Gastric Carcinoma and Thyroid Status

Kandemir, Emin Gökhan; Yönem, Arif; Narịn, Yavuz

doi:10.1177/147323000503300210

Cited by 24 publications

(21 citation statements)

References 16 publications

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“…The data of epidemiological studies of coastal population of China and Japan with the highest in the world consumption of iodine (200 mg/daily/ per person due to excessive and harmful consumption of marine algae -sea-weeds) showed the highest rates of gastric cancer incidence (1). The data of Venturi et al (1,6) concerning the relation of iodine and gastric cancer were confirmed in study of Turkish investigators (56).…”

Section: Carcinogenicity Of Iodine and The Compounds Containing Iodinesupporting

confidence: 58%

Toxicology of iodine: A mini review

Il’in¹,

Nersesyan

2013

Arch Oncol

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Iodine is necessary for all living organisms. Deficiency of iodine in the organism leads to various diseases (including mental) and increased rates of cancer. It is well known that one third of the world's population lived in iodine-deficient areas. At present time, the primary intervention for preventing iodine deficiency disorders worldwide is through the iodization of salt. The two most common types of fortificant used to iodize salt are potassium iodide and potassium iodate. Iodine-containing compounds are also widely used in clinical medicine as a highly effective topical antimicrobial agent that has been used clinically in the treatment of wounds. Hence, the genetic toxicology of iodine and iodine-containing compounds is very essential topic. In this literature review are analyzed the data concerning genetic toxicology and the influence of these compounds on tumor rates in epidemiological and experimental studies.

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Section: Carcinogenicity Of Iodine and The Compounds Containing Iodinesupporting

confidence: 58%

Toxicology of iodine: A mini review

Il’in¹,

Nersesyan

2013

Arch Oncol

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“…This process is mediated by the Na + /I − symporter (15) and involves similar enzymes with an efficient peroxidase activity (12) (Table 1). Furthermore, besides its essential role for the synthesis of thyroid hormones, iodine regulates the proliferation of gastric mucosal cells (16).…”

Section: Thyroid and Stomach: Embryologic Derivation And Role Of Na+/mentioning

confidence: 99%

“…This notion is supported by the high percentage (12–40%) of positivity of PCA in adult patients with HT (9) which, in turn, is present in approximately 40% of patients with atrophic gastritis (10). Besides the fact that the thyroid and the stomach share some embryological and biochemical features (11), some intriguing similarities have been observed even in the putative pathogenic mechanisms, which characterize the thyrogastric syndrome (12). Furthermore, some specific clinical features characterize or lead to the suspicion of the coexistence of both thyroid and gastric autoimmune (13, 14) disorders.…”

Section: Introductionmentioning

confidence: 99%

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Cellini¹,

Santaguida²,

Virili³

et al. 2017

Front. Endocrinol.

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The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s. More recently, this association has been included in polyglandular autoimmune syndrome type IIIb, in which autoimmune thyroiditis represents the pivotal disorder. Hashimoto’s thyroiditis (HT) is the most frequent autoimmune disease, and it has been reported to be associated with gastric disorders in 10–40% of patients while about 40% of patients with autoimmune gastritis also present HT. Some intriguing similarities have been described about the pathogenic mechanism of these two disorders, involving a complex interaction among genetic, embryological, immunologic, and environmental factors. CAG is characterized by a partial or total disappearance of parietal cells implying the impairment of both hydrochloric acid and intrinsic factor production. The clinical outcome of this gastric damage is the occurrence of a hypochlorhydric-dependent iron-deficient anemia, followed by pernicious anemia concomitant with the progression to a severe gastric atrophy. Malabsorption of levothyroxine may occur as well. We have briefly summarized in this minireview the most recent achievements on this peculiar association of diseases that, in the last years, have been increasingly diagnosed.

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“…Immunoblotting studies showed that alterations in TRα protein levels often occur in human gastric cancer (GC) and are associated with distant metastasis [46]. Significant differences were found in the incidence of autoimmune thyroid disease between subjects with GC and control subjects, although neither hyperthyroidism nor hypothyroidism was significantly associated with GC [47]. Correspondingly, another study demonstrated that a substantial number of patients with GC developed antithyroid antibodies, although this was not always associated with diminished thyroid function [48].…”

Section: Gastric Cancermentioning

confidence: 99%

The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers

Brown

Simmen

2013

IJMS

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Thyroid hormones play a critical role in the growth and development of the alimentary tract in vertebrates. Their effects are mediated by nuclear receptors as well as the cell surface receptor integrin αVβ3. Systemic thyroid hormone levels are controlled via activation and deactivation by iodothyronine deiodinases in the liver and other tissues. Given that thyroid hormone signaling has been characterized as a major effector of digestive system growth and homeostasis, numerous investigations have examined its role in the occurrence and progression of cancers in various tissues of this organ system. The present review summarizes current findings regarding the effects of thyroid hormone signaling on cancers of the esophagus, stomach, liver, pancreas, and colon. Particular attention is given to the roles of different thyroid hormone receptor isoforms, the novel integrin αVβ3 receptor, and thyroid hormone-related nutrients as possible protective agents and therapeutic targets. Future investigations geared towards a better understanding of thyroid hormone signaling in digestive system cancers may provide preventive or therapeutic strategies to diminish risk, improve outcome and avert recurrence in afflicted individuals.

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Gastric Carcinoma and Thyroid Status

Cited by 24 publications

References 16 publications

Toxicology of iodine: A mini review

Toxicology of iodine: A mini review

Hashimoto’s Thyroiditis and Autoimmune Gastritis

The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers

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