Gastric carcinoma's primary presentation as multiple cutaneous nodules throughout the body

Bajoghli, Amir; Piselli, Alexandra; Kemprecos, Helen; Khosravi, Hamed; Cardis, Michael A.; Noel, Marcus Smith

doi:10.1016/j.ctarc.2022.100532

Cited by 5 publications

(7 citation statements)

References 12 publications

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“…Signet ring cell involvement has been believed to influence several tumor characteristics, including cancer aggressiveness, metastatic organotropism, and prognosis. 8 Similar to previously published cases of GC with signet ring cells, our patient had no metastatic involvement of the liver, lymph nodes, or peritoneum 9 (the most common metastatic sites in GC). Despite first-pass physiology and apparent hematogenous spread of this patient's cancer (evidenced by cutaneous and osseous involvement), he did not have active disease in the liver.…”

Section: Discussionsupporting

confidence: 88%

“…One potential reason for this is signet ring cell predilection towards bone and less commonly, skin. 9 Unfortunately, 10-year survival in patients with signet ring cell GC remains poor (∼16%) with a median survival time of 10.2 months. By the time most patients are diagnosed with signet ring cell GC, over 75% have poor grade differentiation and 74.1% of cases have regional (31.1%) or distant (43%) site involvement.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Cutaneous Gastric Adenocarcinoma With Signet Ring Cell Features

Garcia,

Maqsudlu,

Dhawa

et al. 2024

ACG Case Rep J

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Cutaneous metastatic disease from primary gastric cancer is quite scarce, often going unrecognized. In this case, the patient presented with an expanding rash that was biopsied, with findings concerning for metastatic adenocarcinoma from a suspected luminal upper gastrointestinal origin. Subsequent biopsies during an esophagogastroduodenoscopy confirmed poorly differentiated adenocarcinoma with signet ring cell features, most likely from an upper gastrointestinal primary (gastric vs gastroesophageal junction). We review this case to help providers identify signet cell type cutaneous metastases of gastric cancer quickly to improve patient outcomes.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

A Rare Case of Cutaneous Gastric Adenocarcinoma With Signet Ring Cell Features

Garcia,

Maqsudlu,

Dhawa

et al. 2024

ACG Case Rep J

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“…We found 13 cases in the PubMed database between 2014 and 2023 (Table 1 ). The most common site of cutaneous metastasis in GC is around the umbilicus and mainly occurs in males[ 2 , 3 , 5 , 13 , 17 ], and signet-ring cell carcinoma has a greater tendency[ 2 - 5 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous metastasis of GC is extremely rare, occurring in 0.2% to 1% of cases[ 2 - 4 ]. Cutaneous metastasis usually occurs in the late stage but sometimes appears as the first manifestation[ 5 - 9 ]. Single or multiple nodules are the most common clinical presentations[ 1 , 2 , 5 - 7 , 10 - 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cutaneous metastasis usually occurs in the late stage but sometimes appears as the first manifestation[ 5 - 9 ]. Single or multiple nodules are the most common clinical presentations[ 1 , 2 , 5 - 7 , 10 - 12 ]. In this paper, we report a patient with GC who developed cutaneous metastases with extensive redness and swelling, followed by skin thickening and nodules.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory cutaneous metastases originating from gastric cancer: A case report

Tian,

Ye,

et al. 2023

World J Clin Cases

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BACKGROUND Cutaneous metastasis with gastric cancer (GC) origin is extremely rare and associated with poor prognosis. Nodular type is the most common type, while other forms are extremely rare. CASE SUMMARY This study describes severe skin redness, swelling, pain, and fever in a 65-year-old man diagnosed with GC, whose left chest wall, left upper limb, and left back were mainly affected. Firstly, the patient was diagnosed with “lymphangitis” and treated to promote lymphatic return. However, the symptoms were constantly deteriorating, and skin thickening and scattered small nodules gradually appeared. Finally, the skin biopsy confirmed cutaneous metastases, and the patient died 7 d later. CONCLUSION Our case highlights that cutaneous metastasis should be considered when skin lesions appear in patients with GC.

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