Gastric Adenoma with Low-Grade Dysplasia: Two Countries, Two Outcomes

Lee, Sun‐Young

doi:10.1007/s10620-013-2860-1

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…In turn, this resulted in considerable selection bias in our analysis. Second, the pathological diagnoses of EGC varied not only between east and west but also between eastern countries, which might resulted in baseline bias . Third, the eligible studies were all from Asia , especially from Korea , where the incidence of gastric cancer and the detection rate of EGC are high.…”

Section: Discussionmentioning

confidence: 99%

“…Second, the pathological diagnoses of EGC varied not only between east and west but also between eastern countries, which might resulted in baseline bias. 34 Third, the eligible studies were all from Asia, especially from Korea, where the incidence of gastric cancer and the detection rate of EGC are high. Thus, the situation of Western countries remains unclear, and our results need to be validated with data from several other regions.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic resection versus surgery for early gastric cancer: a systematic review and meta‐analysis

Sun

Chen

et al. 2016

Digestive Endoscopy

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Objectives: Endoscopic resection (ER) is becoming an increasingly used treatment option for early gastric cancer (EGC); however, data comparing the long-term outcomes of ER and surgery are limited. Accordingly, we here aimed to perform a meta-analysis to clarify the long-term outcomes and safety of ER and surgery for EGC.Methods: Literature on the direct comparison of ER and surgery for EGC was retrieved from the Medline, PubMed and Scopus databases. We selected the eligible studies, extracted data, and assessed the quality scores according to the guidelines. The overall survival (OS), recurrence-free survival (RFS), and adverse event rates were investigated, and the pooled hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI) were estimated.Results: Nine retrospective studies were identified, including 973 and 1190 participants undergoing ER and surgery, respectively. There were no significant differences regarding the OS (HR: 0.995, 95% CI: 0.836-1.185; P = 0.959) and adverse event rates (OR: 0.50, 95% CI: 0.20-1.28, P = 0.148) between ER and gastrectomy. However, patients undergoing ER had significantly shorter RFS (HR: 7.226, 95% CI: 1.718-30.400, P = 0.007) than those undergoing gastrectomy.Conclusions: Despite the limitations of this review, including the retrospective nature of all included studies, our results suggest that ER might be a feasible and safe treatment strategy compared to that of gastrectomy for EGC; however, careful endoscopic surveillance is needed for ensuring favorable outcomes. These findings should be confirmed in further large-scale, prospective, randomized, controlled trials from different countries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endoscopic resection versus surgery for early gastric cancer: a systematic review and meta‐analysis

Sun

Chen

et al. 2016

Digestive Endoscopy

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“…Regarding the treatment of adenoma, particularly with low-grade dysplasia (LGD), there is controversy over whether to treat all LGD or selectively treat LGD with risk factors. Since the diagnosis of gastric adenoma with LGD in Korea carries a substantial risk of developing cancer, 4 gastric adenomas with either LGD or high-grade dysplasia (HGD) are usually resected endoscopically. However, no treatment strategy has been established for mixed lesions with gastric cancer and adenoma, since gastric cancer derived from the adenoma-carcinoma sequence is less frequent.…”

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confidence: 99%