Gastric Carcinoma in Young Adults

Abstract

Of 720 patients with gastric carcinoma treated over a 6-year period, 37 (5%) were 35 years of age or younger. They differed from older patients in that the usual sex ratio was altered (18 men: 19 women), and in certain histologic features. Poorly differentiated or undifferentiated lesions predominated (34 patients), and the distribution of histologic types was unusual; two thirds each were of the diffuse type (Lauren classification) or signet ring type (World Health Organization classification), and over three quarters were infiltrative (Ming classification). Intestinal metaplasia was absent in the majority of patients, and gastritis was less commonly seen than in older patients. Although most patients had long histories of disease and advanced disease, the TNM stages and the proportion undergoing curative resection (8%) were similar to those seen in older patients. Except for one who has survived 5 years, all patients in this study have died.

Lower survival rate for patients under 30 years of age and surgically treated for gastric carcinoma

“…Specifically, in patients under 30, the tumour was larger, the undifferentiated type was more frequent, the depth of serosal invasion was greater, the lymphatic involvement was more common, histologically infiltrative growth was prominent and the rate of peritoneal dissemination was higher. (Bloss et al, 1980) and the incidence of gastric cancer in younger patients has been consistent with gastric cancer in several series (Tso et al, 1987;Matley et al, 1988;Okamoto et al, 1988). 2.6% of our patients with gastric cancer were under 30 years of age, findings consistent with the data of Matley and colleagues (1988).…”

“…A high frequency of pregnancy in young women with gastric cancer has been noted (Bloss et al, 1980; Matley et al, 1988). As pregnancy most often occurs in this age group, the association could be fortuitous (Matley et al, 1988). The presence of estrogen receptors and intracytoplasmic estradiol in a proportion of patients of all ages fails to explain the preponderance of the female sex among these young cancer patients (Nishi et al, 1987).…”

“…It has been reported that only about 1-2% of all cases of gastric cancer occur in individuals aged 30 years or younger (Tso et al, 1987;Okamoto et al, 1988;Matley et al, 1988). The prognosis in these young patients has shown considerable variability, with the poor prognosis attributed to a delay in the diagnosis (Matsusaka et al, 1976;Bedikian et al, 1979;Bloss et al, 1980), and to a more aggressive course of disease (Tamura & Curtiss, 1960;Tso et al, 1987).…”

Estimation of Hazard Function and its Associated Factors in Gastric Cancer Patients using Wavelet and Kernel Smoothing Methods

“…Although in some studies, it proved that age is a significant factor in lifetime (Matley et al, 1988;Mitsudomi et al, 1989;Arveux et al, 1992;Maehara et al, 1995;Haugstvedt et al, 1993;Bucchi et al, 2004;Enzinger and Mayer, 2004;Saidi et al, 2004) there was no significant relationship between age and the lifetime in this study but, in some other studies there was shown that there is not a significant relationship between age and the lifetime (Khedmat et al, 2007;Biglarian et al, 2009;Roshanaei et al, 2010).…”

Prognosis for surgically treated gastric cancer patients is poorer for women than men in all patients under age 50

“…Several clinicopathological factors are involved in determining the prognosis for patients with a gastric cancer (Baba et tion could be fortuitous (Matley et al. 1988).…”