Gastric cancer and concomitant renal cancer: A systematic immunohistochemical and molecular analysis

Betge, Johannes; Pollheimer, Marion J.; Schlemmer, Andrea; Höefler, Gerald; Langner, Cord

doi:10.3892/or.2011.1346

Cited by 4 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with reporter assay, we observed a strong decrease of KRAS expression in presence of miR-433 mimics, whereas the scramble had no effects in HGC-27 cells (Figure 4c). Previous studies have shown the importance of the KRAS/ERK signaling pathway in the regulation of cell migration, invasion and metastasis [15–17]. To investigate whether miR-433 could affect GC cell phenotype through the KRAS/ERK pathway, we examined the phosphorylation level of ERK in HGC-27 cells overexpressing miR-1433.…”

Section: Resultsmentioning

confidence: 99%

The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer

Guo

Wang

et al. 2013

IJMS

View full text Add to dashboard Cite

The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. Currently, the methylation epigenetic silencing of miRNAs with tumor suppressor features by CpG island hypermethylation is emerging as a common hallmark of different tumors. Here we showed that miR-433 and miR-127 were significantly down-regulated in gastric cancer (GC) tissues compared with the adjacent normal regions in 86 paired samples. Moreover, the lower level of miR-433 and miR-127 was associated with pM or pTNM stage in clinical gastric cancer patients. The restored expression of miR-433 and miR-127 in GC cells upon 5-Aza-CdR and TSA treatment suggested the loss of miR-433 and miR-127 was at least partly regulated by epigenetic modification in GC. Furthermore, the ectopic expression of miR-433 and miR-127 in gastric cancer cell lines HGC-27 inhibits cell proliferation, cell cycle progression, cell migration and invasion by directly interacting with the mRNA encoding oncogenic factors KRAS and MAPK4 respectively. Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future.

show abstract

Section: Resultsmentioning

confidence: 99%

The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer

Guo

Wang

et al. 2013

IJMS

View full text Add to dashboard Cite

show abstract

Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a case report and review of the literature

et al. 2020

View full text Add to dashboard Cite

Background Gastric carcinoma (GC) with second primary malignancy (SPM) is the most frequent combination within the multiple primary malignancies (MPM) group. The presentation of a GC associated with a synchronized SPM in the kidney is extremely rare and unusual. This study presents a rare case of synchronous tumors, describes the main associated risk factors, and emphasizes the need to rule out SPM. Main body We present the case of a 63-year-old Hispanic woman with a history of smoking, weight loss, and gastrointestinal (GI) bleeding. GC was diagnosed by endoscopy, and during her workup for metastatic disease, a synchronous SPM was noted in the left kidney. The patient underwent resection of both tumors with a satisfactory postoperative course. A systematic review of the literature was performed using the Medline/PubMed, Science Direct, Scopus, and Google Scholar databases. A search of the literature yielded 13 relevant articles, in which the following main risk factors were reported: the treatment utilized, the grade and clinical stage, histopathological report, and in some cases survival. It is concluded that advanced age (> 60 years) and smoking are the main associated risk factors. Conclusion Gastric carcinoma is the second most frequent neoplasm of the GI tract and the main neoplasm that presents a SPM. MPM screening is recommended in patients with gastric cancer. The clinical discovery of MPM of renal origin is rare and hence the importance of the current report.

show abstract

The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons

et al. 2022

View full text Add to dashboard Cite

Viral infections are major contributors to the global cancer burden. Recent advances have revealed that known oncogenic viruses promote carcinogenesis through shared host cell targets and pathways. The aim of this review is to point out the connection between several oncogenic viruses from the Polyomaviridae, Herpesviridae and Flaviviridae families and renal carcinogenesis, highlighting their involvement in the carcinogenic mechanism. We performed a systematic search of the PubMed and EMBASE databases, which was carried out for all the published studies on RCC in the last 10 years, using the following search algorithm: renal cell carcinoma (RCC) and urothelial carcinoma, and oncogenic viruses (BKPyV, EBV, HCV, HPV and Kaposi Sarcoma Virus), RCC and biomarkers, immunohistochemistry (IHC). Our analysis included studies that were published in English from the 1st of January 2012 to the 1st of May 2022 and that described and analyzed the assays used for the detection of oncogenic viruses in RCC and urothelial carcinoma. The virus most frequently associated with RCC was BKPyV. This review of the literature will help to understand the pathogenic mechanism of the main type of renal malignancy and whether the viral etiology can be confirmed, at a minimum, as a co-factor. In consequence, these data can contribute to the development of new therapeutic strategies. A virus-induced tumor could be efficiently prevented by vaccination or treatment with oncolytic viral therapy and/or by targeted therapy.

show abstract

Gastric cancer and concomitant renal cancer: A systematic immunohistochemical and molecular analysis

Cited by 4 publications

References 40 publications

The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer

The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer

Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a case report and review of the literature

The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons

Contact Info

Product

Resources

About