Gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation

Hwang, Seong Wook; Lee, Sun Jae; Park, Po Eun; Kim, Mee Seon; Bae, Han Ik

doi:10.1111/j.1755-9294.2011.01118.x

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…The results of disease-free survival of GAHED in the present study support the previous descriptions. Motoyama et al and Hwang et al reported a case of gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation [6,16]. They suggest that choriocarcinoma or hepatoid carcinoma may show the retrodifferentiation related to the unfavourable pathological differentiation [16].…”

Section: Discussionmentioning

confidence: 99%

“…Motoyama et al and Hwang et al reported a case of gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation [6,16]. They suggest that choriocarcinoma or hepatoid carcinoma may show the retrodifferentiation related to the unfavourable pathological differentiation [16]. Gastric neuroendocrine carcinoma also has a propensity to behave in an aggressive clinical fashion [17].…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathologic study of 10 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation

Yorita¹

2018

pjp

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Gastric adenocarcinoma with hepatoid or enteroblastic differentiation (GAHED), known also as AFP-producing carcinoma, is a rare neoplasm. Ten cases with GA-HED and 209 cases without GAHED were selected. Clinicopathological features of GAHED were investigated. The disease-free survival (DFS) of the GAHED group was compared with that of the non-GAHED group. Grossly, the tumours consisted of two early types and eight advanced types. Histologically, all tumours were composed of various proportions of tubular, cribriform, papillary, solid, and/or trabecular growth patterns of clear to slightly eosinophilic tumour cells. Hyaline globules were observed in all tumours. AFP and Hep-Par1 were immunoreactive in all tumours. In fluorescence in situ hybridisation of HER2 gene/chromosome 17, the amplification of HER2 gene was observed in two cases that showed positive reaction for HER2 protein. Clinical follow-up was available in nine cases. Regarding the clinical outcome, 3 and 6 patients were alive without disease and alive with disease, respectively. In a statistical analysis, the DFS of the GAHED group was significantly worse than that of the non-GAHED group. GAHED is morphologically characterised by various growth patterns of clear to slightly eosinophilic tumour cells and intracytoplasmic possession of hyaline globules. This tumour may have the potential to behave in an aggressive clinical fashion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinicopathologic study of 10 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation

Yorita¹

2018

pjp

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“…Other germ cell tumor elements may present alongside embryonal carcinoma, yolk sac tumors, and hepatoid adenocarcinoma [ 58 59 ]. Only a few cases involving pure gastric yolk sac tumors have been documented [ 60 61 62 63 ].…”

Section: Choriocarcinomamentioning

confidence: 99%

Unusual or Uncommon Histology of Gastric Cancer

Shin,

Park

2024

J Gastric Cancer

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This review comprehensively examines the diverse spectrum of gastric cancers, focusing on unusual or uncommon histology that presents significant diagnostic and therapeutic challenges. While the predominant form, tubular adenocarcinoma, is well-characterized, this review focuses on lesser-known variants, including papillary adenocarcinoma, micropapillary carcinoma, adenosquamous carcinoma, squamous cell carcinoma (SCC), hepatoid adenocarcinoma, gastric choriocarcinoma, gastric carcinoma with lymphoid stroma, carcinosarcoma, gastroblastoma, parietal cell carcinoma, oncocytic adenocarcinoma, Paneth cell carcinoma, gastric adenocarcinoma of the fundic gland type, undifferentiated carcinoma, and extremely well-differentiated adenocarcinoma. Although these diseases have different nomenclatures characterized by distinct histopathological features, these phenotypes often overlap, making it difficult to draw clear boundaries. Furthermore, the number of cases was limited, and the unique histopathological nature and potential pathogenic mechanisms were not well defined. This review highlights the importance of understanding these rare variants for accurate diagnosis, effective treatment planning, and improving patient outcomes. This review emphasizes the need for ongoing research and case studies to enhance our knowledge of these uncommon forms of gastric cancer, which will ultimately contribute to more effective treatments and better prognostic assessments. This review aimed to broaden the pathological narrative by acknowledging and addressing the intricacies of all cancer types, regardless of their rarity, to advance patient care and improve prognosis.

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Gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation

Cited by 2 publications

References 15 publications

Clinicopathologic study of 10 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation

Clinicopathologic study of 10 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation

Unusual or Uncommon Histology of Gastric Cancer

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