Gastric cancer in young Latin women: bad prognostic factors and outcomes

Calderillo-Ruiz, G.; Takahashi, A.; Herrera, María Del Carmen Méndez; Padilla, A.; Trejo, E.; Ramos‐Ramírez, Maritza; Carbajal, B.; Albarran, A.

doi:10.1093/annonc/mdz155.144

Cited by 6 publications

(5 citation statements)

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“…Retrospective studies with small sample sizes describe a preponderance of distal tumors (75-100%) and a variable rate of intestinal subtype (35-100%). A recent abstract on gastric cancer in Mexico found a 120% increase in incidence of young gastric cancer patients (32). Furthermore, 70% of patients had poorly cohesive tumors and 76% were stage IV upon presentation, which was significantly higher (thus more aggressive) than the 32.8% of poorly cohesive tumors and 47.7% rate of metastatic disease in our study.…”

Section: Surgical Cohortsupporting

confidence: 41%

Disparities and survival in newly diagnosed gastric cancer in Hispanic patients in the United States: a propensity score matched analysis

Tseng¹,

Miller²,

Johnson³

et al. 2021

J Gastrointest Oncol

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Background: The burden of gastric cancer involving Hispanic patients in the United States is growing as both the population and the incidence of gastric cancer in this group increases. This burden is compounded by presentation with advanced disease and socioeconomic challenges shaping cancer care. We sought to describe the demographics, socioeconomic factors, treatment, and survival experience of Hispanic patients with gastric adenocarcinoma.Methods: Patients with gastric adenocarcinoma diagnosed between 2004 and 2015 (n=90,737) in the National Cancer Database were retrospectively identified. Patients of Hispanic ethnicity were compared against non-Hispanic white patients. Surgical cohort was further analyzed, and 1:1 propensity score matching was used to balance covariates between Hispanic and non-Hispanic white surgical patients. Survival was compared using Kaplan-Meier method. Cox regression was used to determine prognostic factors for survival.Results: Compared to non-Hispanic white patients, Hispanic patients are more likely to be younger, female, and healthier. They were more likely to be uninsured, reside in poorer neighborhoods and reside in areas with lower rates of education. Hispanic patients were more likely to live in a metropolitan area, travel shorter distances for healthcare, and receive treatment at an academic and high volume centers. Hispanic patients were more likely to have higher stage disease presentation, higher grade tumors, lymphovascular invasion, and poorly cohesive adenocarcinoma. Hispanic patients were more likely to receive surgery, but less likely to receive adjuvant therapy. In Cox regression of all patients, unmatched surgical patients, and matched surgical patients, Hispanic ethnicity was an independent prognostic factor of improved survival.Conclusions: Hispanic patients with gastric adenocarcinoma present with several unfavorable clinicopathologic and socioeconomic factors. Paradoxically, these patients demonstrate improved survival.Further study is warranted to characterize disease biology in this population.

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Section: Surgical Cohortsupporting

confidence: 41%

Disparities and survival in newly diagnosed gastric cancer in Hispanic patients in the United States: a propensity score matched analysis

Tseng¹,

Miller²,

Johnson³

et al. 2021

J Gastrointest Oncol

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“…Balakrishnan and colleagues (10) reported that gastric cancer incidence remained stable among non-Hispanic whites and non-Hispanic blacks, but noted a significant rise in incidence among Hispanic adults in a cancer registry-based study among all patients across a single county in Texas. A recent retrospective study in Mexico examined clinicopathologic features of gastric carcinomas in Latin patients and noted an increased incidence of gastric cancer among patients age 40 years and younger compared with patients over the age of 40 years at diagnosis (5). Using the National Cancer Database, De and colleagues reported significant differences in race/ethnicity between individuals age younger than 40 years versus those 40 years of age and older diagnosed with gastric adenocarcinoma in a similar sized cohort, as Hispanic individuals were significantly more likely to be diagnosed with gastric adenocarcinoma at younger ages-concordant with our results (7).…”

