Gastric Emptying Delay and Gastric Electrical Derangement in IDDM

Cucchiara, Salvatore; Franzese, Adriana; Salvia, G.; Alfonsi, L.; Iula, Vita Dora; Montisci, A.; Moreira, Fernanda Dos Santos

doi:10.2337/diacare.21.3.438

Cited by 75 publications

(81 citation statements)

References 24 publications

(34 reference statements)

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“…Both bradygastria [25] and tachygastria [26] , conditions associated with delayed gastric emptying [27] , have been found after vasopressin stimulation in the human stomach. Altogether, these studies suggest that vasopressin and its receptors are involved in gastrointestinal motility, and the demonstration of vasopressin receptor mRNA in the gastrointestinal tract in this study may be related to this action.…”

Section: Discussionmentioning

confidence: 99%

Vasopressin Receptor mRNA Expression in the Human Gastrointestinal Tract

Monstein¹,

Truedsson

Ryberg

et al. 2007

Eur Surg Res

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Background/Aim: Vasopressin and oxytocin are closely related peptides, and both exert effects on the gastrointestinal function. In the present study, we wanted to map the expression of vasopressin receptor mRNAs (V1a, V1b/V3, and V2) in nontumorous tissue biopsy specimens of human gastrointestinal tract and surrounding tissues. Methods: Total and polyA+ RNAs were isolated from human tissue biopsy specimens using an automated nucleic acid extractor and, subsequently, converted into single-stranded cDNA. Seminested PCR amplifications were carried out, using gene-specific V1a, V1b/V3, and V2 receptor primers. The PCR amplicons were partially sequenced to confirm their identity. Results: The present study demonstrated the expression of vasopressin receptor mRNAs in human gastrointestinal tract, pancreas, kidney, lung, brain, and ovary. The expression pattern varied between different parts of the gastrointestinal tract. In the colon ascendens, V1a receptor mRNA expression could not be detected in 3 out of 4 analyzed tissue biopsy specimens. On the other hand, all the vasopressin receptor mRNAs were expressed in all colon transversum biopsy samples. Conclusions: V1a, V1b/V3, and V2 receptor mRNAs are widely expressed throughout human gastrointestinal tract and surrounding tissues. The data obtained provide information for further mapping and determination of the physiological role of the vasopressin receptor mRNA expression in normal and tumorous tissues.

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Section: Discussionmentioning

confidence: 99%

Vasopressin Receptor mRNA Expression in the Human Gastrointestinal Tract

Monstein¹,

Truedsson

Ryberg

et al. 2007

Eur Surg Res

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“…The reasons for the differences in gastric emptying rate and gastrin plasma concentrations in the three groups warrant discussion. Previous studies have shown that gastric emptying was delayed in symptomatic and asymptomatic diabetic patients with AN [4,11,[16][17][18]. Gastric emptying is abnormal in about 50% of diabetic patients, and delay in gastric emptying of nutrientcontaining meals is more common than rapid emptying [19].…”

Section: Discussionmentioning

confidence: 99%

Changes of gastric emptying rate and gastrin levels are early indicators of autonomic neuropathy in type II diabetic patients

Migdalis

Thomaides

Chairopoulos

et al. 2001

Clinical Autonomic Research

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The authors investigated the effect of a balanced meal on gastric emptying rate and gastrin plasma concentrations in patients with type II diabetes and autonomic neuropathy, in diabetic patients without autonomic neuropathy, and in healthy subjects (controls). Before food the gastrin plasma concentrations were higher in patients with diabetes with autonomic neuropathy. After food, gastric emptying rate was slower in patients with diabetes with autonomic neuropathy, whereas gastrin plasma concentrations increased in 30 minutes in all groups but to a greater extent in patients with diabetes with autonomic neuropathy. Sixty minutes after food, there was a significant decrease in gastrin plasma concentrations in patients with diabetes with autonomic neuropathy, compared with the other two groups. These data suggest that in patients with type II diabetes with autonomic neuropathy, food causes slower gastric emptying and different plasma gastrin level responses from those in patients with type II diabetes without autonomic neuropathy and controls. There are therefore differences in the responses to food ingestion between these groups because of vagal denervation induced by autonomic neuropathy. These tests should be reserved for patients with symptoms suggestive of disturbed gastric emptying, or for patients with autonomic neuropathy without symptoms of gastroparesis.

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“…Gastroparesis has been shown to be significantly correlated with a poor metabolic control in a population of T1D children with gastric electrical abnormalities. (Cucchiara et al, 1998). Furthermore it is conceivable that delayed gastric emptying may cause a mismatch between the onset of insulin action and the delivery of nutrients into the small intestine (Rayner et al, 2001).…”

Section: Gastropathymentioning

confidence: 99%