Gastric Electrical Stimulation Optimized to Inhibit Gastric Motility Reduces Food Intake in Dogs

Guan, Song; Zhu, Hongbing; Lei, Yong; Yuan, Charlene; Starkebaum, Warren; Yin, Jieyun; Chen, Jiande D.Z.

doi:10.1007/s11695-014-1491-8

Cited by 11 publications

(29 citation statements)

References 43 publications

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“…Gastric stimulation protocols have also been applied to treat obesity by reducing motility, delaying emptying and increasing satiety. Pre-clinical trials showed that stimulation was able to delay gastric emptying, distention, and reduce food intake and eventually led to weight loss (Song et al, 2015). Initial trials in humans showed encouraging results Bohdjalian et al, 2006), but randomized trials have failed to show clinical benefit over a prolonged period (Shikora et al, 2009;Paulus et al, 2020).…”

Section: Gastric Stimulationmentioning

confidence: 99%

Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

et al. 2021

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Gastric pacing and stimulation strategies were first proposed in the 1960s to treat motility disorders. However, there has been relatively limited clinical translation of these techniques. Experimental investigations have been critical in advancing our understanding of the control mechanisms that innervate gut function. In this review, we will discuss the use of pacing to modulate the rhythmic slow wave conduction patterns generated by interstitial cells of Cajal in the gastric musculature. In addition, the use of gastric high-frequency stimulation methods that target nerves in the stomach to either inhibit or enhance stomach function will be discussed. Pacing and stimulation protocols to modulate gastric activity, effective parameters and limitations in the existing studies are summarized. Mathematical models are useful to understand complex and dynamic systems. A review of existing mathematical models and techniques that aim to help refine pacing and stimulation protocols are provided. Finally, some future directions and challenges that should be investigated are discussed.

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Section: Gastric Stimulationmentioning

confidence: 99%

Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

et al. 2021

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“…Basic laboratory research demonstrated that the failure of IGS in producing sufficient weight loss was attributed to its limited effects on the central satiety system and lack of effects on gastric motility, resulting from the use of narrow pulses (40). Most recent studies on GES with wide pulses designed to inhibit gastric motility has shown robust and significant effects on food intake and weight loss in both rats and dogs (41,42). Clinical studies are needed to prove the therapeutic potential of this method for treating obesity.…”

Section: Gastric Electrical Stimulation For Obesitymentioning

confidence: 99%

Gastrointestinal Electrical Neuromodulation for Functional Gastrointestinal Diseases, Obesity and Diabetes

Yin

Chen

2015

Bioelectron Med

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“…Various types of GES techniques have been studied over the past few decades in animals and humans 12,16 . Recently, inhibitory GES, that impairs gastric motility using trains of pulses with a width longer than 1 ms, has been considered the most promising method for inducing weight loss 16,18–20 . In rats and dogs, the pulse width was proven to be a key parameter related to gastric emptying, and hormonal and neural alterations, leading to a decrease in food intake 21–26 …”

Section: Introductionmentioning

confidence: 99%

“…Adapting the stimulation energy for each individual also appears to be a prerequisite for optimization of GES therapy 12,16,19,20,27 . In addition, for mid‐to‐long‐term therapy efficacy, habituation to GES (i.e., decrease in the response to stimulation over time) must be considered, as reported in dogs 19 and assumed in humans 27 .…”

Section: Introductionmentioning

confidence: 99%

Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

et al. 2021

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Background: Gastric electrical stimulation (GES) has been studied for decades as a promising treatment for obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations with regard to overcoming habituation to GES and inter-subject variation. This study aims to analyze the efficacy of an adaptive GES protocol for reducing food intake and maintaining lean weight in dogs.Methods: Six beagle dogs were implanted with a remotely programmable gastric stimulator. An adaptive protocol was designed to increase the stimulation energy proportionally to the excess of food consumption, with respect to the dogs' maintenance energy requirements. After surgery and habituation to experimental conditions, the dogs went through both a control and a stimulation period of 4 weeks each, in a randomized order. The stimulation parameters were adapted daily.Body weight, food intake, food intake rate, and postprandial cutaneous electrogastrograms (EGG) were recorded to assess the effect of adaptive GES. Results: Adaptive GES decreased food intake and food intake rate (p < 0.05) resulting in weight maintenance. In the absence of GES, the dogs gained weight (p < 0.05). Postprandial EGG dominant frequency was accelerated by GES (p < 0.05). The strategy of adapting the stimulation energy was effective in causing significant mid-term changes. Conclusion:Adaptive GES is effective for reducing food intake and maintaining lean weight. The proposed adaptive strategy may offer benefits to counter habituation and adapt to inter-subject variation in clinical use of GES for obesity.

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Gastric Electrical Stimulation Optimized to Inhibit Gastric Motility Reduces Food Intake in Dogs

Abstract: GES with appropriate parameters inhibits gastric motility, and the effects are reproducible. The GES method optimized to inhibit gastric motility reduces food intake in healthy dogs and may have a therapeutic potential for treating obesity.

Cited by 11 publications

References 43 publications

Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

Gastrointestinal Electrical Neuromodulation for Functional Gastrointestinal Diseases, Obesity and Diabetes

Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

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