Section: Discussionmentioning

confidence: 99%

Racial/Ethnic Patterns of Young-Onset Noncardia Gastric Cancer

Holowatyj

Ulrich

Lewis

2019

Cancer Prevention Research

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Increasing noncardia gastric cancer incidence rates among individuals age younger than 50 years have gained much attention, particularly as causes remain unknown. Using population-based NIH/NCI's Surveillance, Epidemiology, and End Results (SEER) program data from 2007 to 2015, multivariable logistic regression was used to quantify associations between race/ ethnicity and clinicodemographic features among young-onset noncardia gastric cancer patients. A total of 2,872 individuals ages 20 to 49 years were diagnosed with primary noncardia gastric cancer. Age at diagnosis, insurance status, anatomic subsite, American Joint Committee on Cancer (AJCC) clinical stage, histologic type, tumor grade, surgery, and county-level smoking prevalence differed by race/ethnicity (all P 0.003). Compared with non-Hispanic whites, Hispanics were more likely to be diagnosed at younger ages [odds ratio (OR) ¼ 0.97; 95% confidence intervals (CI), 0.95-0.99], on Medicaid/uninsured (OR ¼ 3.83; 95% CI, 2.89-5.08), diagnosed with higher grade tumors (OR ¼ 1.93; 95% CI, 1.32-2.84), and less likely to undergo surgery (OR ¼ 0.62; 95% CI, 0.44-0.88) or to reside in counties with higher smoking prevalence (OR ¼ 0.15; 95% CI, 0.11-0.21) after adjustment for sex, subsite, and histologic type. Asian/Pacific Islanders were more likely to be female (OR ¼ 1.40; 95% CI, 1.04-1.88), and less likely to be diagnosed with metastatic disease (OR ¼ 0.59; 95% CI, 0.37-0.95) or to reside in counties with higher smoking prevalence (OR ¼ 0.13; 95% CI, 0.08-0.19). Approximately two in every five patients with young-onset noncardia gastric cancer are Hispanic. Further investigation into the molecular heterogeneity of young-onset noncardia gastric cancers by race/ethnicity to understand etiologies underlying this rising disease epidemic is warranted. This population-based cohort study sheds light that biological and environmental factors may partly underlie race/ethnicity-related differences in youngonset noncardia gastric cancer susceptibility and outcomes. Patients and MethodsYoung-onset noncardia gastric cancer cases were identified using the NIH and NCI's Surveillance, Epidemiology, and End Results (SEER) program (11). The SEER program collects data on cancer incidence and mortality from 18

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“…Despite increases in certain cancers (like CRC) among the YA demographic, our study showed no trend toward increasing prevalence of GC in this subpopulation. The youngest group (18)(19)(20)(21)(22)(23)(24)(25) was associated with poor survival (median OS: 11.5 months) which is expected as cancers among these individuals tend to be more aggressive. 23 Delayed detection and/or rapid progression of GC in these patients are due in part to the absence of routine screening and genetic factors.…”

Section: Discussionmentioning

confidence: 95%

“…[10][11][12][13][14][15] Thislikelyreflectsthetrendthatamajorityof GC cases exist in East Asia and South America, where the overall incidence may be decreasing, but has been shown to be increasing among younger patients. [16][17][18][19] The subpopulation of young adults (YA) is of particular interest as these individuals can be overlooked when it comes to GC, and there are no guidelines for screening in the United States. 2 While it has been established that colorectal cancer (CRC) incidence has increased among YA and has contributed to an increased risk of mortality, the investigation of GC among YA is much less rigorous.…”

Section: Introductionmentioning

confidence: 99%

Age-Based Trends of Gastric Adenocarcinoma in the United States

Trumbull

Lemini

Elli

et al. 2020

The American Surgeon™

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Background Recent studies have shown an increase in the incidence of gastric cancer (GC) among young adults in Asia and Latin America. However, it is unknown if a similar trend is happening in the United States. Methods A retrospective review of the National Cancer Database was conducted to identify patients diagnosed with gastric adenocarcinoma between the years of 2004 and 2013. Results A total of 93 734 patients were included. The two age groups below 40 did not see a change in GC incidence; however, age groups above 40 had increasing incidence. Patients aged 18 to 25 had the largest proportion of stage 4 disease and a poor survival (median 11.5 months), compared to older patients. Conclusion Despite the increasing trend of GC among individuals, the incidence of GC among young adults is not increasing. However, this subpopulation presents at more advanced stages (clinical stage 4) and thus has worse survival.

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Gastric cancer in young Latin women: bad prognostic factors and outcomes

Cited by 6 publications

References 0 publications

Disparities and survival in newly diagnosed gastric cancer in Hispanic patients in the United States: a propensity score matched analysis

Disparities and survival in newly diagnosed gastric cancer in Hispanic patients in the United States: a propensity score matched analysis

Racial/Ethnic Patterns of Young-Onset Noncardia Gastric Cancer

Age-Based Trends of Gastric Adenocarcinoma in the United States

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