Gastric emptying evaluation in children with erosive gastroesophageal reflux disease

Machado, Rodrigo Strehl; Yamamoto, Erica; Patrı́cio, Francy Reis da Silva; Reber, Marialice; Kawakami, Elisabete

doi:10.1007/s00383-010-2579-4

Cited by 16 publications

(24 citation statements)

References 24 publications

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“…Therefore, we speculated that reducing DGE could be a target for treatment of GER in NI patients. However, our findings in this study revealed no significant association between DGE and GER, which is consistent with the recent literature [4,[18][19][20][21]. The mechanism responsible for the GER reduction caused by rikkunshito and laparoscopy-aided gastrostomy placement would not be the recovery of DGE, but it might be improvement in gastric accommodation.…”

Section: Discussionsupporting

confidence: 91%

“…Although DGE has been hypothesized to accentuate GER by increasing the volume of the refluxate and prolong TLESRs, the pathogenic role of DGE in GERD remains controversial [4]. Previous studies using various diagnostic tools, including esophageal pH monitoring, ultrasound, endoscopy, scintigraphy, and 13 C-breath test, found discrepant findings; some reports showed a correlation between DGE and GER [5][6][7][8][9][10] and some did not [4,[11][12][13][14][15][16][17][18][19][20][21]. Scintigraphy has been considered the gold standard for measuring gastric emptying; however, this technique is associated with radiation exposure to patients and personnel.…”

Section: Introductionmentioning

confidence: 99%

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Causal relationship between delayed gastric emptying and gastroesophageal reflux in patients with neurological impairment

et al. 2015

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Causal relationship between delayed gastric emptying and gastroesophageal reflux in patients with neurological impairment

et al. 2015

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“…In younger children, regurgitation and vomiting are commonly associated with cow's milk protein allergy and a gastric anaphylaxis resulting in both gastric dysrhythmia and delayed gastric emptying is described . While many earlier studies hypothesized that delayed gastric emptying exacerbates gastroesophageal reflux and the co‐existence of these conditions is appreciable, larger and more recent studies have refuted that theory and the role of gastroparesis in reflux remain controversial . Although delayed gastric emptying itself may be a pathogenic factor in gastroesophageal reflux in infants and children, the natural history and mechanism underlying this relationship remain poorly understood.…”

Section: Resultsmentioning

confidence: 99%

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Kovacic

Elfar

Rosen

et al. 2019

Neurogastroenterology Motil

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Background Due to scarcity of scientific literature on pediatric gastroparesis, there is a need to summarize current evidence and identify areas requiring further research. The aim of this study was to provide an evidence‐based review of the available literature on the prevalence, pathogenesis, clinical presentation, diagnosis, treatment, and outcomes of pediatric gastroparesis. Methods A search of the literature was performed using the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines with the following databases: PubMed, EMBASE, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, and Web of Science. Two independent reviewers screened abstracts for eligibility. Key Results Our search yielded 1085 original publications, 135 of which met inclusion criteria. Most articles were of retrospective study design. Only 12 randomized controlled trials were identified, all of which were in infants. The prevalence of pediatric gastroparesis is unknown. Gastroparesis may be suspected based on clinical symptoms although these are often non‐specific. The 4‐hour nuclear scintigraphy scan remains gold standard for diagnosis despite lack of pediatric normative comparison data. Therapeutic approaches include dietary modifications, prokinetic drugs, and postpyloric enteral tube feeds. For refractory cases, intrapyloric botulinum toxin and surgical interventions such as gastric electrical stimulation may be warranted. Most interventions still lack rigorous supportive data. Conclusions Diagnosis and treatment of pediatric gastroparesis are challenging due to paucity of published evidence. Larger and more rigorous clinical trials are necessary to improve outcomes.

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“…DGE primarily has not been associated with erosive esophagitis and GERD in recent pediatric literature 66,67 . Recent reports in adult patients did show that DGE does not affect outcomes of GERD following NF.…”

Section: Should Gastric Emptying Be Routinely Assessed Before Consmentioning

confidence: 97%

Barrett's esophagus: surgical treatments

Rosati

Savarino

Locatelli

et al. 2011

Annals of the New York Academy of Sciences

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The following on surgical treatments for Barrett's esophagus includes commentaries on the indications for antireflux surgery after medical treatment; the effects of the various procedures on the lower esophageal sphincter; the role of impaired esophageal motility and delayed gastric emptying in the choice of the surgical procedure; indications for associated highly selective vagotomy, duodenal switch, and gastric electrical stimulation; therapeutic strategies for detection and treatment of shortened esophagus; the role of antireflux surgery on the regression of metaplastic mucosa and the risk of malignant progression; the detection of asymptomatic reflux brfore bariatric surgery; the role of non-GERD symptoms on the results of surgery; and the indications of Collis gastroplasty and choice of the type of fundoplication.

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Gastric emptying evaluation in children with erosive gastroesophageal reflux disease

Abstract: Delayed gastric emptying is not associated with erosive esophagitis in children with GERD, when compared to controls.

Cited by 16 publications

References 24 publications

Causal relationship between delayed gastric emptying and gastroesophageal reflux in patients with neurological impairment

Causal relationship between delayed gastric emptying and gastroesophageal reflux in patients with neurological impairment

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Barrett's esophagus: surgical treatments

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