Gastric cancer and Helicobacter pylori infection

F, Buruk; Berberoğlu, Uğur; I, Pak; Aksaz, Erol; Çelen, Orhan

doi:10.1002/bjs.1800800339

Cited by 35 publications

(11 citation statements)

References 20 publications

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“…Reports concerning the association of H pylori with histological types of gastric cancers are controversial. Some studies have shown an association between H pylori and intestinal type [2,30] , while others have observed a balanced distribution between the two histological types, like in the present work [31,32] . Some works have shown an association between Bcl-2 expression and EBV-positive gastric carcinomas [9] .…”

Section: Discussionsupporting

confidence: 61%

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Lima

Lima²,

André³

et al. 2008

WJG

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AIM: To investigate the interrelationship betweenH pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression.METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS:The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P = 0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori .However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION:The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

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Section: Discussionsupporting

confidence: 61%

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Lima

Lima²,

André³

et al. 2008

WJG

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“…After H. pylori infection becomes established, the gastric epithelium and the glands in the lamina propria are damaged both by direct bacterial toxicity and by the effects of inflammatory cell infiltration. Thus, chronic H. pylori infection may contribute to the process of mucosal destruction and regeneration in atrophic gastritis, with such changes being closely related to the occurrence of gastric cancer [3,32,33,34].…”

Section: Discussionmentioning

confidence: 99%

Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer?

Hamaguchi

Ogawa

Katšube

et al. 2004

Langenbeck's Archives of Surgery

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Before H. pylori eradication, the mucosa of the residual stomach may be at high risk of carcinogenesis due to induction of mucosal damage and active gastritis by H. pylori. Such changes were almost completely normalized by eradication therapy, so the eradication of H. pylori may reduce the risk of H. pylori-associated carcinogenesis in patients who have undergone gastrectomy for early gastric cancer.

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“…Tradicionalmente, la localización más frecuente del cáncer gástrico es la región antropilórica (cáncer gástrico distal) (5,6) , el cual se relaciona con el tipo histológico intestinal. Sin embargo, en las últimas décadas se ha observado un incremento de la frecuencia de los tumores de cuerpo y fondo (cáncer gástrico proximal) y de la unión esófago-gástrica (7)(8)(9) , lo cual se sospecha está asociado al cambio en la prevalencia también del tipo histológico de cáncer gástrico hacia el tipo difuso (10,11) .…”

Section: Introductionunclassified

Características histológicas y endoscópicas del cáncer gástrico diagnosticado en un hospital nacional del Callao, Perú

Rodríguez-Vargas¹,

Arévalo-Suarez²,

Salgado³

et al. 2013

Rev Peru Med Exp Salud Publica

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RESUMENObjetivos. Describir las características histológicas y endoscópicas que se presentan en pacientes diagnosticados con cáncer gástrico en el Hospital Nacional Daniel Alcides Carrión del Callao. Materiales y métodos. Se realizó un estudio tipo serie de casos que incluyó a todos los pacientes con diagnóstico histológico de cáncer gástrico durante el periodo de enero de 2009 a diciembre de 2011. La información se obtuvo de los registros del servicio de anatomía patológica del Hospital Nacional Daniel Alcides Carrión. Se consignó la edad y sexo de los pacientes, el tipo histológico, la localización endoscópica, así como la presencia de metaplasia intestinal, el grado histológico y la morfología del cáncer. Resultados. Se incluyeron 120 pacientes. La edad promedio fue de 65,4 ± 13,6 años; 59 (49%) fueron de sexo masculino. Según el tipo histológico se encontró el tipo intestinal en 68 (56%); difuso en 45 (38%), y mixto en 7 (6%). Según su localización, 23 (19%) se localizaron en fondo; 52 (43%) en el cuerpo; 39 (33%) en el antro, y 6 (5%) en el píloro. Los pacientes con cáncer gástrico de tipo intestinal presentaron una edad promedio mayor que los que tuvieron el tipo difuso (69,1 ± 10,3 versus 59,3 ± 15,3). De los pacientes con cáncer gástrico tipo intestinal, 60,3% tuvo localización proximal, en comparación a 66,6% de los pacientes con tipo difuso. Conclusión. En la población en estudio, el cáncer gástrico de tipo difuso se presenta a una edad más temprana que el de tipo intestinal, además de estar más frecuentemente localizados a nivel proximal. Palabras clave: Cáncer gástrico; Endoscopía; Histología; Patología; Metaplasia (fuente: DeCS BIREME). HISTOLOGIC AND ENDOSCOPIC CHARACTERISTICS OF GASTRIC CANCER DIAGNOSED IN A NATIONAL HOSPITAL OF CALLAO, PERU ABSTRACTObjetivos. To describe the histologic and endoscopic characteristics reported among patients diagnosed with gastric cancer in "Daniel Alcides Carrion" National Hospital in Callao. Materials and methods. We performed a case series including all patients with histological diagnosis of gastric cancer from January 2009 to December 2011. Data were obtained from the registers of the pathology service of Daniel Alcides Carrion National Hospital. Factors such as age and gender of patients, histologic type, endoscopic location, presence of intestinal metaplasia, histologic degree, and cancer morphology were evaluated. Results. 120 patients were included. Mean age was 65.4 ± 13.6 years; 59 (49%) were male. Based on the histologic type, intestinal type was found among 68 (56%); diffuse type among 45 (38%), and a mixed type in 7 (6%). Regarding the site, 23 (19%) of gastric cancers were located in the fundus; 52 (43%) in the body; 39 (33%) in the antrum, and 6 (5%) in the pylorus. Patients with gastric cancer of the intestinal type were in average older than those with a diffuse type (69.1 ± 10.3 versus 59.3 ± 15.3). 60.3% of intestinal-type gastric cancers were located proximally, versus 66.6% of diffuse-type cancers. Conclusion. Among the studied population, dif...

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Gastric cancer and Helicobacter pylori infection

Cited by 35 publications

References 20 publications

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer?

Características histológicas y endoscópicas del cáncer gástrico diagnosticado en un hospital nacional del Callao, Perú

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