Gastric Adenocarcinoma Presenting as Generalized Cutaneous Metastases

Nicolás-Sánchez, F.J.; Garreta-Messegue, J.; Fernández-Cabrera, L.; Sarrat-Nuevo, Rosa María; Nicolás-Sánchez, M.E.; Cabau-Rubies, J.

doi:10.1016/s1578-2190(07)70433-x

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…The most common skin metastasis is adenocarcinoma (60%), followed by squamous cell carcinoma (15%). Six percent of skin metastases secondary to parenchymal visceral tumors are caused by gastrointestinal tumors [ 5 ]. Skin metastasis affects 0.7–9% of all cancer patients [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report

Zheng

Huang

et al. 2021

Open Life Sciences

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Background Duodenal adenocarcinoma (DA) with skin metastasis as initial manifestation is clinically rare. In this study, we report a rare case of skin metastasis of DA. Case presentation An 84-year-old male patient developed multiple ecchymoses on the trunk and lower extremities. Physical examination showed that the ecchymosis was dark red and had a hard texture, but showed no bulging, rupture, or tenderness. The skin biopsy implied skin metastatic adenocarcinoma. After an endoscopic duodenal biopsy, the patient was finally diagnosed with DA with skin metastasis. The patient received two courses of oral treatment of Tegafur (40 mg, bid d1–d14). However, the patient stopped taking Tegafur because of its poor effect and received Chinese medicine as a replacement treatment. Unfortunately, he was lost to follow-up. Conclusions Early diagnosis of DA metastasis is of significant importance as prognosis of these patients is poor.

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Section: Discussionmentioning

confidence: 99%

Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report

Zheng

Huang

et al. 2021

Open Life Sciences

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“…Cutaneous metastases are most commonly adenocarcinomas (60 %), but 15 % are squamous cell carcinomas. Only 6 % of cutaneous metastases that are secondary to solid visceral tumors are caused by gastrointestinal carcinomas [2,3]. Signet ring cell carcinoma of the duodenum is extremely uncommon [4].…”

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Primary gastric, duodenal, and rectal signet ring cell carcinoma revealed by cutaneous metastasis

Ismaili¹,

Dekhay²,

Moussaoui³

et al. 2011

Endoscopy

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We report a particularly interesting case of cutaneous metastases, which revealed three sites of signet ring cell carcinoma. A 50-year-old woman presented with painless cutaneous nodules, along with a change in bowel habit and weight loss. She had no history of rectal bleeding. Skin examination revealed multiple nodules on the left side of her neck (• " Fig. 1 a), below her right breast, on her back in a zoster-like distribution, and in the perineal region (• " Fig. 1 b). The nodules, which were erythematous and not well-circumscribed, were soft, slightly indurated, and non-mobile. Histopathological examination of the skin nodules revealed diffuse infiltration of the dermis and subcutaneous tissue by tumor cells. Immunohistochemical analysis indicated a diagnosis of secondary tumor and was suggestive of digestive tract origin. Colonoscopy revealed a congested, elevated rectal mass, between 5 cm and 8 cm from the anal verge, which was causing partial narrowing of the lumen (• " Fig. 2). Histological examination revealed a signet ring cell adenocarcinoma (• " Fig. 3). In view of the histological finding of rectal signet ring cell adenocarcinoma, gastroscopy was performed to exclude a primary gastric tumor. This revealed multiple nodules over the body of the stomach, and within the second part of the duodenum. Histological examination of gastric and duodenal biopsies was compatible with a signet ring cell carcinoma. The patient died 2 weeks later. Cutaneous metastasis is a relatively uncommon manifestation of visceral malignancies. It mostly occurs late in the course of the disease, but may also be the first presentation of an underlying cancer [1]. Cutaneous metastases are most commonly adenocarcinomas (60 %), but 15 % are squamous cell carcinomas. Only 6 % of cutaneous metastases that are secondary to solid visceral tumors are caused by gastrointestinal carcinomas [2,3]. Signet ring cell carcinoma of the duodenum is extremely uncommon [4]. Our case therefore showed both unusual clinical and Primary gastric, duodenal, and rectal signet ring cell carcinoma revealed by cutaneous metastasis UCTN -Unusual cases and technical notes E209Ismaili Z et al. Primary gastric, duodenal, and rectal signet ring cell carcinoma revealed by cutaneous metastasis … Endoscopy 2011; 43: E209 -E210

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Carcinoma gástrico con metástasis en la piel

González-Paredes

2008

Piel

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Gastric Adenocarcinoma Presenting as Generalized Cutaneous Metastases

Cited by 3 publications

References 9 publications

Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report

Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report

Primary gastric, duodenal, and rectal signet ring cell carcinoma revealed by cutaneous metastasis

Carcinoma gástrico con metástasis en la piel

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