Gastric Electrical Stimulation Is Associated With Improvement in Pancreatic Exocrine Function in Humans

Luo, Jiali; Al-Juburi, Amar; Rashed, Hani; O'Dorisio, Thomas M.; Marchal, Benoit; Starkebaum, Warren; Abell, Thomas L.

doi:10.1097/00006676-200408000-00017

Cited by 27 publications

(25 citation statements)

References 11 publications

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“…(vi) Modulation of the autonomic nervous system: There is evidence for enhanced vagal activity and decreased adrenergic effect. (29) and improved pancreatic exocrine function (30) in patients with pancreatic insufficiency.…”

Section: Discussionmentioning

confidence: 94%

Gastric Electrical Stimulation Significantly Increases Canine Lower Esophageal Sphincter Pressure

et al. 2005

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This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the greater curvature of the stomach. A sleeve device measured LES pressure before, during, and after GES, and regulatory peptides were measured during fasting and after a meal. A consistent and significant rise in LES pressure was observed during GES, and it was sustained after GES was discontinued. Plasma concentration and area under the curve of pancreatic polypeptide, motilin, gastrin and neurotensin were not affected by GES. We conclude that acute low- and high-frequency GES significantly increases LES pressure. This effect may not be modulated by efferent vagal activity or release of regulatory peptides.

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Section: Discussionmentioning

confidence: 94%

Gastric Electrical Stimulation Significantly Increases Canine Lower Esophageal Sphincter Pressure

et al. 2005

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“…[71][72][73][74][75][76][77][78][79][80][81] The most interesting finding in these studies was the dramatic improvement in nausea and vomiting. Depending on study centres, this improvement was noted in 60-75% of patients.…”

Section: Ges With Short Pulsesmentioning

confidence: 99%

Systematic review: applications and future of gastric electrical stimulation

Zhang

Chen

2006

Aliment Pharmacol Ther

105

114

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“…It has been hypothesized that the symptomatic improvement that has been observed is caused by modulation of enteric or afferent neural activity that consequently infl uences symptom perception or a central nausea and vomiting control mechanism [71] . Also, there have been recent reports indicating that GES therapy changes various electrogastrographic parameters, fundic relaxation, the autonomic nervous system, and gastrointestinal hormone levels [72][73][74] . Forster et al [75] could show that one third of patients with idiopathic and diabetic gastroparesis have absent cells of Cajal on full-thickness gastric biopsies, and that these patients have increased abnormalities of gastric slow waves and a more severe symptom status, as well as a poorer outcome with GES therapy.…”

Section: Resultsmentioning

confidence: 99%

Gastric Electrical Stimulation in Gastroparesis: Where Do We Stand?

Mönnikes

Voort

2006

Dig Dis

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Gastroparesis is a chronic disabling condition of impaired gastric motility that results in decreased quality of life. Currently available medical therapy consists of prokinetic and/or antiemetic therapy, dietary modifications, and nutritional supplementation. For patients with medication-resistant gastroparesis a non-pharmacological therapy, gastric electric stimulation, has evolved over the last decade. Based on the frequency of the electrical stimulus, gastric electric stimulation can be classified into low- and high-frequency gastric electric stimulation. The first method aims to normalize gastric dysrhythmia and entrain gastric slow waves and accelerates gastric emptying, whereas high-frequency gastric electric stimulation is unable to restore normal gastric emptying, but nevertheless stunningly reduces symptoms, such as nausea and vomiting, re-establishes quality of life, nutritional state in all patients, and metabolic control in patients with diabetic gastroparesis. Gastric electric stimulation presents a new possibility in the treatment of gastroparesis.

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Gastric Electrical Stimulation Is Associated With Improvement in Pancreatic Exocrine Function in Humans

Abstract: GES improves exocrine pancreatic release, effects autonomic control, and improves GI symptoms, suggesting a possible role for GES in the treatment of pancreatic insufficiency associated with gastroparesis.

Cited by 27 publications

References 11 publications

Gastric Electrical Stimulation Significantly Increases Canine Lower Esophageal Sphincter Pressure

Gastric Electrical Stimulation Significantly Increases Canine Lower Esophageal Sphincter Pressure

Systematic review: applications and future of gastric electrical stimulation

Gastric Electrical Stimulation in Gastroparesis: Where Do We Stand?

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