Gastric emptying in children with cerebral palsy and gastroesophageal reflux

Spiroglou, Kleomenis; Xinias, Ioannis; Karatzas, Nikolaos; Karatza, Elisa; Arsos, Georgios; Panteliadis, Christos P.

doi:10.1016/j.pediatrneurol.2004.02.007

Cited by 63 publications

(38 citation statements)

References 26 publications

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“…Several reports thus far have evaluated the normal value of t 1/2 in neurologically normal subjects analyzed by technetium-99m scintigraphy or 13 Coctanoic acid breath test analysis. 5 In the present study, the mean t 1/2 of all patients was 215.5 minutes and the t 1/2 of 24 (92.3%) patients were over 100 minutes. These results appear to be longer than those that previously reported.…”

Section: Discussionsupporting

confidence: 47%

“…1,2 Although the relationship between delayed gastric emptying (DGE) and GERD is still controversial, with some authors reporting a significant association between the 2 conditions 3,4 and others reporting no correlation, 5,6 several authors have described that the presence of DGE increases the probability and rate of gastroesophageal reflux (GER) episodes. [7][8][9][10] DGE has also been documented with an increasing frequency in infants and children with symptoms of GERD.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, a previous report evaluated by pH monitoring indicated that although a large proportion of NI patients manifest moderate to severe GERD and its complications, they do not have DGE. 5 Moreover, it remains unclear how the severity of DGE affects the aggravation of GERD. Twenty-four hour multichannel, intraluminal impedance pH measurements (pH/MII) have recently emerged as a novel technique to evaluate GERD irrespective of the pH value.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients

Ishii

Fukahori

Asagiri

et al. 2017

J Neurogastroenterol Motil

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Background/AimsThe aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and 13 C-acetate breath test ( 13 C-ABT) analyses. Methods 13C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD. At first, correlation analyses were performed to investigate the correlation between the 13 C-ABT parameters and the clinical or pH/MII parameters. Thereafter, all patients were divided into 2 groups (DGE and severe DGE [SDGE] group) according to each cut off half emptying time (t 1/2 , 90-170 minutes). Each pH/MII parameter was compared between the 2 groups in each set-up cutoff t 1/2 . ResultsThe mean t 1/2 of all patients was 215.5 ± 237.2 minutes and the t 1/2 of 24 (92.3%) patients were > 100 minutes. Significant moderate positive correlations were observed between both t 1/2 and lag phase time and the non-acid reflux related parameters. Furthermore, the patients in the SDGE group demonstrated higher non-acid reflux related parameters than those of the DGE groups when the cutoff was t 1/2 ≥ 140 minutes. ConclusionThe present study demonstrated that GE with t 1/2 ≥ 140 minutes was related to an increase of non-acid exposure reaching up to the proximal esophagus in NI patients, and indicating that NI patients with SDGE might have a high risk of non-acid GERD.

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients

Ishii

Fukahori

Asagiri

et al. 2017

J Neurogastroenterol Motil

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“…Quando associado a doenças como as neurológicas, é considerado secundário, como também relacionado a más-formações esofágicas, fibrose cística, pós-cirúrgico do trato digestivo alto e obesidade 52 . A DRGE é descrita em cerca de 20-90% da crianças com comprometimento neurológico 53 .…”

Section: Refluxo Gastroesofágicounclassified

Digestive tract neural control and gastrointestinal disorders in cerebral palsy

Araújo¹,

Silva²,

Mendes³

2012

J Pediatr (Rio J)

