Gastric and cardiovascular effects of histamine in the dog

Hirschowitz, Basil I.; Rentz, J; Molina, E; Waldo, Albert L.

doi:10.1007/bf01968106

Cited by 3 publications

(5 citation statements)

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“…The presence of recognition sites for histamine in non-parietal cells in this study correlates with the in vivo regulation by histamine of pepsin [3,25] and somatostatin [I] secretions by the stomach since in both cases, stimulation or inhibition are H, receptor-mediated effects. Finally, our results suggest that muco-peptic and somatostatin secretions by the stomach could be regulated, via CAMP, after cell-surface stimulation of histamine H2 receptors.…”

Section: Discussionsupporting

confidence: 79%

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Histamine interaction on surface recognition sites of H₂‐type in parietal and non‐parietal cells isolated from the guinea pig stomach

Gespach

Bouhours

et al. 1982

FEBS Letters

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In gastric cells isolated by pronase digestion from the guinea pig, histamine stimulated CAMP production in 3 fundic cell fractions (EC50 = 1.6-2 x 10m4 M) enriched in parietal (94%), peptic (63%) and mucous cells (87%) as well as in antral cells (EC5o = 4 x 10e4M) that are devoid of parietal cells. Histamine stimulations were completely inhibited by the H2 antagonist cimetidine (Ki = 0.27-0.57 x 1O-6 M) or by the H1 antagonist diphenhydramine, but at lOO-times lower potency (Ki = 22-45.7 x 10m6 M), indicating the presence of histamine Hz receptors in parietal and nonparietal cells of the guinea pig gastric mucosa. HistamineFundic, antral cell HZ receptor Cyclic AMP Gastric secretion

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Section: Discussionsupporting

confidence: 79%

“…In vivo, histamine regulates endocrine [l] and exocrine secretions of acid and pepsin [2,3] by the stomach. In gastric mucosa, histamine is stored in mast cells as well as in endocrine-like cells [4] and could have an endocrine-paracrine role on these gastric secretions.…”

Section: Introductionmentioning

confidence: 99%

Histamine interaction on surface recognition sites of H₂‐type in parietal and non‐parietal cells isolated from the guinea pig stomach

Gespach

Bouhours

et al. 1982

FEBS Letters

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“…When no attempt was made to control blood pressure, histamine produced a marked vasodepressor response, similar to that observed in several other studies (Hirschowitz et al, 1979;Harvey & Owen, 1984). When autonomic reflexes were removed, the vasodepressor effect was unchanged, confirming that this action of histamine is direct (Harvey & Owen, 1984).…”

Section: Discussionsupporting

confidence: 69%

Positive inotropic effects of histamine in anaesthetized dogs

Einstein

Mihailidou

Richardson

1987

British J Pharmacology

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1 The cardiovascular effects of histamine were examined in dogs anaesthetized with pentobarbitone 2 The effect of histamine on heart rate, blood pressure, left ventricular pressure, dP/dt,,,nv, and dP/dt: IIT (integrated isometric tension) was compared in the presence and absence ofautonomic reflexes and blood pressure control. 3 In innervated animals with no attempt to control blood pressure, histamine produced dosedependent decreases in blood pressure and heart rate and either positive or negative inotropic actions. 4 When autonomic reflexes were abolished, this variability in inotropic response was reduced and histamine produced a slight positive inotropic response. There was a decrease in blood pressure and a positive chronotropic response to histamine. 5 When blood pressure was controlled and the cardiac nerves were intact, histamine produced a decrease in heart rate. However, in the denervated animals, there was a slight increase in heart rate. 6 Inotropic responses to histamine in the blood pressure controlled groups were less variable than when blood pressure was uncontrolled. In all of these animals there was an increase in contractility, the increase being more marked in the denervated group. 7 The H2-receptor agonist impromidine produced a positive inotropic action in intact animals with uncontrolled blood pressure.

