Gastric emptying in patients with gastric and duodenal ulcer.

Kanaizumi, Toshifumi; Nakano, Hirofumi; Matsui, Taisuke; Tatsumi, Hidenori; Ishikawa, Hirofumi; Kuramoto, Hajime; Shimizu, Ryousuke; Shiratori, Tsuneo

doi:10.1620/tjem.158.133

Cited by 16 publications

(18 citation statements)

References 8 publications

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“…21 In 196 patients with duodenal ulcer disease, the median GET was increased significantly compared with normal control subjects. In patients with a history of peptic ulcer disease and deformed duodenal bulb, GET was 53 minutes in the absence of an 20 Kanaizumi et al 22 found RGE in patients with proximal gastric ulcers; however, in patients with a distal duodenal ulcer, the gastric emptying was delayed. Corinaldesi et al 23 found no relationship between ulcers and gastric acid output.…”

Section: Discussionmentioning

confidence: 98%

Clinical Significance of Rapid (Accelerated) Gastric Emptying

Singh¹,

Gull²,

Singh³

2003

Clinical Nuclear Medicine

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Section: Discussionmentioning

confidence: 98%

Clinical Significance of Rapid (Accelerated) Gastric Emptying

Singh¹,

Gull²,

Singh³

2003

Clinical Nuclear Medicine

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“…Kanaizumi et al (14) also found that the rate of gastric emptying as ulcers healed was closer to that in healthy subjects. The present study was performed on Day 3 following ulcer induction, in the active stage of the ulcer.…”

Section: Discussionmentioning

confidence: 77%

“…These findings would suggest that laparotomy, at least, should not have an influence on gastric emptying and that there are differences in the regions that influence gastric emptying. Kanaizumi et al (14) reported that proximal gastric ulcers enhanced, while distal gastric ulcers delayed, gastric emptying in patients with gastric ulcers, suggesting that the location of ulcer sites affects gastric emptying differently. This finding supports our present data.…”

Section: Discussionmentioning

confidence: 99%

Gastric emptying after artificial ulceration in rats: differences due to the site of the ulcer and the effects of prokinetic drugs

Uchida

Kobayashi

Shimizu

2017

J. Smooth Muscle Res.

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Background This study aimed to evaluate the effects of the position of an acetic acid-induced gastric ulcer and the effects of prokinetic drugs on gastric emptying. Materials and Methods Male Sprague-Dawley rats were used in this study. Acetic acid ulcers were induced either in the region between the fundus and pylorus on the anterior wall of the stomach or in the glandular region on the greater curvature of the stomach to determine whether there were regional differences in the effect of the ulcers. Gastric emptying was evaluated with a breath test using [1-13C] acetic acid. In addition, the effects of the prokinetic drugs, metoclopramide and mosapride, on gastric emptying were also evaluated. Results Acetic acid induced ulcers in the region between the fundus and pylorus on the anterior wall of the stomach significantly delayed gastric emptying as compared with control rats, but not the acetic acid induced ulcers in the glandular region on the greater curvature of the stomach. Metoclopramide and mosapride did not improve the delayed gastric emptying even at doses that enhanced gastric emptying in normal rats. Conclusion These findings show that gastric emptying is influenced by the position of the ulcer and the region between the fundus and pylorus on the anterior wall plays an important role in gastric emptying. Moreover, it was found that metoclopramide and mosapride do not improve the delayed gastric emptying caused by acetic acid ulcers induced on the anterior wall in the region between the fundus and pylorus.

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“…Previous studies of gastric emptying in peptic ulcer disease have shown that active gastric ulcer is associated with delayed gastric emptying [15,30], while active duodenal ulcer is associated with accelerated gastric emptying [15,16,17] compared with healthy subjects. However, Kanaizumi et al [31] have shown that for both gastric and duodenal ulcer, gastric emptying generally returned to normal when ulcers had healed.…”

Section: Discussionmentioning

confidence: 99%

Complicated and Uncomplicated Peptic Ulcer Disease: Altered Symptom Response to a Nutrient Challenge Linked to Gastric Motor Dysfunction

et al. 2014

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Background: Bleeding peptic ulcer (BPU) frequently occurs in the absence of preceding dyspeptic symptoms. We have observed that patients with BPU had a diminished symptom response to nutrient challenge test compared to uncomplicated peptic ulcer disease (uPUD). We postulated that more symptoms are manifest in patients with uPUD than BPU because there are greater derangements in gastric motor function. Aim: To assess gastric emptying in patients with BPU, uPUD and healthy controls (HC). Methods: We studied 17 patients with BPU, 10 with uPUD, and 15 HC. After an 8-hour fast, subjects ingested 200 ml of an enteral feeding solution, containing 5 MBq ^99mTc-rhenium sulphide colloid, every 5 min up to a cumulative volume of 800 ml. Gastric emptying was measured by scintigraphy for the total, proximal and distal stomach. Results: Patients with uPUD had significantly higher gastric retention in the proximal and total stomach at 100 min than HC and BPU, while BPU had similar percent retention to HC. Patients with uPUD had significantly higher cumulative symptom response to the nutrient challenge than did HC and BPU, while BPU had similar symptom responses to HC. Conclusions: Patients with uPUD have significantly delayed gastric emptying compared to HC and BPU. Data suggest that in addition to alterations of visceral sensory function, altered gastric motor function occurs during a nutrient challenge in uPUD but not BPU. Gastric motor function may contribute to the manifestation of dyspeptic symptoms in PUD.

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Gastric emptying in patients with gastric and duodenal ulcer.

Cited by 16 publications

References 8 publications

Clinical Significance of Rapid (Accelerated) Gastric Emptying

Clinical Significance of Rapid (Accelerated) Gastric Emptying

Gastric emptying after artificial ulceration in rats: differences due to the site of the ulcer and the effects of prokinetic drugs

Complicated and Uncomplicated Peptic Ulcer Disease: Altered Symptom Response to a Nutrient Challenge Linked to Gastric Motor Dysfunction

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