Gastric emptying after semi–solid food in multiple system atrophy and Parkinson disease

Thomaides, T.; Karapanayiotides, Theodoros; Zoukos, Y.; Haeropoulos, Costas; Kerezoudi, E.; Demacopoulos, Nikolaos; Floodas, Georgios; Papageorgiou, Eleni; Armakola, Filomeni; Thomopoulos, Yiannis; Zaloni, Ioanna

doi:10.1007/s00415-005-0815-y

Cited by 45 publications

(34 citation statements)

References 19 publications

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“…90%) compared to other dopamine agonists (10). In contrast, the pharmacokinetics of oral L-dopa largely depends on various factors, such as gastric emptying, which is known to be slow in MSA patients (11). This results in considerable variability among patients (12).…”

Section: Discussionmentioning

confidence: 98%

Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments

et al. 2013

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Multiple system atrophy with predominant parkinsonism (MSA-P) usually shows poor responsiveness to dopaminergic medications. We herein describe a patient with MSA-P who exhibited a good response to pramipexole but not to an ordinary dose of L-dopa. Positron emission tomography (PET) displayed severely impaired presynaptic dopaminergic availability and relatively preserved postsynaptic D2 receptor binding capacity. The pharmacokinetic analyses demonstrated relatively low bioavailability for L-dopa and adequate plasma levels of pramipexole, even at baseline, on a stable daily dose. The PET features and pharmacokinetic differences between L-dopa and pramipexole indicate the presence of unique therapeutic responses to dopaminergic medications in the patient.

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Section: Discussionmentioning

confidence: 98%

Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments

et al. 2013

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“…Among lower gastrointestinal symptoms, constipation is a common feature and a change in bowel habits suggests autonomic involvement of the lower gut [12]. Patients with MSA sometimes complain of upper gastrointestinal symptoms [2]. Gastrointestinal symptoms may be associated with reduced gastrointestinal motility due to autonomic nervous system dysfunction of MSA [2].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with MSA sometimes complain of upper gastrointestinal symptoms [2]. Gastrointestinal symptoms may be associated with reduced gastrointestinal motility due to autonomic nervous system dysfunction of MSA [2]. The previous study suggested that GE of patients with MSA was slower than the control [2].…”

Section: Discussionmentioning

confidence: 99%

“…Autonomic failure of MSA involves urinary incontinence or orthostatic hypotension [1]. Gastrointestinal symptoms are frequent complaints of patients with MSA and may be associated with reduced gastrointestinal motility due to autonomic nervous system dysfunction [2]. There is a report of gastric emptying (GE) in a small number of patients with MSA [2].…”

Section: Introductionmentioning

confidence: 99%

“…Gastrointestinal symptoms are frequent complaints of patients with MSA and may be associated with reduced gastrointestinal motility due to autonomic nervous system dysfunction [2]. There is a report of gastric emptying (GE) in a small number of patients with MSA [2]. Furthermore, there is no report on the correlation between GE and duration and severity of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the 13C-acetate breath test

et al. 2012

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Autonomic failure is one of the criteria according to the second consensus statement for the diagnosis of multiple system atrophy (MSA). Gastrointestinal symptoms are frequent complaints in patients with MSA and may be associated with reduced gastrointestinal motility due to autonomic nervous system dysfunction. However, there are few reports on gastric emptying in patients with MSA. We investigated gastric emptying in 25 patients with MSA, 20 patients with sporadic adult-onset ataxia of unknown etiology (SAOA), and 20 healthy volunteers using the (13)C-acetate breath test. Gastric emptying function is estimated by this test as the half-emptying time (HET) and peak time of the (13)C-%-dose-excess curve (T (max)), with expirations collected for 4 h after a test meal and determination of (13)CO(2) content using an infrared (IR) spectrophotometer. The HET and T (max) of gastric emptying were significantly delayed in patients with MSA as compared to those in SAOA and controls (p < 0.01). The HET and T (max) were not significantly different between SAOA and controls. No correlation existed between the HET or T (max) and the duration or severity of the disease in MSA patients. These results suggested that gastric emptying was significantly delayed in patients with MSA, and the delay already appeared in the early stage of the disease. Delayed gastric emptying is one of the autonomic failures and may be a clinical marker of MSA.

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Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders

Sanger

Broad

Alpers

2011

Peptide Drug Discovery and Development

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Gastric emptying after semi–solid food in multiple system atrophy and Parkinson disease

Cited by 45 publications

References 19 publications

Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments

Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments

Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the 13C-acetate breath test

Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders

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