Gastric bypass significantly improves quality of life in morbidly obese patients with type 2 diabetes

Abstract

Objective To evaluate the impact of Roux-en-Y gastric bypass (RYGB) on quality of life in obese diabetic patients compared to standard medical therapy for type 2 diabetes mellitus. Methods We prospectively studied two matched obese populations with type 2 diabetes. Thirty patients underwent laparoscopic RYGB and 31 received standard medical therapy combined with a diabetes support and education program (DSE), consisting of educational sessions on diet and exercise. Groups were matched by age, gender, weight, glucostatic parameters, and use of glucose-lowering medications (oral agents and insulin therapy). Health-related quality of life (HRQOL) was assessed using the normalized SF-36 questionnaire and data were collected at baseline and at 12-month follow-up. Results Diabetic patients who underwent RYGB experienced a statistically significant increase in their overall HRQOL. However, the role-physical and mental health domains increased but did not reach statistical significance. Diabetic patients in the medical therapy and DSE group did not show any significant increase in HRQOL. The between-group differences for the HRQOL changes from baseline were significant, other than for role-physical and mental health domains. Percentage changes in glucostatic parameters, discontinuation of glucose-lowering medications, and T2DM remission were not found to predict the percentage change in SF-36 scores at 12 months after RYGB. Conclusions For the first time, with a prospective matched control study, we demonstrate a significant improvement in HRQOL in obese diabetic patients who underwent RYGB, but not in those who were offered standard medical therapy and DSE.

Effects of a High-Intensity Exercise Program on Weight Regain and Cardio-metabolic Profile after 3 Years of Bariatric Surgery: A Randomized Trial

“…Along with these physiological responses, improvements were observed in the quality of life of participants who performed the exercise program, especially in the physical scales of the SF36 questionnaire. Many studies have reported short-term improvements in quality of life after BS, both in the physical and mental scales 43 . However, these effects are lost in the long-term, especially in the physical domains 44,45 .…”

Racial Disparity in 30-Day Outcomes of Metabolic and Bariatric Surgery

“…Obesity is a chronic disease with a globally rising rate that reached 30.1% in 2017 [1]. Metabolic and bariatric surgery has been proved to be the most effective method not only for weight loss [2,3] but also for resolving or improving associated comorbidities [4][5][6][7] and quality of life as well as longterm mortality in obese patients [8].…”

Long-term impact of the metabolic status on weight loss-induced health benefits

“…It makes this study population to some extent comparable to our metabolically ill MUO subgroup, although a preexisting diabetes was not mandatory in our MUO subjects. However, data regarding the effect of an identical weight loss/weight maintenance intervention on estimates of QoL in MUO and MHO has currently not yet been available, even if QoL has developed into an important outcome measure of weight loss therapies in general [ 24 , 25 ]. It is of particular relevance for real-world settings, where changes in physical function strongly affect daily life and will therefore result in improved well-being.…”