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Objectives: To examine the neural control of digestive tract and describe the main gastrointestinal disorders in cerebral palsy (CP), with attention to the importance of early diagnosis to an efficient interdisciplinary treatment.Sources: Systematic review of literature from 1997 to 2012 from Medline, Lilacs, Scielo, and Cochrane Library databases. The study included 70 papers, such as relevant reviews, observational studies, controlled trials, and prevalence studies. Qualitative studies were excluded. The keywords used were: cerebral palsy, dysphagia, gastroesophageal reflux disease, constipation, recurrent respiratory infections, and gastrostomy. Summary of the findings:The appropriate control of the digestive system depends on the healthy functioning and integrity of the neural system. Since CP patients have structural abnormalities of the central and peripheral nervous system, they are more likely to develop eating disorders. These range from neurological immaturity to interference in the mood and capacity of caregivers. The disease has, therefore, a multifactorial etiology. The most prevalent digestive tract disorders are dysphagia, gastroesophageal reflux disease, and constipation, with consequent recurrent respiratory infections and deleterious impact on nutritional status. Conclusions:Patients with CP can have neurological abnormalities of digestive system control; therefore, digestive problems are common. The issues raised in the present study are essential for professionals within the interdisciplinary teams that treat patients with CP, concerning the importance of comprehensive anamnesis and clinical examination, such as detailed investigation of gastrointestinal disorders. Early detection of these digestive problems may lead to more efficient rehabilitation measures in order to improve patients' quality of life.J Pediatr (Rio J). 2012;88(6):455-64: Cerebral palsy, dysphagia, gastroesophageal reflux disease, constipation. ResumoObjetivos: Abordar as peculiaridades do controle neuronal digestório e descrever as principais manifestações digestórias na paralisia cerebral, atentando-se à importância do diagnóstico precoce para intervenção interdisciplinar eficaz. Fontes dos dados:Revisão sistemática de 1997 a 2012 das bases de dados MEDLINE, LILACS, SciELO e Cochrane Library. Incluem-se 70 artigos, como revisões relevantes, estudos observacionais, ensaios clínicos e estudos de prevalência. Excluíram-se pesquisas qualitativas. Os termos pesquisados foram: paralisia cerebral, disfagia, doença do refluxo gastroesofágico, constipação intestinal, infecção respiratória e gastrostomia. Síntese dos dados:O controle adequado do trato digestório depende do funcionamento e integridade do sistema nervoso. Como indivíduos portadores de paralisia cerebral possuem anormalidades estruturais evidentes no sistema nervoso central e periférico, estão mais propensos a desenvolver distúrbios do trato digestório, com repercussões nutricionais. As alterações vão desde imaturidade neurológica até interferência do estado d...

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“…Varios estudios informan diferentes porcentajes de RGE en niños con PC, que van desde 24% a 86%, confirmados con exámenes, como monitorización por 24 horas del pH intraesofágico, gammagrafía, manometría esofágica, radiografía contrastada de esófago, etc. ( 7,15,[53][54][55][56][57] ). La gammagrafía dinámica de esófago realizada en uno de los niños demostró presencia de RGE y mediana probabilidad de aspiración bronquial (Figura 1).…”

Section: Discussionunclassified

Características nutricionales de niños con parálisis cerebral. ARIE - Villa El Salvador, 2004

Águila¹,

Áibar

2013

An Fac med

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Objetivos: Determinar la prevalencia y tipos de desnutrición en niños con parálisis cerebral (PC) e identificar problemas que conducen a ella. Diseño: Estudio clínico descriptivo. Lugar: Centro de Medicina y Rehabilitación Infantil ARIE, en el distrito de Villa El Salvador. Pacientes: Cincuenta y tres niños con PC que asistían para su rehabilitación. Intervenciones: La información clínica fue obtenida por entrevista con la madre y para el diagnóstico nutricional se utilizó la clasificación de Waterlow. Para el diagnóstico de anemia, se evaluó los valores de hemoglobina y hematocrito. La enteroparasitosis fue diagnosticada por examen directo de heces y examen de Graham, en forma seriada. El procesamiento de información y análisis estadístico se realizó utilizando el programa SPSS 11.0. Principales medidas de resultados: Presencia de desnutrición, dificultades para alimentación, reflujo gastroesofágico, anemia y enteroparasitosis. Resultados: Se encontró desnutrición en 81,1% de niños, siendo la desnutrición crónica el diagnóstico más frecuente, en 43,5%. Entre los problemas asociados a malnutrición, las dificultades para la alimentación estuvieron presentes en 94,3% de los niños y síntomas de reflujo gastroesofágico, en 81,1%. La prevalencia de anemia fue 32,4% y de enteroparasitosis, 54,1%. Conclusiones: Los niños con parálisis cerebral evaluados presentan una elevada prevalencia de desnutrición, relacionada al hallazgo frecuente de dificultades para la alimentación, reflujo gastroesofágico y enteroparasitosis. Este grupo de niños constituye una población de riesgo alto de morbilidad y mortalidad.

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Gastric emptying in children with cerebral palsy and gastroesophageal reflux

Cited by 63 publications

References 26 publications

Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients

Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients

Digestive tract neural control and gastrointestinal disorders in cerebral palsy

Características nutricionales de niños con parálisis cerebral. ARIE - Villa El Salvador, 2004

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