Gastric cancer in young adults

Stewart, P. D.; Holman, Russell L.

doi:10.1002/bjs.18004619819

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Likely also related to therapeutic advances are the improvements in survival among AYAs with lung, liver, pancreas, and stomach carcinomas (more prominent in males) [64][65][66][67]. Nevertheless, survival outcomes for these cancers in AYAs have remained relatively poor (<60%), which is characteristic for these cancer types regardless of patient age [52,[68][69][70][71][72]. Studies focusing on young patients (not necessarily AYAs), have shown that younger patients (aged < 50 years) with lung, liver, pancreas, and stomach carcinomas are more often diagnosed with more aggressive disease with higher grade, more advanced stage and higher metastatic rates when compared with older populations [64,65,[68][69][70][71][72].…”

Section: Lung Liver Pancreas and Stomach Carcinomasmentioning

confidence: 99%

“…Nevertheless, survival outcomes for these cancers in AYAs have remained relatively poor (<60%), which is characteristic for these cancer types regardless of patient age [52,[68][69][70][71][72]. Studies focusing on young patients (not necessarily AYAs), have shown that younger patients (aged < 50 years) with lung, liver, pancreas, and stomach carcinomas are more often diagnosed with more aggressive disease with higher grade, more advanced stage and higher metastatic rates when compared with older populations [64,65,[68][69][70][71][72]. This likely relates in part to delays in diagnosis and higher frequencies of driver mutations (e.g., EGFR and ALK mutations in lung cancer patients) [72][73][74].…”

Section: Lung Liver Pancreas and Stomach Carcinomasmentioning

confidence: 99%

“…In addition, survival outcomes for younger pancreatic and lung cancer patients did not improve drastically when treated with more aggressive treatment regimens [67,75]. This might explain why younger patients, in some studies, show similar or worse overall survival outcomes compared with older populations even though they generally suffer from less comorbidities and are better able to resist more intensive treatment regimens [65,68,69,72,73,76]. Considering the more aggressive disease biology and that younger patients have more potential life-years to lose, these cancers should receive increased attention in future research, as literature on these cancers among AYAs is scarce [9,65,[71][72][73].…”

Section: Lung Liver Pancreas and Stomach Carcinomasmentioning

confidence: 99%

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Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15–39 Years): A Population-Based Study in The Netherlands 1990–2016

Meer

Karim‐Kos

Mark

et al. 2020

Cancers

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Adolescent and young adult (AYA) cancer patients, aged 15–39 years at primary cancer diagnosis, form a distinct, understudied, and underserved group in cancer care. This study aimed to assess long-term trends in incidence, survival, and mortality of AYA cancer patients within the Netherlands. Data on all malignant AYA tumours diagnosed between 1990–2016 (n = 95,228) were obtained from the Netherlands Cancer Registry. European age-standardised incidence and mortality rates with average annual percentage change (AAPC) statistics and five-year relative survival rates were calculated. The overall cancer incidence increased from 54.6 to 70.3 per 100,000 person-years (AAPC: +1.37%) between 1990–2016, and increased for both sexes individually and for most cancer types. Five-year relative survival overall improved from 73.7% in 1990–1999 to 86.4% in 2010–2016 and improved for both sexes and most cancer types. Survival remained poor (<60%) for rhabdomyosarcoma, lung, stomach, liver, bladder, and pancreatic carcinomas, among others. Mortality rates among male AYAs overall declined from 10.8 to 6.6 (AAPC: −1.64%) and from 14.4 to 10.1 per 100,000 person-years (AAPC: −1.81%) for female AYAs since 1990. Mortality rates remained unchanged for male AYAs aged 20–24 and 25–29 years. In conclusion, over the past three decades, there has been a considerable increase in cancer incidence among AYAs in the Netherlands. Meanwhile, the survival improved and the mortality overall declined. Survival at five-years now well exceeds above 80%, but did not do so for all cancer types.

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Section: Lung Liver Pancreas and Stomach Carcinomasmentioning

confidence: 99%

Section: Lung Liver Pancreas and Stomach Carcinomasmentioning

confidence: 99%

Section: Lung Liver Pancreas and Stomach Carcinomasmentioning

confidence: 99%

See 1 more Smart Citation

Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15–39 Years): A Population-Based Study in The Netherlands 1990–2016

Meer

Karim‐Kos

Mark

et al. 2020

Cancers

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Tumor or Varices

Weylman¹,

Simon²

1961

JAMA

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Dr. William T. McCoy: A 31-year-old man was well until July of 1960, when he noted the onset of epigastric pain and nausea. On one occasion he vomited about a cupful of bright red blood. He was seen by his local physician and an upper gastrointestinal series was performed, and a duodenal ulcer diagnosed. He was treated for this, and remained much improved until some time later when amoebic enteritis was diagnosed and subsequently treated. In October the man again vomited blood, and an upper gastrointestinal series was performed Fig. 1.-Spot film; question of varices.Fig. 2.-Upper gastrointestinal x-ray. From the Weekly X-ray Seminar, Department of Radiology, Massachusetts General Hospital. Downloaded From: http://jama.jamanetwork.com/ by a University of Manitoba User on 06/09/2015

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Histopathological Analysis of Gastric Cancers in University of Ilorin Teaching Hospital: A 20-Year Review

Suleiman

Afolayan

Ibrahim

et al. 2021

J BioMed Res Clin Pract

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Gastric cancer is a relatively common malignancy in Nigeria. Gastric cancer varies from region, being 4th to 20th in proportion to other malignancies. The symptom and signs are often non-specific with the early stages of the disease. This may be responsible for late presentation and poor prognosis. This is a 20-year retrospective analysis of 107 histopathologically confirmed gastric cancers in the department of pathology. This study aimed to analyze the Histopathological patterns of all the gastric cancer cases diagnosed in U.I.T.H Ilorin, over a twenty-year period. Gastric cancers were classified according to WHO 2010 and Lauren classification of gastric cancers. A total of 107 cases of gastric cancers diagnosed, that met the inclusion criteria, were analyzed with male: female ratio of 1.3:1 out of which epithelial malignancy accounted for 93.5% with tubular adenocarcinoma representing the commonest epithelial subtype. Epithelial malignancy is the commonest histological type in this area. Therefore, it is recommended that patients above 40 years with dyspepsia and other alarm features should undergo routine endoscopic screening.

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Gastric cancer in young adults

Cited by 3 publications

References 8 publications

Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15–39 Years): A Population-Based Study in The Netherlands 1990–2016

Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15–39 Years): A Population-Based Study in The Netherlands 1990–2016

Tumor or Varices

Histopathological Analysis of Gastric Cancers in University of Ilorin Teaching Hospital: A 20-Year Review

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