Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis

Sun, Li; Wang, Qianqian; Chen, Bin; Zhao, Yuanyuan; Shen, Bo; Wang, Hua; Xu, Jing; Zhu, Mengyi; Zhao, Xin; Xu, Changgen; Chen, Zhihong; Wang, Mei; Xu, Wenrong; Zhu, Wei

doi:10.1038/s41419-018-0988-9

Cited by 91 publications

(77 citation statements)

References 35 publications

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“…Ehninger et al showed that, although HSCs express low levels of the cMYC protein, its expression increases steadily during progenitor differentiation [39]. A recent study showed that IL-8 activates mTOR and increases endogenous cMYC production, inducing PDL1 expression in gastric cancer [40]. In this study, IL-8 significantly increased not only the number of CD34+ cells but also that of CD34+/CD45-cells.…”

Section: Regarding the Role Of Cmyc In Hematopoiesis Wilson Et Al Rsupporting

confidence: 55%

Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization

Kang

Lee²,

Kim³

et al. 2020

Preprint

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Abstract Background This study assessed the mechanism of hematopoietic stem cell (HSC) mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF) and determined how it differed from that using cyclophosphamide with G-CSF or G-CSF alone.Methods The study analyzed data from 173 non-Hodgkin’s lymphoma patients who underwent autologous peripheral blood stem cell transplantation (auto-PBSCT), in vitro experiments using HSCs and bone marrow stromal cells (BMSCs), and in vivo mouse model studies.Results The etoposide with G-CSF mobilization group showed the highest yield of CD34+ cells and the lowest change in white blood cell counts during mobilization. Etoposide triggered interleukin (IL)-8 secretion from BMSCs and caused long-term BMSC toxicity, which were not observed with cyclophosphamide treatment. The expansion of CD34+ cells cultured in BMSC-conditioned medium containing IL-8 was more remarkable than that without IL-8. The expression of CXCR2, mTOR, and cMYC in HSCs was gradually enhanced at 1, 6, and 24 h after IL-8 stimulation. In animal studies, the etoposide with G-CSF mobilization group presented stronger expression of IL-8-related cytokines and MMP9 and scantier expression of SDF-1 in the bone marrow, compared to the other groups not treated with etoposide.Conclusion Collectively, the unique mechanism of etoposide with G-CSF-mediated mobilization is associated with the secretion of IL-8 from BMSCs, causing the enhanced proliferation and mobilization of HSCs in the bone marrow, which was not observed in the mobilization using cyclophosphamide with G-CSF or G-CSF alone. Moreover, the long-term toxicity of etoposide to BMSC emphasizes the need for further studies to develop more efficient and safe chemo-mobilization strategies.

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Section: Regarding the Role Of Cmyc In Hematopoiesis Wilson Et Al Rsupporting

confidence: 55%

Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization

Kang

Lee²,

Kim³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…To mobilize BMDC, TSF stimulates the bone marrow compartment, switching it from a quiescent state to a highly pro‐angiogenic and pro‐tumorigenic state. The expansion and mobilization of BMDC expressing immune checkpoint ligands could be key immunosuppressive mechanisms by which, disseminating tumor cells escape immune surveillance …”

Section: Bone Marrow‐derived Cellsmentioning

confidence: 99%

Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery

Raskov

Orhan

Salanti

et al. 2020

Intl Journal of Cancer

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The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer surgery can increase survival, migration and proliferation of residual tumor cells. To secure the survival and growth of disseminated tumor cells, the formation of premetastatic niches in target organs involves a complex interplay between microenvironment, immune system, circulating tumor cells, as well as chemical mediators and exosomes secreted by the primary tumor. This review describes the current understanding of the early mechanisms of dissemination, as well as how surgery may facilitate disease progression.

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“…Similarly, microRNA-623 targeting of cyclin D1 also makes GC tumor cells more sensitive to 5-fluorouracil, thus improving the therapeutic effect of drugs [23]. GC mesenchymal stem cells can also promote the expression of PD-L1 through the STAT3/mTOR-c-Myc axis [24]. erefore, we performed western blot assays to observe the expression of cyclin D1 and c-MYC in different groups.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p

Jiang

Zhang

et al. 2020

BioMed Research International

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Circular RNAs are a class of endogenous noncoding RNAs that play an important role in gene regulation. These RNAs are involved in the development and progression of various cancers, but their roles in gastric cancer have not yet been thoroughly elucidated. This study showed that hsa_circ_0000467 expression was higher in gastric cancer tissues than in corresponding adjacent tissues (P<0.050) and that hsa_circ_0000467 expression levels were correlated with gastric cancer histological grade (P<0.050). In addition, hsa_circ_0000467 was remarkably upregulated in gastric cancer cell lines (P<0.001). Cell function experiments indicated that hsa_circ_0000467 downregulation decreased the proliferation and invasion ability of BGC-823 and SGC-7901 cells and the number of cells entering the G2/M phase. A direct binding interaction was detected between hsa_circ_0000467 and miR-326-3p by dual-luciferase reporter assays. In addition, the results showed that inhibition of miR-326-3p reversed the decreases in the proliferation and invasion of BGC-823 and SGC-7901 cells caused by hsa_circ_0000647 downregulation. Inhibition of miR-326-3p also decreased the number of cells entering the G2/M phase and the expression of cyclin D1. In conclusion, hsa_circ_0000467 plays a regulatory role in the development and progression of gastric cancer by regulating miR-326-3p, and this circRNA may be a potential diagnostic marker and therapeutic target of gastric cancer.

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Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis

Cited by 91 publications

References 35 publications

Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization

Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization

Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery

Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p

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