Gastric dysrhythmias and nausea of pregnancy

Koch, Kenneth L.; Stern, Robert M.; Vasey, Michael W.; Botti, John J.; Creasy, George W.; Dwyer, A.

doi:10.1007/bf01537244

Cited by 184 publications

(73 citation statements)

References 20 publications

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“…Gastric dysrhythmia has been observed in a number of clinical settings [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]and is known to be associated with gastric motility disorders [13]. It plays an important pathophysiological role in at least a subgroup of patients with gastroparesis.…”

Section: Discussionmentioning

confidence: 99%

“…Gastric dysrhythmia is used to describe the abnormal rhythmicity of the gastric slow waves and is classified into tachygastria, bradygastria and arrhythmia [1]. Gastric dysrhythmia has been observed in a variety of clinical studies [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13], including patients with unexplained nausea and vomiting [2, 3], gastroparesis [4, 5], type-II diabetes [6], early pregnancy [7, 8], gastroesophageal reflux disease [9], vagotomy [10], after surgery [11]and after bone marrow or stem cell transplantation [12]. …”

Section: Introductionmentioning

confidence: 99%

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Anti-Dysrhythmic Effects of Long-Pulse Gastric Electrical Stimulation in Dogs

Xu¹,

Qian²,

Chen³

2004

Digestion

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Background/Aim: The aim of this study was to investigate the anti-dysrhythmic effect of long-pulse gastric electrical stimulation (GES) in dogs. Methods: The study was performed in 7 healthy dogs implanted with 4 pairs of serosal gastric electrodes. Each dog was studied in three sessions on 3 separate days in a randomized order with recordings of gastric slow waves. In session 1 or 2, infusion of either saline or glucagon (0.1 U/kg in 20 ml saline instilled in 40 min) was given during the 2nd and 3rd 20-min periods. The protocol of session 3 was the same as that of session 2 except that GES was performed during the 2nd 20-min period. Results: (1) Glucagon induced gastric dysrhythmia and decreased gastric slow-wave coupling (ANOVA, p < 0.001). The long-pulse GES normalized glucagon-induced gastric dysrhythmia and the uncoupling of slow waves. (2) Glucagon induced symptoms and behaviors suggestive of nausea and the symptoms were not improved by long-pulse GES. Conclusion: (1) Glucagon induces gastric dysrhythmias, slow-wave uncoupling and symptoms, and (2) long-pulse GES normalizes glucagon-induced gastric dysrhythmia and slow-wave uncoupling with no improvement in symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Dysrhythmic Effects of Long-Pulse Gastric Electrical Stimulation in Dogs

Xu¹,

Qian²,

Chen³

2004

Digestion

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“…Several studies have previously suggested a possible association between nausea and gastric dysrhythmia [13, 14, 15, 16]. Regularization of the slow-wave frequency has been proposed as a possible explanation for the improvement in symptoms [12].…”

Section: Discussionmentioning

confidence: 99%

Gastric Electrical Stimulation in Intractable Symptomatic Gastroparesis

et al. 2002

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Background: The treatment of gastroparesis remains unsatisfactory despite prokinetic and anti-emetic drugs. Gastric electrical stimulation has been proposed as a therapeutic option. We have assessed the effect of gastric electrical stimulation on symptoms, medical treatment, body weight and gastric emptying in patients with intractable symptomatic gastroparesis in a non-placebo-controlled study. Methods: In this multicenter study, 38 highly symptomatic patients with drug-refractory gastroparesis were enrolled. Patients first received temporary electrical stimulation using percutaneous electrodes. The 33 responders to temporary stimulation then underwent surgical implantation of a permanent stimulator. Severity of vomiting and nausea was assessed before and after stimulation. Patients were reassessed 3, 6, and 12 months after permanent implantation. Results: With stimulation, 35/38 patients (97%) experienced >80% reduction in vomiting and nausea. This effect persisted throughout the observation period (2.9–15.6 months, 341 patient-months). Gastric emptying did not initially change, but improved in most patients at 12 months. At 1 year, the average weight gain was 5.5% and 9/14 patients initially receiving enteral or parenteral nutrition were able to discontinue it. Conclusion: Electrical stimulation of the stomach has an immediate and potent anti-emetic effect. It offers a safe and effective alternative for patients with intractable symptomatic gastroparesis.

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“…Myoelectrical abnormalities of the stomach have been recorded in patients with unexplained nausea and vomiting, during pregnancy or motion, and in patients with anorexia nervosa, and dysrhythmia seems to correlate with antral hypomotility and delayed gastric emptying. [9][10][11][12] Neonatal motility studies (in both preterm and term infants) have demonstrated impaired gastrointestinal motility, characterized by the presence of motor quiescence alternating with episodes of nonmigrating phasic activity without clear migrating Background. To evaluate the effect of feeding with milk on the gastrointestinal tract, we studied gastric electrical activity in 27 healthy fullterm newborns (15 formula-fed newborns and 12 breast-fed newborns) during the first 6 months of life.…”

Section: Introductionmentioning

confidence: 99%