Gastric epithelioid haemangioendothelioma

Tavares, Amélia; Almeida, Ana G.; Viveiros, Filipa; Cidade, Cassilda; Barbosa, Jorge Maciel

doi:10.1136/bcr.01.2011.3791

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…EHE rarely arises in the gastrointestinal tract where it has been described in the stomach, duodenum, and ileum. 8,9 Only one case of EHE has been described in the colon; however, images provided in the article do not show features characteristic of EHE and are more consistent with angiosarcoma. 10 None of the reported cases have been associated with concurrent disease of the bowel.…”

Section: Discussionmentioning

confidence: 77%

Epithelioid Hemangioendothelioma of the Bowel in Crohn’s Disease: The First Reported Case

et al. 2018

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Background. Epithelioid hemangioendothelioma (EHE) is an uncommon malignant endothelial neoplasm that most commonly arises in soft tissue, bone, lung, and liver. Crohn's disease (CD) is an inflammatory bowel disease of unknown etiology that is frequently associated with complications including strictures, fistulas/fissures, and neoplasms. Case description. A 43-year-old woman with a 6-year history of severe CD presented with anal pain and bleeding. She had prior partial colectomy for a stricture and a diverting ileostomy for perianal fissures and stricture. Colonoscopy showed severe chronic active colitis, stricture at 30 cm of anal verge, and a perianal fistula. The patient underwent total proctocolectomy. The colonic mucosa exhibited segmental ulceration and irregular thickening of the colon wall. Beneath an ulcer of the anal canal within the muscularis propria was a 1.2-cm poorly circumscribed, firm, white-tan mass. The mass was composed of cords and groups of large epithelioid endothelial cells with intracytoplasmic vacuoles enmeshed in a myxohyaline stroma. Immunohistochemically, the tumor cells were positive for ERG, CD31, and CAMTA1 and focally positive for keratin and SMA. Next-generation sequencing revealed a WWTR1-CMATA1 fusion. The morphology, immunoprofile, and molecular genetics were diagnostic of EHE. Discussion. Long-standing inflammatory bowel disease is associated with significant risk for developing neoplasms, usually carcinomas, which can be indistinguishable radiologically and clinically from nonneoplastic complications. These tumors are often identified as an incidental finding in specimens resected for clinically severe disease. This is the first report of EHE arising in the bowel affected by CD, and it mimicked mural fibrosis and fissures.

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Section: Discussionmentioning

confidence: 77%

Epithelioid Hemangioendothelioma of the Bowel in Crohn’s Disease: The First Reported Case

et al. 2018

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“…Gastric EHE has a predominance in females and in the sixth decade of life. This tumor usually presents a low malignant potential but sometimes may has an aggressive clinical course with metastatic evolution; the latest WHO classification calls EHE such "intermediate" or "borderline" neoplasms [12][13][14]. Clinical presentation can frequently include abdominal pain, sometimes with symptoms of gastric outlet obstruction if the mass increases in size and upper gastrointestinal bleeding due to ulceration and necrosis of the mucosa [10,15].…”

Section: Discussionmentioning

confidence: 99%

“…Although pleural EHE seems to respond to combination chemotherapy, including carboplatin and etoposide, its value in gastric EHE is not completely known. There is evidence to support the use of chemotherapy and targeted therapies specifically focusing on anti-angiogenesis; the current landscape of oncology with the emergence and excitement of immunotherapy could also translate into a role for immunotherapy in this disease [9][10][11][12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

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Gastric Epithelioid Haemangioendothelioma: A Case Report

Roberto¹,

Mocciaro²,

Bonaccorso³

et al. 2021

SCR

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Objective: To report a case of gastric epithelioid haemangioendothelioma, given its low incidence. Introduction: Epithelioid haemangioendothelioma is a vascular neoplasm composed of epithelioid or histiocytoid cells with endothelial characteristics. They have a very low incidence of approximately one per one million and are usually asymptomatic with a difficult preoperative diagnosis. Case Report: This study reports the case of a 58-year-old woman with a history of chronic anaemia. She underwent an elective upper endoscopy with evidence of an ulcerated submucosal lesion in the gastric antrum. The histological examination performed over the endoscopic biopsies showed the vascular characteristic of the tumor and endosonography confirmed the submucosal origin of the lesion. After resective surgery, the tumor showed the histological and immunohistochemical features of the epithelioid haemangioendothelioma. Conclusion: Surgery in the form of wide excision seems to be the treatment of choice for this rare neoplasm in the absence of histological markers of malignant potential.

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“…Hemangioendotheliomas which affects various parts of the digestive system ( 86 ) is classified into four types: Epithelioid hemangioendothelioma, spindle cell hemangioendothelioma, kaposiform hemangioendothelioma and endovascular papillary hemangioendothelioma (malignant tumor known as Dabska) ( 87 ). Gastric hemangioendotheliomas were rarely reported, only 5 cases, 2 of which were malignant tumors ( Table 2 ).…”

Section: Vascular Tumormentioning

confidence: 99%

The malignancy among gastric submucosal tumor

Yang¹,

Lu²

2019

Transl. Cancer Res.

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The origin and characteristics of most submucosal tumors (SMTs) cannot easily be confirmed by gastrointestinal endoscopy or other radiological examinations. Excluding GISTs, for those other gastric SMTs, most of which are deemed benign, the necessity and timing of intervention has been ignored. Thus, the malignancy of gastric SMTs still remains unknown. In order to summarize the malignancy of these gastric SMTs, we reviewed literatures and analyzed cases of gastric SMTs including heterotopic pancreas, leiomyoma, schwannoma, glomus tumor, hemangioendothelioma, granular cell tumor (GCT), lipoma, hemangiopericytoma, lymphangioma and neurofibroma. In these literatures, there are cases of malignancy among heterotopic pancreas, leiomyoma, schwannoma, glomus tumor, hemangioendothelioma and GCT. As a result, it suggests that although most of gastric SMTs are considered benign, there are still possibilities of malignancy, which requires our attention, even active intervention and long-term follow-up.

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Gastric epithelioid haemangioendothelioma

Cited by 5 publications

References 8 publications

Epithelioid Hemangioendothelioma of the Bowel in Crohn’s Disease: The First Reported Case

Epithelioid Hemangioendothelioma of the Bowel in Crohn’s Disease: The First Reported Case

Gastric Epithelioid Haemangioendothelioma: A Case Report

The malignancy among gastric submucosal tumor

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