Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-α. Prospective Clinical Trial

Viana, Elaine Cristina; Araujo-Dasilio, Karine L.; Miguel, Gustavo Peixoto Soares; Bressan, Josefina; Lemos, Elenice Moreira; Moysés, Margareth Ribeiro; Abreu, Gláucia Rodrigues de; Azevedo, João Luiz Moreira Coutinho; Carvalho, Perseu Seixas de; Passos‐Bueno, Maria Rita; Errera, Flávia Imbroisi Valle; Bissoli, Nazaré Souza

doi:10.1007/s11695-013-0894-2

Cited by 69 publications

(58 citation statements)

References 46 publications

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“…The LRYGB-induced decline in biomarkers of systemic inflammation is wellestablished in available literature (9)(10)(11)(12) . Our results identify a time-course of changes in pro-and anti-inflammatory cytokines with potentially relevant pathophysiological implications.…”

Section: Basalmentioning

confidence: 95%

“…Proinflammatory changes in circulating cytokines are thought to contribute to obesity-associated morbidity by favoring the onset of insulin resistance and cardiovascular dysfunction (5)(6)(7) . Weight loss induced by caloric restriction or bariatric surgery may limit these alterations (7)(8)(9)(10)(11)(12) , and these effects may contribute to the positive effect of weight loss to reduce obesityassociated morbidity.…”

Section: Introductionmentioning

confidence: 99%

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Gastric bypass–induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers

Barazzoni

Palmisano

Cappellari

et al. 2016

Surgery for Obesity and Related Diseases

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Section: Basalmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Gastric bypass–induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers

Barazzoni

Palmisano

Cappellari

et al. 2016

Surgery for Obesity and Related Diseases

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“…Adipokines, a diverse class of biologically active compounds released by adipose tissue mediate a host of physiological processes including inflammation and glucose and lipid metabolism, play a crucial role in the metabolic effects of obesity and its associated comorbidities [48,49]. However, it is well established that bariatric surgery restores, at least partially, inflammatory adipokine regulation, with studies describing an overall decrease in pro-inflammatory adipokines, such as IL-6 and TNF-α, and an increase in anti-inflammatory adipokines such as adiponectin following RYGB and/or VSG up to one year following the procedure [50][51][52][53][54][55]. Strikingly, there are some discrepancies in the values of C-reactive protein (CRP), a pro-inflammatory adipokine, following bariatric surgery, with both significant increases and decreases results reported [51][52][53][55][56][57].…”

Section: Potential Mechanisms Leading To Weight Loss and Improved Diamentioning

confidence: 99%

Recent advances in the modification of taste and food preferences following bariatric surgery

Primeaux

Silva

Tzeng

et al. 2016

Rev Endocr Metab Disord

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There is a large body of evidence indicating that bariatric surgery provides durable weight loss and health benefits to patients who are obese and have comorbidities such as type 2 diabetes (T2D). However, there are still many questions related to mechanisms of metabolic improvement, predictors of success/failure, and long term consequences, which need to be answered. More recently, there has been a particular interest in the modulation of taste and food preferences that occurs after bariatric surgery and how this affects weight loss in different individuals. Animal models as well as human studies have shed some light on the role of taste in changing food preferences and how these changes may affect weight loss after surgery. The goal of this review is to discuss the physiological and behavioral consequences of bariatric surgery as a treatment for obesity and T2D, with particular emphasis on recent studies describing bariatric surgery-induced modifications in taste perception and food preferences.

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“…On the contrary, systemic and adipose-tissue inflammation seems to decrease following bariatric procedures both at the biochemical and at the clinical level. These changes supposedly promote risk reduction in obesity-associated comorbid conditions including T2DM, cardiovascular diseases, infections, and cancer [20,21,22,23]. …”

Section: Bs and Inflammationmentioning

confidence: 99%

“…Viana et al [20] demonstrated a significant decrease in systemic inflammatory cytokines (IL-6 and TNF-α) 1 year after RYGBP and SG. Sams et al [21] found a significant and rapid increase in subcutaneous adipose anti-inflammatory cytokines (e.g.…”

Section: Bs and Inflammationmentioning

confidence: 99%

Does Gastric Surgery (Such as Bariatric Surgery) Impact the Risk of Intestinal Inflammation?

2016

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Background: The prevalence of morbid obesity and inflammatory bowel disease (IBD) is on the rise in association with a Western lifestyle. Both conditions are characterized by chronic inflammation. Bariatric surgery (BS) is a recommended and widely used approach to address severe obesity and its related comorbidities. Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) are the most frequently performed procedures worldwide. Evidence is scarce on outcomes of BS in IBD patients. Summary: Systemic and adipose-tissue inflammation seems to decrease following BS. Different studies observed decreased serum levels of inflammatory markers (CRP, IL-6, MCP-1, and TNF-α) along with a reduction of insulin resistance both after RYGBP and SG. Several authors documented postbariatric improvement of concomitant chronic inflammatory diseases (rheumatoid arthritis, systemic lupus erythematosus, gout, and psoriasis). There are only few retrospective case series on outcomes of BS in IBD patients. These studies reported safety and feasibility of BS and improvement in IBD status, manifested by prolonged disease remission and decreased use of pharmacotherapy. Weight loss outcomes were excellent and similar to those of non-IBD patients. The preferred surgical approach for morbidly obese IBD patients is SG in order to avoid potential drawbacks of RYGBP, such as malabsorption, intestinal manipulation, and augmentation of technical difficulties for future IBD surgery. Seven cases of newly diagnosed IBD after BS have been reported, which are more likely to result from postoperative intestinal microbial dysbiosis than from directly induced inflammation. Key Messages: This review summarizes the outcomes of BS in IBD patients. SG is the preferable technique for morbidly obese IBD patients, who have potentially a double benefit from BS: weight loss and IBD remission. Further research is necessary to clarify the common pathophysiology of chronic inflammation in morbid obesity and in IBD. Postbariatric changes in gut microbiota should also be assessed to understand whether they promote IBD development or not.

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Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-α. Prospective Clinical Trial

Abstract: RYGB and SG procedures demonstrated a similar impact on adipokine levels in women 1 year post-surgery. Both techniques may improve the course of chronic diseases and the state of inflammation associated with obesity.

Cited by 69 publications

References 46 publications

Gastric bypass–induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers

Gastric bypass–induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers

Recent advances in the modification of taste and food preferences following bariatric surgery

Does Gastric Surgery (Such as Bariatric Surgery) Impact the Risk of Intestinal Inflammation?

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