“…11 From this point of view, many recent clinical studies, 12-14 reviews, 15,16 meta-analyses, [17][18][19][20][21][22][23] and guidelines [24][25][26] strongly recommended the use of EN compared with PN in the critically ill and surgical patients because of a lower infection rate or shorter duration of hospital stay with accompanying cost savings. Some randomized controlled trials (RCTs), [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] on the other hand, failed to demonstrate that there was statistical benefit to EN. The mechanisms explaining this benefit of EN over PN remain unknown.…”