Gastric bioaccessibility is a conservative measure of nickel bioavailability after oral exposure: Evidence from Ni-contaminated soil, pure Ni substances and Ni alloys

Dutton, Michael D.; Thorn, Ryan James; Lau, W.M.; Vasiluk, Luba; Hale, Beverley

doi:10.1016/j.envpol.2020.115830

Cited by 6 publications

(7 citation statements)

References 33 publications

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“…Both Ni and Cu are also found in the silicate glass and olivine in our slag dusts (Tables S4 and S6 in Supporting Information S1 ). However, recent comparative investigations of Ni bioaccessibility in soils with different Ni solid speciation indicate that the BAF fractions in soils where Ni is predominantly speciated in slag particles and silicates are quite low (0%–15%) due to their low solubility (Dutton et al., 2021 ) and this seems to be similar for our samples.…”

Section: Discussionsupporting

confidence: 77%

“…This was also observed in the dust and soils from the Selebi-Phikwe area (Ekosse et al, 2003(Ekosse et al, , 2004) and soils and waste materials from other similar mining sites such as Sudbury, Canada (Lanteigne et al, 2012), the Kola Peninsula, Russia (Gregurek et al, 1998) and the Zambian Copperbelt (Ettler et al, 2014(Ettler et al, , 2022Vítková et al, 2010). Dutton et al (2021) recently compared the Ni bioaccessibilities in soils with variable Ni mineralogy. They found that, in samples with pentlandite, a primary Ni carrier (79%-80% of the total Ni speciation) in some soils, the BAF values varied in the range of 24.9%-34.6% (Dutton et al, 2021).…”

Section: Contaminant Solid-phase Speciation and Relationship To Bioac...mentioning

confidence: 72%

“…Very high Ni bioaccessibilities (32%–99%) were found in soils spiked with soluble Ni hydroxides and Ni sulfates, however, such species are scarce in mining‐ and smelter‐affected environments (Dutton et al., 2021 ). Studies dealing with Ni smelter polluted soils, where Ni is mainly bound to various oxides phases, indicate much lower BAFs.…”

Section: Discussionmentioning

confidence: 99%

“…Dutton et al (2021) recently compared the Ni bioaccessibilities in soils with variable Ni mineralogy. They found that, in samples with pentlandite, a primary Ni carrier (79%-80% of the total Ni speciation) in some soils, the BAF values varied in the range of 24.9%-34.6% (Dutton et al, 2021). Similar BAFs were also observed for our tailing dusts, where sulfides are the dominant Ni-hosting phases (BAF: 21%-25%).…”

Section: Contaminant Solid-phase Speciation and Relationship To Bioac...mentioning

confidence: 99%

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Contaminant Binding and Bioaccessibility in the Dust From the Ni‐Cu Mining/Smelting District of Selebi‐Phikwe (Botswana)

et al. 2022

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We studied the dust fractions of the smelting slag, mine tailings, and soil from the former Ni‐Cu mining and processing district in Selebi‐Phikwe (eastern Botswana). Multi‐method chemical and mineralogical investigations were combined with oral bioaccessibility testing of the fine dust fractions (<48 and <10 μm) in a simulated gastric fluid to assess the potential risk of the intake of metal(loid)s contaminants. The total concentrations of the major contaminants varied significantly (Cu: 301–9,600 mg/kg, Ni: 850–7,000 mg/kg, Co: 48–791 mg/kg) but were generally higher in the finer dust fractions. The highest bioaccessible concentrations of Co, Cu, and Ni were found in the slag and mine tailing dusts, where these metals were mostly bound in sulfides (pentlandite, pyrrhotite, chalcopyrite). On the contrary, the soil dusts exhibited substantially lower bioaccessible fractions of these metals due to their binding in less soluble spinel‐group oxides. The results indicate that slag dusts are assumed to be risk materials, especially when children are considered as a target group. Still, this exposure scenario seems unrealistic due to (a) the fencing of the former mine area and its inaccessibility to the local community and (b) the low proportion of the fine particles in the granulated slag dump and improbability of their transport by wind. The human health risk related to the incidental ingestion of the soil dust, the most accessible to the local population, seems to be quite limited in the Selebi‐Phikwe area, even when a higher dust ingestion rate (280 mg/d) is considered.

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Section: Discussionsupporting

confidence: 77%

Section: Contaminant Solid-phase Speciation and Relationship To Bioac...mentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Contaminant Solid-phase Speciation and Relationship To Bioac...mentioning

confidence: 99%

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Contaminant Binding and Bioaccessibility in the Dust From the Ni‐Cu Mining/Smelting District of Selebi‐Phikwe (Botswana)

et al. 2022

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“…However, due to man-made reasons or special working conditions, a large amount of Cd ingested by the human body will be harmful to the respiratory tract and reproductive system, as well as to the bones (Kobra et al 2021). Ni is also a trace element, but the body's demand for it is very small and once the body ingests a certain amount of Ni, it can cause inflammation and even affect the body's genetic factors (Michael et al 2021). Cr itself does not have biotoxicity, but the Cr entering the body will be converted into Cr 6+ , which is easily adsorbed on the mucous membrane surface for the respiratory tract and can cause various respiratory inflammatory diseases (Nancy et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Bioaccessibilities and health risk assessment of heavy metals in dust from the Guizhou-Guiyang urban zone, China

郁鑫杰¹,

王济²,

蔡雄飞³

et al. 2021

Preprint

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To investigate the health risks of heavy metals in dust entering the human body from different exposure pathways. In this study, the old urban area of Guiyang was used as the study area to understand the heavy metals concentrations in surface dust, including recreational plazas, main streets, hospitals, residential areas, and schools in this city, and the bioaccessibility in the simulated lung phase and simulated gastrointestinal phase. The results showed that the concentrations of Cu, Pb, Zn, Cd, Ni, and Cr in the dust were higher than the background values, especially the Zn content exceeded the background value by 9.71 times. The bioaccessibility results indicated that the most soluble heavy metals in the simulated lung phase, simulated gastric phase, and simulated intestinal phase were Zn, Ni, and Cu, respectively, and the bioaccessibility of most heavy metals was significantly higher in the gastric phase than in the intestinal phase, and only Cu was higher in the intestinal phase than in the gastric phase. The linear results fit suggested that the total amount of heavy metals alone could not predict the human intake of heavy metals in the dust. Human health risk assessment based on bioaccessibility showed that children had higher non-carcinogenic and carcinogenic risks than adults for both hand-to-mouth ingestion and respiratory inhalation exposure pathways, but none of them exceeded the limit values.

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Nickel uptake in leafy greens from contaminated soil: an investigation into phytoavailability and health risk assessment using in vitro digestion model

Ammara,

Rafiq,

Aziz

et al. 2024

Environ Monit Assess

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Gastric bioaccessibility is a conservative measure of nickel bioavailability after oral exposure: Evidence from Ni-contaminated soil, pure Ni substances and Ni alloys

Cited by 6 publications

References 33 publications

Contaminant Binding and Bioaccessibility in the Dust From the Ni‐Cu Mining/Smelting District of Selebi‐Phikwe (Botswana)

Contaminant Binding and Bioaccessibility in the Dust From the Ni‐Cu Mining/Smelting District of Selebi‐Phikwe (Botswana)

Bioaccessibilities and health risk assessment of heavy metals in dust from the Guizhou-Guiyang urban zone, China

Nickel uptake in leafy greens from contaminated soil: an investigation into phytoavailability and health risk assessment using in vitro digestion model

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