Gastric and pancreatic response to acid in the duodenum after partial duodenectomy

Way, LW; Grossman, M. I.

doi:10.1152/ajplegacy.1971.220.4.1016

Cited by 11 publications

(2 citation statements)

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“…Protein output to pentagastrin (GF closed) in the present study is about half that reported by Way and G rossman [13], the bicarbonate outputs being closely similar in the two studies. This difference in protein output is almost certainly due to the antral transection performed initially in their dogs with resulting vagal denervation of the pancreas.…”

Section: Discussionsupporting

confidence: 85%

Exocrine Secretory Responses of the Pancreas to Pentagastrin and to a Meat Meal in Dogs

Gupta¹,

Elder²,

Gillespie³

1973

Digestion

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The pancreatic responses of four dogs with pancreatic and gastric fistulae (GF) were studied to intravenous infusion of pentagastrin in doses maximal for gastric acid secretion, and separately to a 400-gramme meat meal. With the GF open a small increase in pancreatic bicarbonate (p < 0.05), and a marked increase in protein output was noted in response to pentagastrin. With the GF closed bicarbonate and protein outputs to pentagastrin (21.5 ± 1.8 SEM/mEq 4 h and 2,305 ± 249 SEM/mg 4 h) were not significantly different from those seen in response to a meat meal (20.6 ± 3.2 SEM/mEq 4 h and 1,884 ± 222 SEM/mg 4 h). These results suggest that when the GF is closed, pentagastrin infusion at doses acid secretion stimulates the pancreas to a degree closely similar to 400-gramme meat meal.

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Section: Discussionsupporting

confidence: 85%

Exocrine Secretory Responses of the Pancreas to Pentagastrin and to a Meat Meal in Dogs

Gupta¹,

Elder²,

Gillespie³

1973

Digestion

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“…They observed an almost identical effect in time, duration, and magnitude and concluded that secretin was the enterogastrone mediating gastric inhibition by intraduodenal acid. Not all studies have agreed with this view and the existence of a secretinindependent inhibitory mechanism in the duodenum has been noted by Way and Grossman (1971) and Konturek, Tasler, and Obtulowicz (1971). In man, Wormsley (1970) has shown that the gastric response to exogenous secretin and to intraduodenal acid differ sufficiently to suggest that secretin may not be the sole mediator of gastric inhibition.…”

Section: Discussionmentioning

confidence: 99%

The role of secretin in the inhibition of gastric secretion by intraduodenal acid

Ward¹,

Bloom²

1974

Gut

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SUMMARY The effect of intraduodenal acid on pentagastrin-stimulated gastric secretion has been investigated in 12 normal subjects and 23 patients with chronic duodenal ulceration. Plasma secretin levels were monitored during each test using a highly sensitive radioimmunoassay.Significant inhibition of gastric secretion occurred in the normal subjects and duodenal ulcer patients. A significant rise in plasma secretin was observed in both groups after intraduodenal acid though there was a complete lack of correlation between the magnitude of the secretin response and the degree of gastric inhibition. Ten subjects received intraduodenal acid and a subsequent intravenous infusion of exogenous secretin (0.125-0.25 units/kg over six minutes). Gastric inhibition occurred after the acid instillation but not after secretin infusion despite plasma secretin levels greatly in excess of those produced by intraduodenal acid.These results suggest that release of secretin by itself cannot explain the gastric inhibitory response to intraduodenal acid in man.The presence of acid in the duodenum is known to inhibit gastric secretion both in animals (Pincus, Friedman, Thomas, and Rehfuss, 1944;Sircus, 1958) and in man (Shay, Gershon-Cohen, and Fels, 1942;Johnston and Duthie, 1964). The mechanism of this response is, however, uncertain. The main possibilities (which may of course interact) appear to be either a vagal reflex or a humoral response particularly involving secretin. The evidence for each of these views is fully discussed elsewhere (Ward, 1974). The role of the vagus has been examined in detail and it appears likely that gastric inhibition is dependent on a vagal reflex in man (Ward, 1974). Strong claims, however, have been made that in dogs secretin is the mediator of gastric inhibition by intraduodenal acid (Johnson and Grossman, 1968) and the present study was therefore undertaken to examine the response with particular emphasis on the role of secretin. Materials and MethodsThe response to intraduodenal acid was investigated in 35 patients, 10 of whom also received an intravenous secretin infusion. There were 12 normal subjects (Orm, 2f) and 23 patients (21m, 2f) with chronic duodenal ulceration. The average age of Received for publication 10 July 1974. the normal subjects was 38 years (range 21-63) and their average weight 71 kg (range 55-83 kg). These subjects were awaiting minor inpatient surgery and all were free of gastrointestinal symptoms. The duodenal ulcer patients were awaiting gastric surgery and in all cases the pathology was confirmed subsequently at laparotomy. Their average age was 42 years (range 27-67) and their average weight 68 kg (range 52-82 kg).A duodenal inhibitory test (Ward, 1973) was carried out on each of the normal subjects and duodenal ulcer patients. The gastric stimulus was an intravenous infusion of pentagastrin at a dose rate of 6 ,g/kg/hr. Gastric samples were collected at 10-minute intervals throughout the test.Once a secretory plateau had been reached 40 ml of 0O1N hydrochloric acid ...

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Antral and duodenal acidification

Wheeler¹,

Prescott²,

Forrest³

1974

The American Journal of Surgery

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Gastric and pancreatic response to acid in the duodenum after partial duodenectomy

Cited by 11 publications

References 0 publications

Exocrine Secretory Responses of the Pancreas to Pentagastrin and to a Meat Meal in Dogs

Exocrine Secretory Responses of the Pancreas to Pentagastrin and to a Meat Meal in Dogs

The role of secretin in the inhibition of gastric secretion by intraduodenal acid

Antral and duodenal acidification

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