Gastric carcinoma with predominant choriocarcinomatous component

Nakao, Atsunori; Sakagami, K; Uda, Masashi; Mitsuoka, Shintaro; Yamashita, Naoto; Ito, Hisao

doi:10.1007/bf00539222

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…Ligation of the hepatic artery or hepatic lobectomy, or angioembolization could be an effective approach to cease the bleeding as a potentially life-saving measure. 18 There were some limitations to the present study. First, there were no sufficient data on hematoxylin and eosin staining or immunohistochemistry images, the topographic distribution of adenocarcinoma and choriocarcinoma components, the intermingled immunohistochemical features of these components, and the histology of lymph node metastases.…”

Section: Discussionmentioning

confidence: 86%

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Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Chen

Zou

et al. 2020

J Int Med Res

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The present study reports a rare case of a 65-year-old male patient with an exophytic ulcerative lesion in the gastric antrum. After performing a radical subtotal gastrectomy with D2 lymph node dissection and Billroth I gastrojejunostomy, histological analysis revealed a poorly differentiated adenocarcinoma combined with a biphasic pattern consisting of cytotrophoblasts and syncytiotrophoblasts. Immunohistochemical analysis showed a positive reaction with an anti-b-human chorionic gonadotropin antibody, and an abnormal increase in reproductive hormones. Furthermore, the patient succumbed to upper gastrointestinal hemorrhage in less than 3 months after the initial diagnosis, although the rupture of his liver metastasis was successfully treated by transhepatic artery embolization during the second admission.

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Section: Discussionmentioning

confidence: 86%

“…Ligation of the hepatic artery or hepatic lobectomy, or angioembolization could be an effective approach to cease the bleeding as a potentially life-saving measure. 18…”

Section: Discussionmentioning

confidence: 99%

Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Chen

Zou

et al. 2020

J Int Med Res

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“…Pure choriocarcinomas or carcinomas associated with choriocarcinomatous areas are most commonly seen in the uterus, followed by the gonads, mediastinum, retroperitoneum, and rarely in the stomach and remnant stomach. Primary gastric choriocarcinoma was first reported by Davidson in 1905 and accounts for 0.08% of all primary gastric cancers (3). To our knowledge, there have been no published reports concerning the choriocarcinomatous differentiation of adenocarcinoma in the gastric remnant.…”

Section: Introductionmentioning

confidence: 92%

Gastric adenocarcinoma with choriocarcinomatous differentiation in the remnant stomach, 54 years after Billroth II partial gastrectomy

Yıldırım

Erkan

Vardar

et al. 2016

JHSCI

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The gastric remnant cancer is defined as a cancer that has developed 5 or more years after distal gastric resection for benign diseases of the stomach. The choriocarcinomatous differentiation of adenocarcinoma in the stomach is a very rare tumor. A 75-year-old woman underwent resection of remnant stomach which she had operated for benign gastric pathology 54 years ago. Pathologic examination of the resection revealed areas of choriocarcinomatous differentiation in addition to classical adenocarcinoma. In the literature on English language, this report presents the first case of adenocarcinoma associated with choriocarcinomatous differentiation in the gastric remnant. The treatment of these patients depends on the clinical setting, and early diagnosis is an important factor for the treatment strategies. Therefore, due to the probability of arising adenocarcinoma in the remnant stomach, the patient should be investigated with endoscopic examination periodically, despite the long postoperative period.

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“…These hypotheses include origin from a gonadal angle displaced in the abdomen [14] , histological resemblance to choriocarcinoma [10] , origin from an underlying gastric teratoma [15] , and the retrodifferentiation or opisthoplatia of carcinoma cells to the level of the embryonal ectoderm with the ability to form trophoblasts [16] . The finding that gastric choriocarcinomas are frequently accompanied by adenocarcinoma is supported by this retrodifferentiation theory.…”

Section: Discussionmentioning

confidence: 99%

Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach

Hirano¹,

Hara²,

Nozawa³

et al. 2008

WJG

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We described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. An 85-year-old man visited our hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. Choriocarcinoma, small cell carcinoma and tubular adenocarcinoma existed in the gastric tumor. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic g o n a d o t r o p i n ( B -h C G ) a n d h u m a n p l a c e n t a l lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous foci contained cells positive for synaptophysin, neuron-specific enolase (NSE), and chromogranin A. The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 mo after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features.

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Gastric carcinoma with predominant choriocarcinomatous component

Cited by 9 publications

References 10 publications

Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Gastric adenocarcinoma with choriocarcinomatous differentiation in the remnant stomach, 54 years after Billroth II partial gastrectomy

Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach

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