Gastric cancer stem cells survive in stress environments via their autophagy system

Togano, Shingo; Yashiro, Masakazu; Masuda, Go; Sugimoto, Atsushi; Miki, Yuichiro; Yamamoto, Yasutake; Sera, Tomohiro; Komatsu, Shuhei; Nishimura, Shigeo; Kuroda, Kenji; Okuno, Tsunehisa; Ohira, Masaichi

doi:10.1038/s41598-021-00155-3

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…CSC Lgr5+ can promote the growth and proliferation potential of GC[ 30 ]. In addition, CSCs may maintain their viability through autophagy[ 31 ].…”

Section: Roles Of Cscs In Gcmentioning

confidence: 99%

Roles of cancer stem cells in gastrointestinal cancers

Xuan¹,

Hua²,

Xiang³

et al. 2023

World J Stem Cells

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Cancer stem cells (CSCs) are the main cause of tumor growth, invasion, metastasis and recurrence. Recently, CSCs have been extensively studied to identify CSC-specific surface markers as well as signaling pathways that play key roles in CSCs self-renewal. The involvement of CSCs in the pathogenesis of gastrointestinal (GI) cancers also highlights these cells as a priority target for therapy. The diagnosis, prognosis and treatment of GI cancer have always been a focus of attention. Therefore, the potential application of CSCs in GI cancers is receiving increasing attention. This review summarizes the role of CSCs in GI cancers, focusing on esophageal cancer, gastric cancer, liver cancer, colorectal cancer, and pancreatic cancer. In addition, we propose CSCs as potential targets and therapeutic strategies for the effective treatment of GI cancers, which may provide better guidance for clinical treatment of GI cancers.

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“…CSC Lgr5+ can promote the growth and proliferation potential of GC[ 30 ]. In addition, CSCs may maintain their viability through autophagy[ 31 ].…”

Section: Roles Of Cscs In Gcmentioning

confidence: 99%

Roles of cancer stem cells in gastrointestinal cancers

Xuan¹,

Hua²,

Xiang³

et al. 2023

World J Stem Cells

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“…Autophagy is activated in CSCs, and autophagy promotes the stemness of cancer cells [ 96 ]. Shingo Togano et al agreed that GCSCs survive in stress environments via their autophagy system [ 97 ]. Sarah Courtois et al found that autophagy induced by Helicobacter pylori infection is necessary for GCSCs emergence [ 98 ].…”

Section: The Role Of Protein-encoding Genes In Gcscsmentioning

confidence: 99%

Targeting Gastric Cancer Stem Cells to Enhance Treatment Response

Rao

Zhang

Luo

et al. 2022

Cells

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Gastric cancer (GC) was the fourth deadliest cancer in the world in 2020, and about 770,000 people died from GC that year. The death of patients with GC is mainly caused by the metastasis, recurrence, and chemotherapy resistance of GC cells. The cancer stem cell theory defines cancer stem cells (CSCs) as a key factor in the metastasis, recurrence, and chemotherapy resistance of cancer. It considers targeting gastric cancer stem cells (GCSCs) to be an effective method for the treatment of GC. For GCSCs, genes or noncoding RNAs are important regulatory factors. Many experimental studies have found that some drugs can target the stemness of gastric cancer by regulating these genes or noncoding RNAs, which may bring new directions for the clinical treatment of gastric cancer. Therefore, this review mainly discusses related genes or noncoding RNAs in GCSCs and drugs that target its stemness, thereby providing some information for the treatment of GC.

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“…A growing body of evidence suggests that autophagy can assist tumors in dealing with external pressures, such as hypoxia, nutrient shortage or cancer treatment, and then promote tumor progression ( 103 , 104 ). Similarly, under the environment of external stress, GCSCs have also been confirmed to sustain their cell activity through the autophagy system ( 105 ). Therefore, autophagy inhibitors are also considered as one of the potential therapeutic agents for cancer including GC.…”

Section: Potential Therapeutic Strategies For Gc: Targeting Gcscsmentioning

confidence: 99%

The origin of gastric cancer stem cells and their effects on gastric cancer: Novel therapeutic targets for gastric cancer

2022

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Gastric cancer (GC) is one of the most prevalent malignancies and the most common causes of cancer-related mortality worldwide. Furthermore, the prognosis of advanced GC remains poor even after surgery combined with chemoradiotherapy. As a small group of cells with unlimited differentiation and self-renewal ability in GC, accumulating evidence shows that GC stem cells (GCSCs) are closely associated with the refractory characteristics of GC, such as drug resistance, recurrence, and metastasis. With the extensive development of research on GCSCs, GCSCs seem to be promising therapeutic targets for GC. However, the relationship between GCSCs and GC is profound and intricate, and its mechanism of action is still under exploration. In this review, we elaborate on the source and key concepts of GCSCs, systematically summarize the role of GCSCs in GC and their underlying mechanisms. Finally, we review the latest information available on the treatment of GC by targeting GCSCs. Thus, this article may provide a theoretical basis for the future development of the novel targets based on GCSCs for the treatment of GC.

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Gastric cancer stem cells survive in stress environments via their autophagy system

Cited by 10 publications

References 24 publications

Roles of cancer stem cells in gastrointestinal cancers

Roles of cancer stem cells in gastrointestinal cancers

Targeting Gastric Cancer Stem Cells to Enhance Treatment Response

The origin of gastric cancer stem cells and their effects on gastric cancer: Novel therapeutic targets for gastric cancer

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