Gastric emptying in healthy children using the <i>Spirulina</i> breath test: The impact of gender, body size, and pubertal development

Kovacic, Katja; Zhang, Liyun; Liegl, Melodee; Pawela, Louis; Simpson, Pippa; Sood, Manu R.

doi:10.1111/nmo.14063

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…More recently, wireless motility capsules have been validated for use in children (≥8 years old) to evaluate GI motility and transit simultaneously (52). Noninvasive assessment of gastric emptying or whole gut transit show promise with the development of novel techniques such as the spirulina breath test (53).…”

Section: Less Invasive Investigative Toolsmentioning

confidence: 99%

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Chanpong

Thapar

2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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The field of pediatric neurogastroenterology and motility encompasses some of the most common and severe gastrointestinal (GI) disorders that affect children. GI motility disorders remain, in general, poorly understood, variably diagnosed, and inadequately treated. Although the field progressed relatively slowly over the last decades, the coming years will, no doubt, see it move into a prolific and dynamic era. With this review, we look forward to this brighter future for the field and highlight emerging areas that show promise and deserve focus in the coming years. This includes the role of early life programming and insult of the enteric neuromusculature as a key determinant of motility diseases and factors that are likely to be relevant in disease etiopathogenesis. We discuss several recent and futuristic developments and advancements in investigative and diagnostic tools as well as novel approaches that have been introduced in the management of GI motility disorders. These include targeted and personalized medicine in both pharmacological and multidisciplinary approaches as well as the emerging therapeutic options such as bioelectrical neuromodulation and regenerative medicine.

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Section: Less Invasive Investigative Toolsmentioning

confidence: 99%

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Chanpong

Thapar

2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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“…It involves the use of different labeled substances, such as 13C-octanoic acid [ 76 ] or 13C-spirulina platensis [ 77 ] for solids and 13C-acetate for liquids [ 78 ], to track their movement through the GI tract. When ingested, these labeled substances undergo metabolism in the small intestine and liver, leading to the production of 13C-containing metabolites.…”

Section: Diagnostic Pathways In Gastroparesismentioning

confidence: 99%

Imaging in Gastroparesis: Exploring Innovative Diagnostic Approaches, Symptoms, and Treatment

Mandarino

Testoni

Barchi

et al. 2023

Life

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Gastroparesis (GP) is a chronic disease characterized by upper gastrointestinal symptoms, primarily nausea and vomiting, and delayed gastric emptying (GE), in the absence of mechanical GI obstruction. The underlying pathophysiology of GP remains unclear, but factors contributing to the condition include vagal nerve dysfunction, impaired gastric fundic accommodation, antral hypomotility, gastric dysrhythmias, and pyloric dysfunction. Currently, gastric emptying scintigraphy (GES) is considered the gold standard for GP diagnosis. However, the overall delay in GE weakly correlates with GP symptoms and their severity. Recent research efforts have focused on developing treatments that address the presumed underlying pathophysiological mechanisms of GP, such as pyloric hypertonicity, with Gastric Peroral Endoscopic Myotomy (G-POEM) one of these procedures. New promising diagnostic tools for gastroparesis include wireless motility capsule (WMC), the 13 carbon-GE breath test, high-resolution electrogastrography, and the Endoluminal Functional Lumen Imaging Probe (EndoFLIP). Some of these tools assess alterations beyond GE, such as muscular electrical activity and pyloric tone. These modalities have the potential to characterize the pathophysiology of gastroparesis, identifying patients who may benefit from targeted therapies. The aim of this review is to provide an overview of the current knowledge on diagnostic pathways in GP, with a focus on the association between diagnosis, symptoms, and treatment.

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“…The slower rate of gastric emptying that has also been proposed to contribute to attenuations in glycaemia in response to breakfast consumption versus omission in adults (48) may, again, not apply equally to young people. Indeed, puberty, age and sex may affect gastric emptying in healthy children and adolescents, with slower rates reported in girls versus boys and during mid-late puberty versus pre-puberty (106) .…”

Section: Acute Breakfast Consumption-physical Activity Interactions F...mentioning

confidence: 99%

Enhancing cardiometabolic health through physical activity and breakfast manipulations in children and adolescents: good for humans, good for the planet

Zakrzewski-Fruer

Thackray

2022

Proc. Nutr. Soc.

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The human health benefits of cardiometabolic disease prevention can be accompanied by planetary co-benefits. Focusing efforts towards young people, including children and adolescents, is conducive to disease prevention. In the context of cardiometabolic disease prevention, this review paper critically summarises the available literature on the acute cardiometabolic responses to physical activity and breakfast manipulations among young people. Given the seriousness of global climate change, which will disproportionally affect our younger generations, the paper offers new insights into the inherent interactions between child-adolescent behaviour and cardiometabolic health from an environmental sustainability perspective to aid climate change mitigation efforts, including exploring future research avenues. A growing evidence base suggests acute moderate-to high-intensity exercise bouts can attenuate postprandial plasma glucose, insulin and triacylglycerol concentrations for up to 24-48 h in young people. Whether accumulating physical activity throughout the day with short, frequent bouts promotes cardiometabolic risk marker attenuations is unclear. Breakfast consumption may enhance free-living physical activity and reduce glycaemic responses to subsequent meals for a possible additive impact. If repeated habitually, attenuations in these cardiometabolic risk factors would be conducive to disease prevention, reducing the greenhouse gas emissions associated with disease diagnosis and treatment. To progress current understanding with high public health and planetary relevance, research among samples of 'at risk' young people that span cellular-level responses to ecologically valid settings and address human and planetary health co-benefits is needed. Indeed, certain physical activity opportunities, such as active travel to school, offer important direct co-benefits to human and planetary health.

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Gastric emptying in healthy children using the Spirulina breath test: The impact of gender, body size, and pubertal development

Cited by 5 publications

References 63 publications

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Imaging in Gastroparesis: Exploring Innovative Diagnostic Approaches, Symptoms, and Treatment

Enhancing cardiometabolic health through physical activity and breakfast manipulations in children and adolescents: good for humans, good for the planet

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