Gastric cancer arising from the remnant stomach after distal gastrectomy: A review

Abstract

Gastric stump carcinoma was initially reported by Balfore in 1922, and many reports of this disease have since been published. We herein review previous reports of gastric stump carcinoma with respect to epidemiology, carcinogenesis, Helicobacter pylori (H. pylori) infection, Epstein-Barr virus infection, clinicopathologic characteristics and endoscopic treatment. In particular, it is noteworthy that no prognostic differences are observed between gastric stump carcinoma and primary upper third gastric cancer. In addition, endoscopic submucosal dissection has recently been used to treat gastric stump carcinoma in the early stage. In contrast, many issues concerning gastric stump carcinoma remain to be clarified, including molecular biological characteristics and the carcinogenesis of H. pylori infection. We herein review the previous pertinent literature and summarize the characteristics of gastric stump carcinoma reported to date.

Does remnant gastric cancer really differ from primary gastric cancer? A systematic review of the literature by the Task Force of Japanese Gastric Cancer Association

“…Therefore, it remains controversial whether there is any difference in the prognosis between the malignant and benign groups. Previous studies have revealed contradictory results regarding the 5-year survival rates between initial surgery for benign disease and that for malignant disease (Table 5) [8,29,34,36,57]. No significant difference in the stage distribution was found between the two groups, except for one study; Takeda et al…”

“…The risk of RGC is associated with the interval after gastrectomy and the type of reconstruction. These previous studies focused on whether remnant gastric cancer had an increased risk of carcinogenesis [8]. Thereafter, the discussion moved to whether RGC has a poorer prognosis than primary proximal gastric cancer (PGC).…”

DNA methylation genome-wide analysis in remnant and primary gastric cancers

“…Similarly, chronic inflammation has been reported to occur in the stomach especially during gastric carcinogenesis involving promoter gene hypermethylation [16][17][18]. However, the epigenetic events involving carcinogenesis in the remnant stomach during the development of remnant gastric cancer have been largely unexplored [19]. We hypothesized that there would be distinct differences in DNA methylation patterns that would occur during carcinogenesis of RGC and primary gastric cancer (PGC).…”

Carbon-14 urea breath test: does it work in patients with partial gastric resection?

“…or malignant causes [9][10][11]. The incidence of gastric stump cancer reached up to 2 % in this group [12]. As in non-operated patients, atrophic gastritis, intestinal metaplasia, dysplasia, and finally gastric cancer are closely related with the H. pylori infection in PGR patients [1].…”