Gastric Acidity and Gastric Biopsy in Thyrotoxicosis

Böck, O.; Witts, L. J.

doi:10.1136/bmj.2.5348.20

Cited by 29 publications

(11 citation statements)

References 5 publications

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“…Our findings differ strikingly from those reported by Bock and Witts (1963), and this result is almost certainly due to a difference in the type of patients studied. If only the larger number of females are considered the mean duration of symptoms was similar for the two groups, but the age distribution of the cases was quite different.…”

Section: Discussioncontrasting

confidence: 99%

“…Basal acid and pepsin secretions have also been estimated and gastric biopsies were taken in a number of the patients. Our findings differ in several respects from those of Bock and Witts (1963). * Lecturer in Therapeutics, University of Aberdeen.…”

contrasting

confidence: 99%

“…The true incidence of achlorhydria in hyperthyroidism cannot therefore be assessed from-these previous observations, and, using the augmented histamine test (Kay, 1953), Card and Sircus (1958) stated that no alteration in gastric secretion was found in hyperthyroid patients, but no details were given. More recently Bock and Witts (1963) reported a detailed study of gastric secretion in hyperthyroidism and reached similar conclusions. They initially performed the azuresin (" diagnex ") test on 18 patients and then carried out more detailed studies with the augmented histamine test in a further 29.…”

supporting

confidence: 61%

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Gastric Secretion in Hyperthyroidism

Williams¹,

Blair²

1964

BMJ

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Section: Discussioncontrasting

confidence: 99%

contrasting

confidence: 99%

supporting

confidence: 61%

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Gastric Secretion in Hyperthyroidism

Williams¹,

Blair²

1964

BMJ

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“…Other disorders of water and electrolyte metabolism and of endocrine function develop with cirrhosis. Gastric hyposecretion without histological change in the gastric mucosa has been reported with adrenal, pituitary, and thyroid gland disorders (Smith, Delamore, and Williams, 1961;Bock and Witts, 1963), as well as in undernutrition (Webster and Armour, 1934). Adrenal insufficiency and undernutrition appear irrelevant to gastric secretion in cirrhosis (Ostrow et al, 1960;Bendett et al, 1963), and primary nutritional or endocrine disease was not identified in our patients; thus, possible metabolic relationships with gastric secretion in cirrhosis remain obscure.…”

Section: Gastric Secretory Response To Peptone Stimulusmentioning

confidence: 54%

Reduced gastric acid output in cirrhosis: Quantitation and relationships

Scobie¹,

Summerskill²

1964

Gut

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EDITORIAL SYNOPSIS Basal and maximal (post-histamine) acid outputs were significantly reduced in patients with cirrhosis. A subnormal secretory response to stimulation with peptone was also found. Gastric hyposecretion was not related to the aetiology or severity of the hepatic disease nor to the extent or presence of a portal-collateral circulation. Increased gastric production of ammonia in cirrhosis did not affect acid output significantly, and the reduced response to histamine was not due to increased serum histaminase activity. Since a significant relationship was demonstrated between hypokalaemia and hyposecretion, and since the output of gastric juice appeared more greatly reduced in volume than acid concentrations, the possibility of a relationship between gastric hyposecretion and disorders of water and electrolyte metabolism is considered.

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“…In addition, apart from these anaemic states, other patients may show recovery in acid secretion, for example, after treatment in thyrotoxicosis (Bock and Witts, 1963) and tropical sprue (Vaish, Sampathkumar, Jacob, and Baker, 1965) and also the apparently normal patient (Weir, 1967). Thus it is possible that many factors are involved in any one case.…”

mentioning

confidence: 99%