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“…However, the data on the role of histamine mechanisms in mediating cholinergic effects on pepsinogen-producing chief cells are ambiguous. Exogenous histamine did not affect pepsinogen secretion in the stomach of awake rats [ 12] and even inhibited this process in dogs [5]. On the other hand, histamine stimulated pepsinogen secretion in isolated mouse [2] or rat [6] stomach and cultured human gastric mucosal cells [7].…”

Section: Resultsmentioning

confidence: 99%

“…Chief cells of the gastric mucosa producing pepsinogen are evolutionary similar to parietal cells [3,10] and functionally depend on their state. However, of mechanisms secretion, nervous and endocrine regulation in these cells differ considerably [5,6,11]. The data on the involvement of main secretagogues in the regulation of pepsinogen production are contradictory due to species specificities and peculiarities of experimental models [9,12].…”

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confidence: 99%

Quantitative analysis of the role of cholinergic, gastrin, and histamine regulatory mechanisms of pepsinogen production in the stomach of narcotized rats

2000

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Pepsinogen secretion in the intraluminally perfused stomach of narcotized rats was induced by electrical stimulation of the vagus nerve or intravenous injection of pentagastrin. Blockade of histamine H 2 receptors inhibited pepsinogen production induced by vagal stimulation by 35%, but caused only a 13% decrease in pentagastrin-stimulated pepsinogen secretion. Key Words: pepsinogen; vagus; pentagastrin; histaminePractically in all mammals, vagal cholinergic and gastrin effects on parietal cells of the stomach are mediated by histamine-producing cells [4]. Chief cells of the gastric mucosa producing pepsinogen are evolutionary similar to parietal cells [3,10] and functionally depend on their state. However, of mechanisms secretion, nervous and endocrine regulation in these cells differ considerably [5,6,11]. The data on the involvement of main secretagogues in the regulation of pepsinogen production are contradictory due to species specificities and peculiarities of experimental models [9,12]. The role of histamine in mediating vagal and gastrin effects on chief cells of the stomach remains unclear. Here we evaluated the role of cholinergic, gastrin, and histamine mechanisms in the regulation of pepsinogen secretion in the stomach of narcotized rats. MATERIALS AND METHODSExperiments were performed on 42 male SpragueDawley rats weighing 309• g and kept at 20+1~ under a 12-h light/dark schedule and ad libitum food supply (Rappolovo R50258-92). One day before operation, the animals were deprived of food, but had free access to water.The rats were narcotized with intraperitoneal injection of choral hydrate and urethane (800+ 100 mg/kg, Sigma). Isotonic NaC1 containing 3 mM NaHCO 3 and 2% glucose was administered intravenously (1 ml/h) to prevent acidosis and dehydration. The animals were heated on a temperature-controlled table with incandescent lamp. Heart rate (HR), blood pressure (BP), and rectal temperature were measured.After tracheotomy, catheterization of the right femoral artery and vein, and median laparotomy were carried out subdiaphragmatic vagotomy, gastric sympathectomy, and ligation of the left adrenal gland were conducted if required. The stomach was perfused with isotonic NaC1 at a flow rate of 0.7 ml/min, 37~ pH 6.0, and 0 mm Hg. The solution was administered through a catheter and removed via a perforated polyethylene tube introduced through a duodenal section into the pylorus. The peripheral end of the left subdiaphragmatic vagus nerve was demyelinated and stimulated with rectangular pulses (6 V, 1 msec, 8 Hz) delivered through silver electrodes for 10 min.Perfusate samples were taken at 15-min intervals using a fraction collector (LKB). Pepsinogen concen-0007-4888/00/0001-7525.00 9Kluwer Academic/Plenum Publishers

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Gastric and cardiovascular effects of histamine in the dog

Cited by 3 publications

References 24 publications

Histamine interaction on surface recognition sites of H₂‐type in parietal and non‐parietal cells isolated from the guinea pig stomach

Histamine interaction on surface recognition sites of H₂‐type in parietal and non‐parietal cells isolated from the guinea pig stomach

Positive inotropic effects of histamine in anaesthetized dogs

Quantitative analysis of the role of cholinergic, gastrin, and histamine regulatory mechanisms of pepsinogen production in the stomach of narcotized rats

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Gastric and cardiovascular effects of histamine in the dog

Cited by 3 publications

References 24 publications

Histamine interaction on surface recognition sites of H2‐type in parietal and non‐parietal cells isolated from the guinea pig stomach

Histamine interaction on surface recognition sites of H2‐type in parietal and non‐parietal cells isolated from the guinea pig stomach

Positive inotropic effects of histamine in anaesthetized dogs

Quantitative analysis of the role of cholinergic, gastrin, and histamine regulatory mechanisms of pepsinogen production in the stomach of narcotized rats

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Histamine interaction on surface recognition sites of H₂‐type in parietal and non‐parietal cells isolated from the guinea pig stomach

Histamine interaction on surface recognition sites of H₂‐type in parietal and non‐parietal cells isolated from the guinea pig stomach