Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans

Calbet, José A. L.; Holst, Jens J.

doi:10.1007/s00394-004-0448-4

Cited by 246 publications

(230 citation statements)

References 51 publications

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“…Gluten protein hydrolysate, on the other hand, contained fewest BCAA and induced a rather low insulin response (only soy protein hydrolysate induced a lower insulin response) and the lowest glucagon response although these differences did not reach significance. This predictive effect of BCAA for insulin and glucagon secretion might also explain the discrepancy between the findings of our study and the study of Calbet and Holst (2004), since all the protein solutions in the latter study contained similar amounts of BCAA.…”

Section: Discussioncontrasting

confidence: 98%

“…Glucagon responses to pea and whey protein hydrolysate injection did not differ significantly in the study conducted by Calbet and MacLean (2002) which is in agreement with our findings. Calbet and Holst (2004) reported that whey and casein protein hydrolysate consumption induced similar insulin and glucagon responses suggesting that small differences in the amino-acid composition do not influence hormone secretion (Calbet and Holst, 2004). In this study, we found that amino-acid composition can influence hormone secretion and that this effect is more pronounced for glucagon than for insulin.…”

Section: Discussionsupporting

confidence: 55%

“…In addition to the direct glucagon-stimulating effect of amino acids (Kabadi, 1991;Claessens et al, 2007), the fall in glucose concentrations due to the higher insulin response induced by the carbohydrate/protein hydrolysate drinks might have contributed to the prolonged glucagon response. Hydrolysates of slowly digestible proteins such as casein may induce faster amino-acid and hormonal responses than the intact protein (Calbet and Holst, 2004;Lacroix et al, 2006). However, for hydrolysates of other proteins that are digested faster, such as whey protein, the difference is smaller Boza et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

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The effect of different protein hydrolysate/carbohydrate mixtures on postprandial glucagon and insulin responses in healthy subjects

Claessens

Calame²,

Siemensma³

et al. 2007

Eur J Clin Nutr

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Objectives: To study the effect of four protein hydrolysates from vegetable (pea, gluten, rice and soy) and two protein hydrolysates from animal origin (whey and egg) on glucagon and insulin responses. Subjects/Methods: Eight healthy normal-weight male subjects participated in this study. The study employed a repeatedmeasures design with Latin square randomization and single-blind trials. Protein hydrolysates used in this study (pea, rice, soy, gluten, whey and egg protein hydrolysate) consisted of 0.2 g hydrolysate per kg body weight (bw) and 0.2 g maltodextrin per kg bw and were compared to maltodextrin alone. Postprandial plasma glucose, glucagon, insulin and amino acids were determined over 2 h. Results: All protein hydrolysates induced an enhanced insulin secretion compared to maltodextrin alone and a correspondingly low plasma glucose response. A significant difference was observed in area under the curve (AUC) for plasma glucagon between protein hydrolysates and the maltodextrin control drink (Po0.05). Gluten protein hydrolysate induced the lowest glucagon response. Conclusions: High amino-acid-induced glucagon response does not necessarily go together with low insulin response. Protein hydrolysate source affects AUC for glucagon more profoundly than for insulin, although the protein load used in this study seemed to be at lower level for significant physiological effects.

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Section: Discussioncontrasting

confidence: 98%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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The effect of different protein hydrolysate/carbohydrate mixtures on postprandial glucagon and insulin responses in healthy subjects

Claessens

Calame²,

Siemensma³

et al. 2007

Eur J Clin Nutr

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“…Furthermore, whey hydrolysate has been found to elicit higher insulin responses compared with whole milk (Calbet and Maclean, 2002). Interestingly, although, comparison of oral administration of native whey protein and hydrolysed whey protein or hydrolysed casein revealed no differences in gastric emptying or appearance of amino acids in peripheral blood (Calbet and Holst, 2004). The different insulinotropic properties may on the other hand be attributed to differential stimulation of intestinal GIP secretion as demonstrated by Calbet and Holst (2004).…”

Section: Discussionmentioning

confidence: 92%

Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

et al. 2011

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Background/Objectives: Postprandial lipaemia is an established risk factor for atherosclerosis. To investigate the acute effect of four milk-derived dietary proteins (alpha-lactalbumin, whey isolate, caseinoglycomacropeptide and whey hydrolysate) on postprandial lipaemia, we have conducted a randomized, acute, single-blinded clinical intervention study with crossover design. Subjects/Methods: A total of 11 obese non-diabetic subjects (age: 44-74, BMI: 30-41.4 kg m -2 ) were included. On 4 different days the subjects ingested a high-fat meal with the following energy distribution: 66% energy from fat (100 g of butter), 15% of energy from carbohydrate (90 g of white wheat bread) and 19% of energy from protein (45 g of pure protein). Our primary variable was plasma triglyceride measured in the 8-h postprandial period. Secondarily, retinyl palmitate, non-esterified free fatty acids, glucose, insulin, glucagon, GLP-1 and GIP, active and total grehlin and cholecystokinin were measured. Results: We observed no statistically significant (P ¼ 0.8) differences between meals on our primary variable that is, triglycerides. Whey hydrolysate was associated with a significantly (P ¼ 0.02) smaller postprandial suppression of non-esterified free fatty acids compared with the other dietary proteins. Conclusion: We did not observe significant differences in postprandial lipaemia to the four milk-derived dietary proteins. Whey hydrolysate caused less postprandial suppression of free fatty acids.

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“…Milk proteins have been extensively investigated for their insulinotropic and glucose-lowering effects in healthy subjects (73,75,82,83,(90)(91)(92)(93)(94)(95)(96)(97)(98)(99) and to a limited extent in individuals with suboptimal glucose control (100)(101)(102)(103)(104)(105)(106) . The dose varied significantly between studies from as little as 10 g (92,105,106) -51 g (91) .…”

Section: Short-term Studies On Glycaemic Controlmentioning

confidence: 99%

Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials

2016

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The prevalence of cardiometabolic diseases is a significant public health burden worldwide. Emerging evidence supports the inverse association between greater dairy consumption and reduced risk of cardiometabolic diseases. Dairy proteins may have an important role in the favourable impact of dairy on human health such as blood pressure (BP), blood lipid and glucose control. The purpose of this review is to update and critically evaluate the evidence on the impacts of casein and whey protein in relation to metabolic function. Evidence from short-term clinical studies assessing postprandial responses to milk protein ingestion suggests benefits on vascular function independent of BP, as well as improvement in glycaemic homeostasis. Long-term interventions have been less conclusive, with some showing benefits and others indicating a lack of improvement in vascular function. During chronic consumption BP appears to be lowered and both dyslipidaemia and hyperglacaemia seem to be controlled. Limited number of trials investigated the effects of dairy proteins on oxidative stress and inflammation. Although the underlying mechanisms of milk proteins on cardiometabolic homeostasis remains to be elucidated, the most likely mechanism is to improve insulin resistance. The incorporation of meals enriched with dairy protein in the habitual diet may result in the beneficial effects on cardiometabolic health. Nevertheless, future well-designed, controlled studies are needed to investigate the relative effects of both casein and whey protein on BP, vascular function, glucose homeostasis and inflammation.

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Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans

Cited by 246 publications

References 51 publications

The effect of different protein hydrolysate/carbohydrate mixtures on postprandial glucagon and insulin responses in healthy subjects

The effect of different protein hydrolysate/carbohydrate mixtures on postprandial glucagon and insulin responses in healthy subjects

Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials

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