Gastric cancer & prospects of cancer in Saudi Arabia peninsula

Abstract

Gastric cancer is classified to be an aggressive disease with poor treatment outcome, as most cases remain undetected until later stages, wherein surgery and few chemotherapeutics become the only recommended treatment course. The process of cancer development is multistep involving many stages and types of precancerous lesions, and hence, routine monitoring becomes a necessity in those detected with these or exposed to risk factors. Studying the pattern of gastric cancer for any geographical region is also important to control mortality and focus on implementation of efficient management and treatment guidelines. The cause for gastric cancer can be genetic, racial as well as environmental, and hence the pattern of this malignancy differs across geographical regions and between the developing and the developed nations. In case of the Kindgom of Saudi Arabia, very few hospital-based reports have been published highlighting the pattern of gastric cancer, and the associated incidence and mortality rates. However, classified to be one of the most crucial cancer forms in Saudi Arabia, research pertaining to epidemiology, presentation and pathological features are limited. Studying gastric cancer occurrence from public health viewpoint is important also because eradication of causative agents like those that H. pylori has also shown been not reduce the risk of cancer development among individuals with atrophic metaplastic gastritis. In case of Saudi Arabia, many inherent risks for this malignancy exists like waterpipe smoking and shift in diet pattern from the traditional Mediterranean diet. Our review focusses on pattern of gastric cancer on a global scale in comparison to scenario in Saudi Arabia. The aim is to encompass all of the less stressed upon facts about this malignancy in the Kingdom, paving way for future work in this regards.

N6-methyladenosine (m6A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1

“…Gastric cancer (GC) is one of the most common cancers, meanwhile the second-leading fatal-related cancer worldwide [ 1 , 2 ]. Over the years, comprehensive treatments, including radiotherapy, chemotherapy, and surgery, have made great progress; however, the poor prognosis remains for GC patients and the 5-year survival rate is pessimistic [ 3 ].…”

A Case of Gastroesophageal Cancer after Laparoscopic Sleeve Gastrectomy

“…Gastric cancer is uncommon in Saudi Arabia. [5] Its incidence is decreasing worldwide due to the early detection and eradication of H.pylori infection, which is one of the most common independent risk factors.…”

FIP-nha, a fungal immunomodulatory protein from Nectria haematococca, induces apoptosis and autophagy in human gastric cancer cells via blocking the EGFR-mediated STAT3/Akt signaling pathway

“…Due to no specific clinical symptoms during the early stages, GC patients are always diagnosed in the advanced and metastatic stages ( Giuppi et al, 2021 , Zeinali et al, 2020 ). Besides, the high aggression and heterogeneity of GC make its treatment very difficult ( Abuderman, 2019 ). Chemotherapy has been indicated to be helpful in GC therapy.…”