Gastric cancer

Fernández–Fernández, Francisco José; Sesma, Pascual

doi:10.1016/s0140-6736(09)61947-4

Cited by 13 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PPIs are frequently given in patients who do not meet the criteria for appropriate use or for nonevidence‐based indications; inappropriate prescriptions are of particular concern among elderly patients who normally have multiple comorbidities, take many drugs, and are at higher risk of adverse drug reactions . Although generally well tolerated, PPIs can in fact cause serious adverse reactions, such as community‐acquired pneumonia, Clostridium difficile diarrhea, loss of efficacy of clopidogrel, hip fractures, severe hypomagnesemia with acute neurological manifestations, and delayed diagnosis of gastric cancer, and have been reported to increase all‐cause mortality …”

Section: Introductionmentioning

confidence: 99%

Overuse of proton pump inhibitors in nursing homes: An Italian multicenter observational study

Pasina

Novella

Elli

et al. 2020

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

Purpose: To examine the prevalence of residents receiving proton pump inhibitors (PPIs) for evidence-based indications in a large sample of Italian nursing homes (NHs) and to assess the predictors of potentially inappropriate prescriptions.Methods: This study was conducted in a sample of Italian long-term care NHs. Information on drug prescription, diseases, and socio-demographic characteristics of NH residents was collected three times during 2018. Appropriate use of PPI was defined in accordance with the strongest evidence-based indications and the Italian criteria for PPI prescription.Results: Among the 2579 patients recruited from 27 long-term care NHs, 1177 (45.6%) were receiving PPIs; 597 (50.7%) were taking them for evidence-based indications. Corticosteroids, anticoagulants, and mean number of drugs were the most important predictors of inappropriate PPIs prescriptions. NH residents receiving ≥13 drugs had about 10 times the risk of receiving a PPI than those taking 0 to 4 drugs.Similarly, residents with more comorbidity had about 2.5 times the risk of receiving a PPI than those in better health. The prevalence of residents inappropriately treated with PPI in individual NHs varied widely, ranging from 22% to 63%.Conclusions: Number of drugs, comorbidity, corticosteroids, and anticoagulants are the most important predictors of the inappropriate use of PPI in NHs. The wide variability between NHs in the appropriate use of PPIs suggests the need for thorough drug review in this fragile and vulnerable population. Prescribing patterns linked to evidence-based guidelines and national recommendations are essential for rational, cost-effective use of PPIs. K E Y W O R D Snursing homes, overuse, pharmacoepidemiology, proton pump inhibitors

show abstract

Section: Introductionmentioning

confidence: 99%

Overuse of proton pump inhibitors in nursing homes: An Italian multicenter observational study

Pasina

Novella

Elli

et al. 2020

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

show abstract

“…Gastric cancer (GC) is the second most frequent lethal malignancy worldwide; the metastasis of GC is primarily responsible for mortality. Early identification of metastasis and recurrence provides patients with time for salvage therapy in order to prolong their survival; thus, surveillance of GC metastasis risk factors has recently gained more attention 1, 2. It is widely accepted that morphological factors, such as Lauren classification and stromal volume (a term defined by the Japanese Gastric Cancer Association for the classification of GC according to the volume density of the cancer stromal area 3), are helpful for predicting GC metastasis, but are not sufficient 4, 5.…”

Section: Introductionmentioning

confidence: 99%

Strong YB‐1 expression is associated with liver metastasis progression and predicts shorter disease‐free survival in advanced gastric cancer

Yamada

Izumi

et al. 2012

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…Their short-term use has been associated with infections such as community-acquired pneumonia [18][19][20][21] or Clostridium difficile diarrhea [22,24] due to low gastric acidity, and with a loss of efficacy of clopidogrel as a result of drug interaction [25][26][27][28][29][30]. Longterm use has been related to increases in hip fractures [31][32][33], delayed diagnosis of gastric cancer and increased risk of all-cause mortality [34,35].…”

mentioning

confidence: 99%

Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly

Pasina

Nobili

Tettamanti

et al. 2011

European Journal of Internal Medicine

View full text Add to dashboard Cite

Background: Proton pump inhibitors (PPI) are among the most commonly prescribed medicines and their overuse is widespread in both primary and secondary care. Inappropriate prescription is of particular concern among elderly patients, who have often multiple comorbidities and need many drugs. Methods: We evaluate the appropriateness of drugs for peptic ulcer or gastro-esophageal reflux disease (GERD) in a sample of elderly patients (65 years old or older) at admission and discharge in 38 internal medicine wards between January 2008 and December 2008, according to the presence of specific conditions or gastro-toxic drug combinations. Results: Among 1155 patients eligible for the analysis, 466 (40.3%) were treated with drugs for GERD or peptic ulcer were at hospital admission and 647 (56.0%) at discharge; 62.4% of patients receiving a drug for peptic ulcer or GERD at admission and 63.2% at discharge were inappropriately treated. Among these, the number of other drugs prescribed was associated with greater use of drugs for peptic ulcer or GERD, even after adjustment for age, sex and number of diagnoses at admission (OR 95% CI = 1.26 (1.18-1.34), p = .0001) or discharge (OR 95% CI = 1.11 (1.05-1.18), p = 0.0003). Conclusions: Prevalence of inappropriate prescription of drugs for peptic ulcer or GERD remained almost the same at admission and discharge. Inappropriate use of these drugs is related to the concomitant use of other drugs. Careful assessment of clinical conditions and stricter adherence to evidence-based guidelines are essential for a rational and cost-effective use of drugs for peptic ulcer or GERD.

show abstract

Gastric cancer

Cited by 13 publications

References 5 publications

Overuse of proton pump inhibitors in nursing homes: An Italian multicenter observational study

Overuse of proton pump inhibitors in nursing homes: An Italian multicenter observational study

Strong YB‐1 expression is associated with liver metastasis progression and predicts shorter disease‐free survival in advanced gastric cancer

Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly

Contact Info

Product

Resources

About