Gastric carcinosarcoma, coexistence of adenosquamous carcinoma and rhabdomyosarcoma: a case report

Gastric carcinosarcoma presenting as a huge epigastric mass

“…At least 45 cases of gastric carcinosarcoma have been reported around the world [1][2][3][4][5][6][8][9][10][11][12][13][14][18][19][20][21][22][23][24][25][26][27], with the majority from Japan [13] (Table 2). As gastric carcinosarcoma is very rare, the effects of chemotherapy or radiotherapy have not yet been reported.…”

“…Histological identifi cation of the coexistence of carcinomatous and sarcomatous components in the tumor is indispensable for diagnosis. In all reported cases this coexistence has been confi rmed by using conventional hematoxylin and eosin (H&E) staining, with the additional use of immunohistochemical analyses in some cases [10,[12][13][14].…”

Variants of Gastric Carcinoma: Morphologic and Theranostic Importance

“…Due to this tumor detecting at advance stage and its rapid growth, most of SCSs are associated with a poor clinical outcome. Sato et al reported a mean survival of 10 months in patients with SCS [140]. The current standard therapy for SCS is partial or total gastrectomy with regional lymph node dissection.…”

“…SCS usually occurs in the antral or pyloric region and infiltrates the gastric wall frequently. Macroscopically, it is a polypoid, exophytic, or endophytic mass with ulceration ( Fig.14) [139,140,[142][143][144][145][146]. Histologically, SCS exhibits an adenocarcinoma component with variable differentiation and a high-grade sarcomatous component composed of spindle cells with high cellularity, frequent mitotic counts with atypical forms and pleomorphism (Fig.15).…”

“…The transition between epithelial and sarcomatoid components can be abrupt but two components may intermix with each other. The epithelial component is predominantly composed of adenocarcinoma but rarely adenosquamous and neuroendocrine cell carcinoma can be accompanied [82,83,140]. Some cases represent atrophic gastritis and dysplasia in the background gastric epithelium [142,145].…”