Gastric Artery Embolization Trial for the Lessening of Appetite Nonsurgically (GET LEAN): Six-Month Preliminary Data

Syed, Mubin I.; Morar, Kamal; Shaikh, Azim; Craig, Paul; Khan, Omar; Patel, Sumeet; Khabiri, Hooman

doi:10.1016/j.jvir.2016.07.010

Cited by 54 publications

(62 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A major concern regarding gastric embolization is the risk of gastric mucosal ulceration, erosion, or gastritis. This has been observed in porcine experimental models and in three of the aforementioned pilot studies . However, in all human cases, the course was benign with healing documented on follow‐up gastroscopy.…”

Section: Discussionmentioning

confidence: 54%

“… Weight loss after gastric embolization procedures. Mean weight (±SEM) at baseline and according to follow‐up in all published studies (Kipshidze et al, Bai et al, Syed et al, Weiss et al) reporting on bariatric embolization in human subjects [Color figure can be viewed at http://wileyonlinelibrary.com] …”

Section: Resultsmentioning

confidence: 99%

“…The exact mechanism explaining weight loss remains elusive but a significant and temporary decrease in ghrelin levels has been observed in previous reports . This decrease has however been inconsistent . Ghrelin levels fluctuate throughout the day and according to food intake.…”

Section: Discussionmentioning

confidence: 96%

“…To date, four pilot studies have studied bariatric embolization in human subjects . Taken as whole, none of these studies have reported serious adverse events, other than transient abdominal discomfort, regardless of the size of the particles.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Transradial left gastric artery embolization to treat severe obesity: A pilot study

Pirlet

Ruzsa

Costerousse

et al. 2018

Cathet Cardio Intervent

View full text Add to dashboard Cite

Background Bariatric surgery is currently the only effective treatment with long‐lasting results to treat severe obesity. Objectives We performed a pilot study to evaluate the feasibility, safety and efficacy of percutaneous distal embolization of the left gastric artery (LGA) using a transradial approach. Methods and Results We recruited seven severely obese male patients (mean age 48 ± 7 years) referred for diagnostic coronary angiography. Mean baseline weight was 160 ± 27 kg and body mass index was of 52 ± 8 kg/m2. We successfully injected 300–500 μm polyvinyl alcohol particles using 5Fr catheters and all distal LGA were occluded at the end of procedures. Mean procedure duration was 24 ± 13 min and mean fluoroscopy time was 10 ± 5 min. Six patients reported mild transient epigastric discomfort, which resolved with proton pump inhibitors. At 2 months, the average weight loss was of 7 ± 6 kg (median loss: −10 kg [−2, −11]), 6 ± 12 kg (median loss: −9 kg [−16, +4]) at 6 months and 13 ± 17 kg (median loss: −11 kg [0, −25]) up to 12 months after index procedures. Conclusion Percutaneous transradial LGA embolization appears to be a promising technique to reduce the obesity burden. Randomized trials are required to further delineate the risk/benefit ratio, potential clinical indications and long term results.

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Transradial left gastric artery embolization to treat severe obesity: A pilot study

Pirlet

Ruzsa

Costerousse

et al. 2018

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

“…A minor complication of superficial gastric ulcers that resolved in 30 days occurred in 3 of 4 patients. Mean body weight change at 6 months was 9.2 kg (range, −2.7 to −9.5 kg), which corresponded to a 17% EWL [55]. …”

Section: Bariatric Embolizationmentioning

confidence: 99%

Current and cutting-edge interventions for the treatment of obese patients

Vairavamurthy

Cheskin

Kraitchman

et al. 2017

European Journal of Radiology

View full text Add to dashboard Cite

The number of people classified as obese, defined by the World Health Organization as having a body mass index ≥30, has been rising since the 1980s. Obesity is associated with comorbidities such as hypertension, diabetes mellitus, and nonalcoholic fatty liver disease. The current treatment paradigm emphasizes lifestyle modifications, including diet and exercise; however this approach produces only modest weight loss for many patients. When lifestyle modifications fail, the current “gold standard” therapy for obesity is bariatric surgery, including Roux-en-Y gastric bypass, sleeve gastrectomy, duodenal switch, and placement of an adjustable gastric band. Though effective, bariatric surgery can have severe short- and long-term complications. To fill the major gap in invasiveness between lifestyle modification and surgery, researchers have been developing pharmacotherapies and minimally invasive endoscopic techniques to treat obesity. Recently, interventional radiologists developed a percutaneous transarterial catheter-directed therapy targeting the hormonal function of the stomach. This review describes the current standard obesity treatments (including diet, exercise, and surgery), as well as newer endoscopic bariatric procedures and pharmacotherapies to help patients lose weight. We present data from two ongoing human trials of a new interventional radiology procedure for weight loss, bariatric embolization.

show abstract

Bariatric Embolization: A Possible Non-surgical Option for Weight Reduction

Latif

Weiss

2020

Obesity and Diabetes

View full text Add to dashboard Cite

Gastric Artery Embolization Trial for the Lessening of Appetite Nonsurgically (GET LEAN): Six-Month Preliminary Data

Cited by 54 publications

References 20 publications

Transradial left gastric artery embolization to treat severe obesity: A pilot study

Transradial left gastric artery embolization to treat severe obesity: A pilot study

Current and cutting-edge interventions for the treatment of obese patients

Bariatric Embolization: A Possible Non-surgical Option for Weight Reduction

Contact Info

Product

Resources

About