2014
DOI: 10.1152/ajpgi.00258.2014
|View full text |Cite
|
Sign up to set email alerts
|

Gastric dysregulation induced by microinjection of 6-OHDA in the substantia nigra pars compacta of rats is determined by alterations in the brain-gut axis

Abstract: Toti L, Travagli RA. Gastric dysregulation induced by microinjection of 6-OHDA in the substantia nigra pars compacta of rats is determined by alterations in the brain-gut axis. Am J Physiol Gastrointest Liver Physiol 307: G1013-G1023, 2014. First published October 2, 2014; doi:10.1152/ajpgi.00258.2014.-Idiopathic Parkinson's disease (PD) is a late-onset, chronic, and progressive motor dysfunction attributable to loss of nigrostriatal dopamine neurons. Patients with PD experience significant gastrointestinal (G… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

4
48
1

Year Published

2015
2015
2021
2021

Publication Types

Select...
5
2

Relationship

1
6

Authors

Journals

citations
Cited by 47 publications
(53 citation statements)
references
References 61 publications
(89 reference statements)
4
48
1
Order By: Relevance
“…In these experiments, colonic tissues from 6-OHDA rats displayed a significant decrease in immunopositivity for ChAT, whereas the overall density of HuC/D1 myenteric neurons did not vary, suggesting that nigrostriatal denervation leads to a reduced expression of ChAT in myenteric cholinergic neurons, likely resulting in an impairment of colonic cholinergic neurotransmission. Of note, Toti and Travagli (2014) recently described a reduced density of ChAT1 myenteric neurons in the upper GI tract, without a concomitant variation of total neuronal density in 6-OHDA rats. In line with this picture, evidence of unchanged overall density of myenteric neurons was previously obtained in patients with PD, suggesting that PD-related GI dysmotility is not associated with a loss of neurons in the myenteric plexus but rather with alterations in the chemical coding of specific enteric neurons .…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…In these experiments, colonic tissues from 6-OHDA rats displayed a significant decrease in immunopositivity for ChAT, whereas the overall density of HuC/D1 myenteric neurons did not vary, suggesting that nigrostriatal denervation leads to a reduced expression of ChAT in myenteric cholinergic neurons, likely resulting in an impairment of colonic cholinergic neurotransmission. Of note, Toti and Travagli (2014) recently described a reduced density of ChAT1 myenteric neurons in the upper GI tract, without a concomitant variation of total neuronal density in 6-OHDA rats. In line with this picture, evidence of unchanged overall density of myenteric neurons was previously obtained in patients with PD, suggesting that PD-related GI dysmotility is not associated with a loss of neurons in the myenteric plexus but rather with alterations in the chemical coding of specific enteric neurons .…”
Section: Discussionmentioning
confidence: 89%
“…In particular, there is evidence that the vagus nerve exerts tonic anti-inflammatory actions and contributes to the maintenance of intestinal homeostasis (Matteoli and Boeckxstaens, 2013), whereas vagotomy confers an increased susceptibility to the development of inflammatory bowel diseases (Ghia et al, 2006). In addition, Toti and Travagli (2014) recently found a reduced expression of ChAT in the DMV of rats with 6-OHDA-induced nigrostriatal denervation. Based on this knowledge, it is conceivable that 6-OHDA-induced nigrostriatal denervation might impair the DMV-vagus nerve anti-inflammatory pathway, and that this alteration might result in a condition of mild chronic bowel inflammation, leading to persistent dysfunctions in the enteric neuromuscular compartment.…”
Section: Discussionmentioning
confidence: 99%
“…After 7 days of recovery, rats were anaesthetized, euthanized with a bilateral pneumothorax, perfused-fixed, and the midbrain at the level of the SNpc and medulla were processed for immunohistochemistry 16 (see below).…”
Section: Methodsmentioning
confidence: 99%
“…At the conclusion of the experiments, rats were euthanized, perfused-fixed, and brain and gastric tissues were harvested for immunohistochemistry and localization of microinjection sites 16 .…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation