympathectomy only. It is concluded that (1) the sympathoadrenal system in the rat modulates both basal gastric secretion and blood hormones; (2) the adrenal medulla may participate in the control of gastric MBF, and (3) gastric mucosal lesions are not correctly reflected by the ration MBF/acidity.

show abstract

Section: Discussionmentioning

confidence: 99%

Basal Gastric Secretion, Mucosal Blood Flow and Associated Fasting Blood Hormones in the Rat

Hanisch¹,

Schwille²,

Engelhardt³

1982

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…Levenstein’s work, however, reaffirms earlier research that this disease is multifactorial with clear psychosocial elements involved (9). Animal models clearly demonstrate the role of early life events such as time of weaning as a factor in disease onset (10). In human studies, life events, both early and recent, are more complex and have been imprecise in terms of the meaning attached to an event (11).…”

mentioning

confidence: 99%

Psychosomatic medicine: an approach needed now more than ever

Wise¹

2010

International Journal of Clinical Practice

View full text Add to dashboard Cite

Alpha adrenergic receptors and gastric function

Taylor

Mir²

1982

Drug Development Research

View full text Add to dashboard Cite

Taylor, J.A. and G. Nabi Mir: Alpha Adrenergic Receptors and Gastric Function. Drug Dev. Res. 2105-122,1982.Alpha-2 agonists by an effect on alpha-2 adrenoreceptors in the stomach (and probably in the brain also) suppress vagal nerve acetylcholine release thereby inhibiting gastric motility and secretion and inhibiting the development of gastric lesions in rats in the stress-, reserpine-, and cysteamine-induced ulcer models. Since the effects of the alpha-2 agonists are consistently inhibited by alpha-2 blocking agents, their effects appear to be selectively mediated via the alpha-2 receptor. It seems appropriate therefore that the role of the alpha-2 receptors be recognized in studies of gastric function and ulcer development.Address reprint requests to G .

show abstract

Gastric erosions following sympathetic denervation in the maternally deprived rat

Cited by 5 publications

References 21 publications

Basal Gastric Secretion, Mucosal Blood Flow and Associated Fasting Blood Hormones in the Rat

Basal Gastric Secretion, Mucosal Blood Flow and Associated Fasting Blood Hormones in the Rat

Psychosomatic medicine: an approach needed now more than ever

Alpha adrenergic receptors and gastric function

Contact Info

Product

Resources

About